Publications by authors named "Zhengbang Dong"
Plaque psoriasis with renal dysfunction successfully treated with ixekizumab.
Hemodial Int
January 2025
Psoriasis is an immune-mediated chronic inflammatory skin disease and chronic kidney disease is one of the common comorbidities of psoriasis. Ixekizumab, a humanized IgG4 monoclonal antibody, has been approved for the treatment of moderate-to-severe plaque psoriasis in recent years. However, ixekizumab has not been studied in a population of patients with renal insufficiency.
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- The study investigates the role of nuclear characteristics and the tumor microenvironment (TME) in differentiating basal cell carcinoma (BCC) from trichoepithelioma (TE) and categorizing BCC into high-risk (HR) and low-risk (LR) types.
- An automated deep learning workflow was developed, training on 161 H&E-stained tissue sections, achieving high performance in tumor region identification and risk stratification; the MSA-U-Net model showed precision of 0.910 and the differentiation classifier had AUC values of around 0.977 across datasets.
- Key features distinguishing BCC from TE included various nuclear and TME metrics such as homogeneity and elongation
Importance: Growing research suggests that the prevalence of cutaneous immune-related adverse events (cirAEs) is associated with favorable outcomes among individuals with cancer who receive immune checkpoint inhibitor (ICI) treatment.
Objective: To identify whether the presence of cirAEs and their subtypes subsequent to ICI administration is associated with enhanced cancer prognosis.
Data Sources: The PubMed, Embase, Cochrane Library, and Web of Science databases were searched for publications examining the association between cirAE development during ICI treatment and subsequent cancer prognosis.
Efficacy of adalimumab in pediatric generalized pustular psoriasis: case series and literature review.
J Dermatolog Treat
September 2022
Article Synopsis
- Generalized pustular psoriasis (GPP) is a serious form of psoriasis in children that often requires slow-acting treatments with unpredictable side effects, such as acitretin and methotrexate.
- Recent evidence suggests that adalimumab, an anti-TNF-α therapy, is effective in adults but lacks established research for pediatric use.
- A study showed that seven children treated with adalimumab experienced rapid improvement in skin lesions, indicating it could be a promising alternative for those unresponsive to traditional therapies.
(a) To evaluate the efficacy and safety of narrow-band intense-pulsed light (DPL) in immediate post-operative scar. (b) To observe the process of scar formation under dermoscopy in the first 6 months. Nine patients with postoperative scars were enrolled in the randomized, prospective, split-scar study.
View Article and Find Full Text PDFThe present study aimed to investigate the role of janus kinase (JAK)1/STAT1 in interferon (IFN)‑γ‑induced apoptosis in human melanocytes. Following IFN‑γ treatment, the viability of human melanocytes were analyzed using a Cell Counting Kit‑8 assay and the apoptotic rate was determined using flow cytometry. Western blotting was also performed to analyze the phosphorylation levels of JAK1, JAK2 and the transcriptional factor STAT1, as well as the expression levels of Bcl‑2, Bax, Bcl‑2 homologous antagonist killer (Bak) and cleaved caspase‑3.
View Article and Find Full Text PDFWorldwide, metastatic melanoma of the skin has an aggressive course with high morbidity and mortality. Therefore, an increased understanding of the pathogenesis of metastatic melanoma has gained increasing attention, including the role of epigenetic modification and competing endogenous RNA (ceRNA). This study aimed to used bioinformatics data to undertake an integrative analysis of long noncoding RNA (lncRNA), microRNA (miRNA) and mRNA expression to construct a ceRNA network in metastatic melanoma.
View Article and Find Full Text PDFOncogenomic analysis identifies novel biomarkers for tumor stage mycosis fungoides.
Medicine (Baltimore)
May 2018
Patients with mycosis fungoides (MF) developing tumors or extracutaneous lesions usually have a poor prognosis with no cure has so far been available. To identify potential novel biomarkers for MF at the tumor stage, a genomic mapping of 41 cutaneous lymphoma biopsies was used to explore for significant genes.The gene expression profiling datasets of MF were obtained from Gene Expression Omnibus database (GEO).
View Article and Find Full Text PDFCutaneous phaeohyphomycosis caused by Exophiala dermatitidis: A case report and literature review.
Indian J Dermatol Venereol Leprol
December 2016
We report a case of cutaneous phaeohyphomycosis caused by Exophiala dermatitidis. An adult male presented with a 1 month history of erythematous swelling and ulcer on the right forearm. E.
View Article and Find Full Text PDFBackground: Metastasis to penis usually arises from genitourinary organs, but in rare cases, metastasis comes from the sigmoid colon. Furthermore, very few cases of penile metastasis of primary sigmoid colon carcinoma have been reported.
Case Presentation: We described a case of a 53-year-old man with penile metastasis of sigmoid colon carcinoma along with a review of the literature.