Publications by authors named "ZhengYu Lin"
Background & Aims: Current prognostic models for patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) are not extensively validated and widely accepted. We aimed to develop and validate a continuous model incorporating tumor burden and biology for individual survival prediction and risk stratification.
Methods: Overall, 4,377 treatment-naive candidates for whom TACE was recommended, from 39 centers in five countries, were enrolled and divided into training, internal validation, and two external validation datasets.
Article Synopsis
- Remote programming for implantable pulse generators allows online adjustments for Parkinson patients post-DBS surgery, but patient attitudes and needs regarding this method remain unclear.
- A web-based survey was conducted with 463 Parkinson patients, revealing that many faced logistical burdens with standard programming but a significant portion favored remote programming despite some challenges.
- Results showed that 62% of those who tried remote programming preferred it, highlighting the need for clinicians to address issues such as prescription access and insurance coverage to fully benefit from this technology.*
Objective: Intraventricular baclofen has been reported as an alternative to intrathecal baclofen for managing refractory spasticity and dystonia in some circumstances. In this report, we described a frame-based stereotactic approach for precisely positioning of the infusion catheter into the third ventricle.
Material And Methods: High resolution contrast-enhanced anatomical MR sequences was acquired prior to surgery for pre-planning.
People with Parkinson's disease (PwPD) who undergo deep brain stimulation (DBS) surgery could benefit from remote programming (RP), which has proven to be both effective and economical. However, there is limited research on PwPD with DBS implants who have completed all programming sessions exclusively through remote means (full remote programming, FRP). This case report documents the experiences of five PwPD who underwent FRP, with four demonstrating improvements in motor symptoms, quality of life, and medication reduction.
View Article and Find Full Text PDFObjectives: This study aimed to evaluate the accuracy of percutaneous computed tomography (CT)-guided puncture based on machine vision and augmented reality in a phantom.
Materials And Methods: The surgical space coordinate system was established, and accurate registration was ensured using the hierarchical optimization framework. Machine vision tracking and augmented reality display technologies were used for puncture navigation.
Article Synopsis
- * Traditional treatments like chemotherapy and radiotherapy offer limited benefits for these patients, prompting the exploration of alternatives such as iodine-125 seed interstitial brachytherapy.
- * In 2023, the Chinese College of Interventionalists convened experts to create standardized guidelines for this treatment, covering everything from suitability and preparation to potential complications and follow-up care.
Article Synopsis
- This expert consensus outlines guidelines for diagnosing and treating lung cancer that appears as multiple ground glass nodules.
- Key topics include strategies for monitoring patients, how to differentiate between types of nodules, methods for accurate diagnosis and staging, treatment options, and follow-up care after treatment.
- The review emphasizes the importance of informed clinical practices based on the latest literature.
Image- and video-based 3D human recovery (i.e., pose and shape estimation) have achieved substantial progress.
View Article and Find Full Text PDFBackground And Purpose: The aim was to demonstrate the feasibility, reliability and validity of an in-home remote levodopa challenge test (LCT), as delivered through an online platform, for patients with Parkinson's disease (PwPD).
Methods: Patients with Parkinson's disease eligible for deep brain stimulation surgery screening were enrolled. Participants sequentially received an in-home remote LCT and an in-hospital standard LCT (separated by 2.
The characterization of neural signatures within the somatosensory pathway is essential for elucidating the pathogenic mechanisms of central post-stroke pain (CPSP) and developing more effective treatments such as deep brain stimulation (DBS). We explored the characteristics of thalamic neural oscillations in response to varying pain levels under multi-day local field potential (LFP) recordings and examined the influences of continuous DBS on these thalamic activities. We recorded LFPs from the left ventral posterolateral thalamus (VPL) of a patient with CPSP in the resting state under both off- and on-stimulation conditions.
View Article and Find Full Text PDFBackground: Remote programming (RP) is an emerging technology that enables the adjustment of implantable pulse generators (IPGs) via the Internet for people with Parkinson's disease (PwPD) who have undergone deep brain stimulation (DBS). Previous studies have not comprehensively explored the effectiveness of RP in managing motor symptoms, often omitting assessments such as the rigidity and retropulsion tests during the follow-up. This study evaluates the comprehensive improvements in motor performance and the potential cost benefits of RP for PwPD with DBS.
View Article and Find Full Text PDFArticle Synopsis
- Deep brain stimulation (DBS) can help manage severe tardive dystonia (TD) symptoms, even in patients with major psychiatric disorders, who typically don't qualify for DBS.
- A study of six TD patients who underwent bilateral anterior capsulotomy with STN-DBS showed significant improvements in dystonia, disability, depression, anxiety, and overall quality of life over 1-3 years post-treatment.
- The research indicated a high percentage of symptom reduction and no serious side effects, suggesting this combination therapy is both effective and safe for severe TD patients.
Background: Patients suffering from refractory obsessive-compulsive disorder (OCD) who have undergone deep brain stimulation (DBS) surgery require repeated in-person programming visits. These sessions could be labor-intensive and may not always be feasible, particularly when in-person hospital visits are restricted. Telemedicine is emerging as a potential supplementary tool for post-operative care.
View Article and Find Full Text PDFBackground And Objectives: The thalamic ventral intermediate nucleus (VIM) is a well-established target for deep brain stimulation (DBS) in the treatment of essential tremor (ET). Increasing data indicate that the posterior subthalamic area (PSA) may be superior, but high-level evidence is limited. We aimed at further comparing the intraindividual efficacy and side effect profile of PSA vs VIM DBS in ET.
View Article and Find Full Text PDFBackground: Subthalamic nucleus (STN) and globus pallidus interna (GPi) are two main structures primarily targeted by deep brain stimulation (DBS) to treat advanced Parkinson's disease (PD). A subset of cases with unsatisfactory outcomes may benefit from rescue DBS surgery targeting another structure, while these patients' characteristics have not been well described and this phenomenon has not been well reviewed.
Methods: This monocentric retrospective study included patients with PD, who underwent rescue STN DBS following an unsatisfactory outcome of the initial bilateral GPi DBS in a retrospective manner.
Article Synopsis
- The article in question addresses an academic topic and has been published with a specific Digital Object Identifier (DOI).
- The DOI provides a permanent link to the document for easy access and citation.
- The note indicates that there is a correction to the original article, which is important for accuracy in research and scholarship.
Anterior Capsulotomy for Refractory Obsessive-Compulsive Disorder: A Tractography and Lesion Geometry study.
Stereotact Funct Neurosurg
December 2023
Introduction: A bilateral anterior capsulotomy effectively treats refractory obsessive-compulsive disorder (OCD). We investigated the geometry of lesions and disruption of white matter pathways within the anterior limb of the internal capsule (ALIC) in patients with different outcomes.
Methods: In this retrospective study, we analyzed data from 18 patients with refractory OCD who underwent capsulotomies.
Five new eudensamane-type sesquiterpene lactones, clasamanes A-E (-), three new dolabellane-type diterpenes, clabellanes A-C (-), and fifteen known compounds (-) were isolated from the ethanolic extract of Taiwanese soft coral spp. The structures of all undescribed components (-) were determined by analysis of IR, mass, NMR, and UV spectroscopic data. The absolute configuration of new compounds was determined by using circular dichroism and DP4+ calculations.
View Article and Find Full Text PDFObjectives: To investigate the value of quantitative parameters derived from gadobenate dimeglumine-enhanced magnetic resonance imaging (MRI) for predicting molecular subtype of hepatocellular carcinoma (HCC) and overall survival.
Methods: This multicenter retrospective study included 218 solitary HCC patients who underwent gadobenate dimeglumine-enhanced MRI. All HCC lesions were resected and pathologically confirmed.
Objective: This study aimed to examine the effectiveness and safety of respiratory sensing methods in nonvascular interventional therapy of liver tumors.
Materials And Methods: In this study, 64 patients with primary liver cancer or liver metastasis were retrospectively analyzed. According to two widely used clinical techniques to limit respiratory movement-breath holding and respiratory sensing technology-they were randomly allocated into two groups: respiratory gated and respiratory training.
Introduction: Microwave ablation (MWA) is an effective and safe approach for the treatment of ground-glass nodule (GGN)-like lung cancer, but long-term follow-up is warranted. Therefore, this multi-center retrospective study aimed to evaluate the results of MWA for the treatment of peripheral GGN-like lung cancer with a long-term follow-up.
Materials And Methods: From June 2013 to January 2018, a total of 87 patients (47 males and 40 females, mean age 64.
Article Synopsis
- Ménière's disease (MD) is linked to fluid build-up in the inner ear, but mass spectrometry-based proteomics has not previously been used to study it.
- Researchers analyzed protein expression in blood samples from 15 MD patients and 15 healthy people, finding significant differences that point to potential biomarkers for the disease.
- The study suggests that endocytosis plays a role in MD's development, with CHMP1A and MMP9 identified as possible biomarkers for diagnosis and understanding the disease's mechanisms.