Synopsis of recent research by authors named "ZhengSheng Wu"
- Zhengsheng Wu's recent research primarily focuses on the mechanisms of drug resistance and metastasis in breast cancer, utilizing novel three-dimensional culture models and exploring the roles of long non-coding RNAs and alternative splicing in these processes.
- His studies have developed a vascularized micro-tumor model to improve high-throughput drug screening efficiency, and he has identified critical molecular feedback loops, such as the LINC00460-FUS-MYC axis, that enhance drug resistance and metastatic behavior in breast cancer cells.
- Wu's work also encompasses therapeutic applications and the implications of exosome-mediated interactions in tumor microenvironments, as seen in studies on hepatocellular carcinoma and diffuse large B-cell lymphoma, demonstrating an integrative approach to understanding and targeting cancer progression.
