Lipid metabolic profiling and diagnostic model development for hyperlipidemic acute pancreatitis.

Introduction: Hyperlipidemic acute pancreatitis (HLAP) is a form of pancreatitis induced by hyperlipidemia, posing significant diagnostic challenges due to its complex lipid metabolism disturbances.

Methods: This study compared the serum lipid profiles of HLAP patients with those of a healthy cohort using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Orthogonal partial least squares discriminant analysis (OPLS-DA) was applied to identify distinct lipid metabolites.

The relationship between coffee-related factors and cortical and hippocampal structure: a triangulation of evidence approach and Mendelian randomization research.

Objective: Existing studies have reported sustained changes in the cortical structure of rats due to coffee-related factors, which are speculated to occur in the human body. However, there is a lack of research on this topic. Additionally, previous observational studies have found the impact of diseases on cortical structure and the potential therapeutic effects of coffee on these diseases.

Light at night exposure and risk of breast cancer: a meta-analysis of observational studies.

Objective: The aim of this meta-analysis is to evaluate the impact of light at night (LAN) exposure on the risk of breast cancer across varying factors.

Method: We conducted a systematic search of literature up to July 15, 2023, including PubMed, Cochrane Library, and Embase databases, using keywords related to breast cancer and LAN exposure. Cohort study and case-control study literature on night light exposure and breast cancer risk were included.

Improvement of Mechanical Properties of Composites with Surface Modified BC for Precision Machining.

In order to solve the problem of difficult sintering and high brittleness of BC-based ceramics, BC@ZrB-TiB composite powder was synthesized by molten salt method, and BC-(Zr, Ti)B composite ceramics were successfully prepared by spark plasma sintering. The effects of different raw material ratios on the composition, microstructure, and mechanical properties of the prepared composite ceramics were characterized by XRD, XPS, SEM, and TEM. The results show that ZrB and TiB were grown on the surface of BC by template mechanism to form a dense nanocrystalline coating, and the original surface of BC was exposed gradually with the decrease of the ratio of metal powder.

N-end Rule-Mediated Proteasomal Degradation of ATGL Promotes Lipid Storage.

Cellular lipid storage is regulated by the balance of lipogenesis and lipolysis. The rate-limiting triglyceride hydrolase ATGL (desnutrin/PNPLA2) is critical for lipolysis. The control of ATGL transcription, localization, and activation has been intensively studied, while regulation of the protein stability of ATGL is much less explored.

Liquid-Phase-Assisted Catalytic Nitridation of Silicon and In Situ Growth of α-SiN.

SiN powders were synthesized with Fe, Co, or Ni as catalysts using Si powder at 1250 °C in a nitrogen atmosphere by liquid-phase-assisted catalytic nitridation synthesis (LPA-CNS). The catalytic effects of the metals on the nitridation of silicon powder were investigated by mixing the powder with 2 wt% by mass of Fe, Co, or Ni in a high-temperature liquid phase in flowing nitrogen. The α-SiN micro-morphology could be effectively changed by adjusting the type of catalyst in the initial reaction mixtures.

NiP nanocrystals embedded Ni-MOF nanosheets supported on nickel foam as bifunctional electrocatalyst for urea electrolysis.

It's highly desired but challenging to synthesize self-supporting nanohybrid made of conductive nanoparticles with metal organic framework (MOF) materials for the application in the electrochemical field. In this work, we report the preparation of NiP embedded Ni-MOF nanosheets supported on nickel foam through partial phosphidation (NiP@Ni-MOF/NF). The self-supporting NiP@Ni-MOF/NF was directly tested as electrode for urea electrolysis.

Enhancing fatty acid oxidation negatively regulates PPARs signaling in the heart.

High fatty acid oxidation (FAO) is associated with lipotoxicity, but whether it causes lipotoxic cardiomyopathy remains controversial. Molecular mechanisms that may be responsible for FAO-induced lipotoxic cardiomyopathy are also elusive. In this study, increasing FAO by genetic deletion of acetyl-CoA carboxylase 2 (ACC2) did not induce cardiac dysfunction after 16 weeks of high fat diet (HFD) feeding.

A lipid droplet-associated GFP reporter-based screen identifies new fat storage regulators in C. elegans.

Fat storage disorders including obesity are pandemic human health problems. As a genetically amenable model organism, Caenorhabditis elegans has often been used to explore the molecular mechanisms of fat storage regulation. Dye staining of fixed animals and stimulated Raman scattering (SRS) microscopy methods have been used successfully to study fat storage, but a genetic screening system that takes full advantage of C.

Proteomic study and marker protein identification of Caenorhabditis elegans lipid droplets.

Lipid droplets (LDs) are a neutral lipid storage organelle that is conserved across almost all species. Many metabolic syndromes are directly linked to the over-storage of neutral lipids in LDs. The study of LDs in Caenorhabditis elegans (C.