RNA-seq analysis and lipid profiling reveal the competitive regulation of starch and triacylglycerol synthesis during grain-filling stage in tetraploid rice.

Autotetraploid rice is a useful germplasm for polyploid rice breeding in improving nutritional values. Nevertheless, underlying mechanism of starch and lipid accumulation in tetraploid rice caryopsis remains largely unknown. Here, regulatory mode of starch and triacylglycerol (TAG) synthesis during grain-filling stage in diploid and tetraploid indica rice varieties 9311 was investigated.

Macro-Superlubricity Induced by Tribocatalysis of High-Entropy Ceramics.

Macroscale superlubricity has attracted considerable attention as a promising strategy to minimize frictional energy dissipation and achieve near-zero wear. However, realizing macroscale superlubricity with prolonged durability remains an immense challenge, particularly on engineering steels. Current superlubricants render steel surfaces susceptible to corrosion, causing severe wear and superlubrication failure.

CD49a Targeting Enhances NK Cell Function and Antitumor Immunity.

Approximately 70% of patients receiving immune checkpoint blockade therapies develop treatment resistance. Thus, there is a need for the identification of additional immunotherapeutic targets. CD49a is a membrane protein expressed on NK cells and T cells.

Selective Methods Promote Protein Solid-State NMR.

Solid-state nuclear magnetic resonance (ssNMR) is indispensable for studying the structures, dynamics, and interactions of insoluble proteins in native or native-like environments. While ssNMR includes numerous nonselective techniques for general analysis, it also provides various selective methods that allow for the extraction of precise details about proteins. This perspective highlights three key aspects of selective methods: selective signals of protein segments, selective recoupling, and site-specific insights into proteins.

Occlusion of vertebral artery and anterior spinal artery in cervical facet dislocation: a prospective study using computed tomography angiography.

Study Design: A prospective study.

Objective: To investigate the incidence of vertebral artery (VA) occlusion and whether anterior spinal artery (ASA) is occluded in cervical facet dislocation.

Setting: University hospital, China.

Understanding the CO capture reaction through electronic structure analysis of four-membered-ring group-13/N- and B/group-15-based Lewis acid-base pairs.

Incomplete combustion yields a significant byproduct, known for its high toxicity to humans: gas phase carbon monoxide (CO). This study utilized several advanced theoretical methods to examine the factors contributing to the activation energy involved in CO capture by a frustrated Lewis pair (FLP) and to forecast the potential success of the CO capture reaction. The current theoretical findings indicate that among the four-membered-ring Group-13/N-FLP and B/Group-15-FLP molecules, only the B/N-based FLP-type molecule effectively captures CO, considering both thermodynamics and kinetics.

PD-1 Inhibitors Combined with Tyrosine Kinase Inhibitors with or without Hepatic Artery Infusion Chemotherapy for the First-Line Treatment of HBV-Related Advanced Hepatocellular Carcinoma: A Retrospective Study.

Purpose: Comparing the efficacy and safety of programmed cell death protein-1 (PD-1) inhibitors combined with tyrosine kinase inhibitors (TKIs) with or without hepatic artery infusion chemotherapy (HAIC) in HBV-related advanced HCC and exploring prognostic predictors of the combined regimen.

Patients And Methods: A total of 194 patients diagnosed with HBV-related advanced HCC between 2020 and 2022 were included in the study, including 99 in the HAIC combined with PD-1 inhibitors plus TKIs (HPT group) and 95 in the PD-1 inhibitors plus TKIs (PT group). The efficacy was evaluated according to the tumor response rate and survival, and the safety was evaluated according to the adverse events.

Understanding the Impact of Group 14 Elements on the Reactivity of [1 + 2] Cycloaddition Reaction between a Cyclic (Alkyl)(amino)carbene Analogue with a Group 14 Element and a Heavy Acetylene Molecule.

Computational exploration using the density functional theory framework (M06-2X-D3/def2-TZVP) was undertaken to investigate the [1 + 2] cycloaddition reaction between a five-membered-ring heterocyclic carbene analogue (; G14 = group 14 element) and a heavy acetylene molecule (). It was theoretically observed that exclusively , , and demonstrate the capacity to participate in the [1 + 2] cycloaddition reaction with the triply bonded . In addition, only three heavy acetylenes (, , and ) can catalyze the [1 + 2] cycloaddition reaction with .

Delayed postoperative neurological deficits from scoliosis correction: a case series and systematic review on clinical characteristics, treatment, prognosis, and recovery.

Objective: This study was designed to investigate the clinical features, treatment modalities, and risk factors influencing neurological recovery in patients who underwent scoliosis correction with delayed postoperative neurological deficit (DPND).

Methods: Three patients with DPND were identified from 2 central databases for descriptive analysis. Furthermore, all DPND cases were retrieved from the PubMed and Embase databases.

Insights into diversity: Probing the contrasts between Steud and Hayata.

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Evaluation of models to predict prognosis in patients with advanced hepatocellular carcinoma treated with TACE combined with apatinib.

Background: The HAP, Six-and-Twelve, Up to Seven, and ALBI scores have been substantiated as reliable prognostic markers in patients presenting with intermediate and advanced hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) treatment. Given this premise, our research aims to assess the predictive efficacy of these models in patients with intermediate and advanced HCC receiving a combination of TACE and Apatinib. Additionally, we have conducted a meticulous comparative analysis of these four scoring systems to discern their respective predictive capacities and efficacies in combined therapy.

Spatiotemporal patterns and drivers of the urban air pollution island effect for 2273 cities in China.

Air pollution levels tend to be higher in urban areas than in surrounding rural areas, and this air pollution has a negative effect on human health. However, the spatiotemporal patterns of urban-rural air pollution differences and the determinants of these differences remain unclear. Here, we calculate the Urban Air Pollution Island (UAPI) intensity for PM and PM on a monthly, seasonal, and annual scale for 2273 cities in China from 2000 to 2020.

NHC-Silyliumylidene Cation-Catalyzed Hydroboration of Isocyanates with Pinacolborane.

The low-oxidation-state silicon-catalyzed hydroboration of isocyanates with pinacolborane (HBpin) using the NHC-silyliumylidene cation catalyst [(IMe)SiH]I (, IMe = :C{N(Me)C(Me)}) is described. In the catalysis, the Si lone pair electrons activate isocyanates, and the latter react with HBpin to form -boryl formamides at room temperature. Catalyst further activates -boryl formamides at 70 °C, the intermediates of which react with HBpin to form -boryl methylamines and (pinB)O.

The OsTIL1 lipocalin protects cell membranes from reactive oxygen species damage and maintains the 18:3-containing glycerolipid biosynthesis under cold stress in rice.

Lipocalins constitute a conserved protein family that binds to and transports a variety of lipids while fatty acid desaturases (FADs) are required for maintaining the cell membrane fluidity under cold stress. Nevertheless, it remains unclear whether plant lipocalins promote FADs for the cell membrane integrity under cold stress. Here, we identified the role of OsTIL1 lipocalin in FADs-mediated glycerolipid remodeling under cold stress.

Recent advances in natural polysaccharides against hepatocellular carcinoma: A review.

Hepatocellular carcinoma (HCC) is a malignant tumor of the digestive system that poses a serious threat to human life and health. Chemotherapeutic drugs commonly used in the clinic have limited efficacy and heavy adverse effects. Therefore, it is imperative to find effective and safe alternatives, and natural polysaccharides (NPs) fit the bill.

Comparison of the effectiveness of chemotherapy combined with immunotherapy and chemotherapy alone in advanced biliary tract cancer and construction of the nomogram for survival prediction based on the inflammatory index and controlling nutritional status score.

Objective: To analyze the effectiveness of combining immune checkpoint inhibitors (ICIs) with first-line therapy in patients with advanced biliary tract cancer (BTC) and explore the biomarkers affecting the prognosis of immunotherapy, to construct a nomogram for the prediction of survival.

Methods: A retrospective study was conducted to include a total of 209 patients with advanced BTC treated in the first line from 2018 to 2022, divided into a combination therapy group (n = 129) and a chemotherapy-only group (n = 80) according to whether ICIs were applied in combination. Univariate and multifactorial COX regression analyses were performed on variables that may affect prognosis to identify independent influences on patient prognosis, and this was used to create nomograms, which were then prospectively validated and calibrated.

Reactivity of the Intramolecular Vicinal Group-13/P- and B/Group-15-Based Frustrate Lewis Pairs with Sulfur Dioxide: Mechanistic Insight from DFT.

The emission of SO gas by industrialized societies contributes to the occurrence of acid rain in natural environments. In this study, we put forward a theoretical investigation into the capture reactions of SO. Our analysis centers on the energy profiles of intramolecular 1,2-cyclohexylene-bridged FLP-associated molecules.

Efficacy and safety analysis of chemotherapy combined with immunotherapy compared with standard chemotherapy for advanced biliary tract malignant tumors.

Objective: The treatment of biliary tract (BTC) cancer remains relatively limited, especially in the setting of advanced BTC. Immune checkpoint inhibitors (ICIs) have shown some effects in a variety of solid tumors, but their efficacy and safety in patients with advanced BTC are still elusive, which require in-depth analysis.

Methods: The clinical information of 129 patients diagnosed with advanced BTC between 2018 and 2021 were retrospectively reviewed.