Publications by authors named "Zheng-yun Chu"
As a folk medicinal plant, has been used for the treatment of cancer in China and Korea. Traditionally, is decocted together with chicken eggs. Both the decoction and medicated eggs possess anti-tumor properties.
View Article and Find Full Text PDFBerberine is an isoquinoline alkaloid widely used in the treatment of microbial infections. Recent studies have shown that berberine can enhance the inhibitory efficacy of antibiotics against clinical multi-drug resistant isolates of methicillin-resistant Staphylococcus aureus (MRSA). However, the underlying mechanisms are poorly understood.
View Article and Find Full Text PDFRole of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma.
Biomed Res Int
October 2016
Article Synopsis
- Baicalin (BA), a flavonoid from Scutellaria baicalensis, shows strong antiviral effects, particularly against the influenza virus A/PR/8/34 (H1N1).
- The study highlights that BA protects mice from infection by increasing IFN-γ production, but is ineffective in mice lacking IFN-γ or its receptor.
- Additionally, BA stimulates human T cells and natural killer (NK) cells to produce IFN-γ and activates the JAK/STAT-1 signaling pathway, confirming its antiviral potential both in vitro and in vivo.
Article Synopsis
- Nano-TiO2 is used in automobile exhaust systems to reduce harmful nitric oxide (NO) emissions, which also plays a role in vasodilation and swelling in the human body.
- Recent research shows that nano-TiO2 can significantly lower NO production in mouse macrophages, suggesting its potential as a deswelling agent.
- The development of a nano-TiO2 ointment demonstrated similar effects in reducing swelling, highlighting its promise for treating diseases associated with edema.
Article Synopsis
- - The study aimed to create a unique HPLC fingerprint for Polygonum orientale inflorescence to aid in its quality assessment.
- - HPLC analysis identified 18 peaks in samples from 12 different locations, with four key compounds being successfully recognized, including taxifolin and catechin.
- - The method demonstrated high reproducibility and specificity, making it a reliable tool for identifying and controlling the quality of Polygonum orientale inflorescence.
Role of berberine in anti-bacterial as a high-affinity LPS antagonist binding to TLR4/MD-2 receptor.
BMC Complement Altern Med
March 2014
Background: Berberine is an isoquinoline alkaloid mainly extracted from Rhizoma Coptidis and has been shown to possess a potent inhibitory activity against bacterial. However, the role of berberine in anti-bacterial action has not been extensively studied.
Methods: The animal model was established to investigate the effects of berberine on bacterial and LPS infection.
To investigate the antioxidant effect of vitexin-4''-O-glucoside, a flavone glycoside, isolated from the leaves of Crataegus pinnatifida Bge. var. major, we developed a simple and sensitive high-performance liquid chromatography (HPLC) method to determine levels of malondialdehyde (MDA) in ECV304 cell culture medium after induction by tert-butyl-hydroperoxide (TBHP).
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the antiviral effects of baicalin on mice infected with the influenza virus (A/FM/1/47) to determine its protective and healing capabilities.
- - One group of mice received baicalin two days before infection, while another group was treated one day after infection, allowing for a comparison of baicalin's effects.
- - Results showed that baicalin significantly increased survival time, eliminated the virus in the lungs, reduced infection severity, and improved lung health in the infected mice.
Objective: To study the extract of compound Radix Scutellariae on inhibiting the mRNA replication and inducing the INF expression of influenza virus in mice's vivo.
Methods: Influenza virus infected mice pneumono-adaption stock A/FM/1/47 (H1N1) evoked mice pneumonia taken as animal model. RT-PCR was adopted to measure the content of influenza virus's mRNA and INF in mice to study the effect of the extract on mRNA replication and IFN expression.