Expression and clinical significance of VISTA, B7-H3, and PD-L1 in glioma.

Immune checkpoint (IC) therapy has led to a breakthrough in cancer treatment. However, the interaction of ICs is controversial in glioma. We detected features of ICs using transcriptome data and a multicolor immunofluorescence assay.

Male adolescents with Interleukin 10 rs1800872 AA genotype had higher prevalence and slower recoveries of post-traumatic stress disorder at late stage of a follow-up.

Background: Pathophysiological mechanisms of post-traumatic stress disorder (PTSD) are elusive and heterogeneous relationships have been reported among PTSD, Interleukin 10 (IL-10), and other factors after stresses. The present study aimed to longitudinally investigate associations of PTSD with environmental factors and genetic variation of rs1800872 at IL-10 gene.

Methods: Symptoms of PTSD were measured by PTSD Checklist-Civilian Version (PCL-C) in 462 high school students at 6, 12, and 18 months after Wenchuan earthquake in China.

Synthesis, structure and photocatalytic property of a novel Zn(II) coordination polymer based on in situ synthetized pyridine-3,4-dicarboxylhydrazidate ligand.

One new pyridine-3,4-dicarboxylhydrazidate-coordinated compound [Zn(pdh)] 1 (pdh = pyridine-3,4-dicarboxylhydrazidate) was obtained under the hydrothermal conditions. Noteworthily, the pdh molecules in the title compound originated from the ligand in situ reaction between organic pyridine-3,4-dicarboxylic acid (pdca) and NH·HO. X-ray single-crystal diffraction analysis revealed that the pdh ligands exhibit a special μ-bridging mode in compound 1, which link Zn(II) centers into a 2D layered structure.

[Correlation of Gene Mutations with the Protein Expressions of TAK1 and MAP4K2 in Colorectal Cancer].

Objective: To analyze the correlation of gene mutations with the protein expressions of transforming growth factor-β activating kinase 1 (TAK1) protein and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) protein in colorectal cancer.

Methods: gene mutations were detected by DNA sequencing analysis, and the expressions of TAK1 protein and MAP4K2 protein were detected by immunohistochemical method in 76 cases of colorectal cancer tissues.

Results: In 76 cases of colorectal cancer tissues, the mutation rate of gene was 32.

EEG coherence characteristics at rest and during a three-level working memory task in normal aging and mild cognitive impairment.

Background: The aim was to examine and compare the characteristics of intra- and inter-hemispheric EEG coherence in patients with mild cognitive impairment (MCI) and healthy controls at rest and during a working memory (WM) task having three levels.

Material/methods: The subjects included 35 patients with MCI according to the DSM-IV criteria (mean age: 62.3+/-6.

Alpha spectral power and coherence in the patients with mild cognitive impairment during a three-level working memory task.

Objective: The functional relationship between calculated alpha band spectral power and inter-/intra-hemispheric coherence during a three-level working memory task of patients with mild cognitive impairment (MCI) was investigated.

Methods: Subjects included 35 MCI patients according to the DSM-IV criteria (mean age: 62.3, SD: 6.

Inter- and intra-hemispheric EEG coherence in patients with mild cognitive impairment at rest and during working memory task.

Objective: To assess functional relationship by calculating inter- and intra-hemispheric electroencephalography (EEG) coherence at rest and during a working memory task of patients with mild cognitive impairment (MCI).

Methods: The sample consisted of 69 subjects: 35 patients (n=17 males, n=18 females; 52-71 years old) and 34 normal controls (n=17 males, n=17 females; 51~63 years old). Mini-mental state examination (MMSE) of two groups revealed that the scores of MCI patients did not differ significantly from those of normal controls (P>0.

Study on EEG power and coherence in patients with mild cognitive impairment during working memory task.

To investigate the features of electroencephalography (EEG) power and coherence at rest and during a working memory task of patients with mild cognitive impairment (MCI). Thirty-five patients (17 males, 18 females; 52-71 years old) and 34 sex- and age-matched controls (17 males, 17 females; 51-63 years old) were recruited in the present study. Mini-Mental State Examination (MMSE) of 35 patients with MCI and 34 normal controls revealed that the scores of MCI patients did not differ significantly from those of normal controls (P>0.

Abnormal cortical functional connections in Alzheimer's disease: analysis of inter- and intra-hemispheric EEG coherence.

To investigate inter- and intra-hemispheric electroencephalography (EEG) coherence at rest and during photic stimulation of patients with Alzheimer's disease (AD). Thirty-five patients (12 males, 23 females; 52 to approximately 64 y) and 33 sex- and age-matched controls (12 males, 21 females; 56 to approximately 65 y) were recruited in the present study. EEG signals from C3-C4, P3-P4, T5-T6 and O1-O2 electrode pairs resulted from the inter-hemispheric action, and EEG signals from C3-P3, C4-P4, P3-O1, P4-O2, C3-O1, C4-O2, T5-O1 and T6-O2 electrode pairs resulted from the intra-hemispheric action.