Publications by authors named "Zheng-xia Zhang"
A non-ionic water-soluble galactomannan, isolated from the seed endosperm of Crotalaria mucronata Desv., may be an ideal thickener to increase food viscosity. The present study hypothesized that the viscous property of Crotalaria galactomannan may be associated with its spatial structure.
View Article and Find Full Text PDFObjective: Airway remodeling in asthma makes treatment of asthma very difficult, and study of its pathogenesis becomes very important. The present study aimed to explore the role of external signal regulated kinase (ERK) signal transduction pathway in airway remodeling in rats asthma model and regulatory effects of glucocorticoids on ERK signal transduction pathway and airway remodeling.
Methods: Totally 80 male Sprague-Dawlay rats (6-8 weeks old, weighing about 120 g) were randomly divided into control groups (30 rats), asthma groups (30 rats) and treated groups [including a group intervened with dexamethasone (DM group) and budesonide (BUD group), each had 10 rats].
Article Synopsis
- - The study aimed to identify the cause of acute lower respiratory tract infections (LRTI) in children in Wenzhou City, focusing on both viral and bacterial agents as well as antibiotic resistance patterns in the pathogens.
- - Researchers collected respiratory secretions from 454 children aged 1 month to 10 years and found that viral infections (especially Respiratory syncytial virus, RSV) were common, occurring in 50.4% of cases, while bacterial infections occurred in 29.7% of cases.
- - Among the identified bacterial pathogens, Klebsiella pneumoniae and E.coli showed high rates of antibiotic resistance, with 42.2% and 65.0% respectively being extended-spectrum
Objective: To study the expression of signal transducer and activator of transcription 6 and its mRNA in rat asthma model and the modulatory effect of dexamethasone (DXM).
Methods: Thirty male SD rats were randomly divided into three groups: the control group, asthma group and DXM group. The rats in each group were sacrificed 24 h after the last challenge.
Objective: To study the effect of macrophage inflammatory protein-1alpha(MIP-1alpha) and its mRNA on airway inflammation of mouse with induced asthma.
Methods: Seventy male BALB/C mice were randomly divided into the control group and asthma group (including 7 subgroups, 10 mice each). The control group included group A(24) (the lavaging subgroup was sacrificed 24 h after the last challenge) and group A(0) (the non-lavaging subgroup was sacrificed from 18 h to 24 h after the last challenge); asthma group included group B(3) (the lavaging subgroup was sacrificed 3 h after the last challenge), group B(8) (the lavaging subgroup was sacrificed 8 h after the last challenge), group B(24) (the lavaging subgroup was sacrificed 24 h after the last challenge), group B(36) (the lavaging subgroup was sacrificed 36 h after the last challenge) and group B(0) (the non-lavaging subgroup was sacrificed from 18 h to 24 h after the last challenge).
Article Synopsis
- The study investigates children's diaphragmatic fatigue using ribcage-abdomen motion analysis, aiming to simplify diagnosis without expensive equipment.
- It involved 53 children with respiratory issues, measuring asynchrony in their ribcage and abdomen movements using impedance respirography.
- Findings showed three distinct types of asynchronized respiratory motions, each with specific characteristics and levels of M, correlating well with traditional two-dimensional measurement methods.
Objective: Asthma is a chronic respiratory tract disorder characterized by airway hyperreaction (AHR), persistent airway inflammation, high serum IgE, overproduction of IL-4, IL-5 and IL-13 by allergen-specific Th2 cells. The morbidity and mortality of asthma have continued to increase despite the use of currently available therapeutic agents. The reputed effects of traditional Chinese medicines (TCMs) have led to increasing use of TCMs for treatment of asthma throughout the world.
View Article and Find Full Text PDF[Effect of shenmai injection on diaphragmatic fatigue in children with respiratory failure].
Zhongguo Zhong Xi Yi Jie He Za Zhi
June 2002
Objective: To study the effect of Shenmai injection (SMI) on diaphragmatic fatigue in children with respiratory failure.
Methods: Thirty-five cases of children respiratory failure with diaphragmatic fatigue were divided into two groups. The control group was treated with comprehensive therapy including anti-infection, oxygen inhalation and parenteral nutrition, etc.