Publications by authors named "Zheng-ping Chen"
Article Synopsis
- Recurrent aphthous stomatitis (RAS) is a common mouth disease that affects 5% to 25% of people, but scientists don’t fully understand why it happens.
- In this study, researchers used special computer tools to analyze genes in people with RAS to find possible new treatments.
- They discovered 915 genes that are different in people with RAS and identified some specific ones (like FBXO6, ITGA4, and VCAM1) as possible targets for new medicines.
[Mechanism of tanshinone II A in inhibiting transformation of aortic valvular myofibroblast to osteoblast-like phenotype].
Zhongguo Zhong Yao Za Zhi
September 2015
Aortic valve calcification (AVC) is a pathological process correlated with multiple disease causes and actively regulated by cardiac valve cells. In this study, porcine aortic valve myofibroblasts cultured in vitro were treated with 50 μg z L(-1) of pathological factor tumor necrosis factor α (TNF-α). Tanshinone II A (TSN) with the concentration of 50 mg x L(-1) and TNF-α were combined in incubating cells for 72 h (3 d) and 120 h (5 d).
View Article and Find Full Text PDFEffects of oxidized low density lipoprotein on transformation of valvular myofibroblasts to osteoblast-like phenotype.
J Huazhong Univ Sci Technolog Med Sci
June 2015
Article Synopsis
- Researchers studied how the Wnt signaling pathway affects the transformation of cardiac valvular myofibroblasts into osteoblast-like cells using porcine aortic valve myofibroblasts exposed to oxidized low-density lipoprotein (ox-LDL).
- The study involved four groups based on the duration of ox-LDL treatment, measuring the expression of specific proteins like α-SMA, BMP2, ALP, and Cbfa-1, finding that their levels significantly increased over time with ox-LDL exposure.
- Blocking the Wnt pathway with Dickkopf-1 led to a decrease in the expression of these proteins, indicating that the Wnt/β-catenin signaling pathway plays
Background: Recent studies have reported contrasting results regarding the association of polymorphisms in two integrin genes, ITGA2 and ITGB3, with ischemic stroke.
Aims: The present study aimed to investigate the correlation between the ITGA2 C807T and ITGB3 T176C polymorphic loci with ischemic stroke, as well as plasma lipid and lipoprotein levels.
Study Design: Case control study.
Objective: To discuss the causes for changes of opinions in reappraisals of mental disabilities due to traffic accidents.
Methods: Fifty-one reappraisals of mental disorders due to traffic accidents from October 2009 to October 2011 in the Institute of Forensic Science, Shaoxing Seventh People's Hospital, were retrospectively analyzed.
Results: In the reappraisals, the opinions about disability grade changed in 30 cases (58.
Single nucleotide polymorphisms in the promoter region of interleukin-18 (IL-18), an inflammatory cytokine, have been linked to susceptibility to many diseases, including cancer and immune dysfunction. Here, we explored the potential association between the IL-18 -607C/A (rs1946518) promoter region polymorphism and susceptibility to ischemic stroke (IS). This locus was amplified from peripheral blood samples of 386 IS patients (cases) and 364 healthy individuals (controls) by the polymerase chain reaction with sequence-specific primers.
View Article and Find Full Text PDFIn the mol-ecule of the title compound, C(10)H(11)NO(4), the nitro group is approximately coplanar with the benzene ring [dihedral angle = 4.57 (10)°], while the carboxyl-ate group is slightly twisted, making an angle of 12.16 (8)°.
View Article and Find Full Text PDF2Beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(2-[(18)F]fluoroethyl)nortropane ((18)F-FECNT) is a potential dopamine transporter imaging agent. In this article, a new mesylate precursor was prepared and a one-step automated synthesis of (18)F-FECNT was developed. The mesylate precursor (4) was synthesized from 2beta-carbomethoxy-3beta-(4-chlorophenyl)tropane (1) by N-demethylation, hydroxyethylation followed by mesylation at a total yield of 47%.
View Article and Find Full Text PDF(2S,3S)-3-(4-Chloro-phen-yl)-8-methyl-tropane-2-carboxylic acid.
Acta Crystallogr Sect E Struct Rep Online
August 2008
Article Synopsis
- - The compound C(15)H(18)ClNO(2) features a tropane ring with torsion angles similar to those found in cocaine and its derivatives.
- - An intra-molecular hydrogen bond exists between the nitrogen atom in the tropane ring and the oxygen atom of a carboxyl group.
- - The crystal structure is strengthened by weak C-H⋯O interactions among molecules in the ab plane, creating a two-dimensional supramolecular network.
To investigate the usefulness of 18F-FP-CIT PET for assessing the severity of Parkinson's disease (PD) at various clinical stages, 41 patients with PD were divided into early (Hoehn&Yahr I-II, n = 23) and advanced (Hoehn & Yahr III-IV, n = 18) subgroups. 18F-FP-CIT PET was performed in these patients and 12 normal subjects. 18F-FP-CIT uptake in striatal subregions and its correlation with UPDRS were first evaluated by ROI analysis, and between-group differences were also analyzed by Statistical Parametric Mapping (SPM).
View Article and Find Full Text PDF[Therapeutic study of autologous Schwann cells' bridge graft into the brain of hemiparkinsonian monkey].
Zhonghua Yi Xue Za Zhi
February 2004
Objective: To evaluate the therapeutic effect of autologous transplantation of Schwann cells as "bridge" between the medial forebrain bundle (MFB) and caudate nucleus, into the brain of hemiparkinsonian monkey.
Methods: Six monkeys were used following 6-OHDA-induced hemiparkinsonism. Three of them were autologous transplanted using Schwann cells as "bridges" between MFB and caudate nucleus.