Effect of alloxan time administerDrug on establishing diabetic rabbit model.

Aim: To explore the effect of alloxan time administerDrug on establishing diabetic rabbit model.

Methods: Thirty-six healthy rabbits, weighed 2-2.5kg, were randomly divided into one time administerDrug group (Group A, n=12), two times administerDrug group (Group B, n=12) and three times administerDrug group(Group C, n=12).

Production and enhanced biological activity of a novel GHRH analog, hGHRH with an N-terminal Pro-Pro extension.

Growth Hormone Releasing Hormone (GHRH) is one of the most important hormones in life. Because of its potential clinical importance, its short half-life, and its expensive chemical synthesis, an analog of hGHRH with a prolonged half-life and better activity has been studied for clinical application, especially for the treatment of muscle wasting, type II diabetes, or sleep disorders. The Pro-Pro-hGHRH(1-44) peptide has better activity.