Modeling epidemic in metapopulation networks with heterogeneous diffusion rates.

In this paper, the process of the infectious diseases among cities is studied in metapopulation networks. Based on the heterogeneous diffusion rate, the epidemic model in metapopulation networks is established. The factors affecting diffusion rate are discussed, and the relationship among diffusion rate, connectivity of cities and the heterogeneity parameter of traffic flow is obtained.

The Effect of Prescription on the Framework of Lipid Matrix and In Vitro Properties.

Purpose: To clarify the inner framework and relative properties in vitro of Lyotropic liquid crystal (LLC) based on various prescriptions by using hydrophilic sinomenine hydrochloride (SH) and lipophilic cinnamaldehyde (CA) as model drugs.

Methods: Phase structures were checked by polarized light microscopy (PLM) and small-angle X-ray scattering (SAXS). Rheological studies and Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) analysis were carried out to reveal their molecular interactions.

On the Structure and Transdermal Profile of Liquid Crystals Based on Phytantriol.

Background: There has been a growing concern in transdermal drug technology over the past several decades. As a novel transdermal delivery system, Lyotropic liquid crystals (LLC) still face challenges such as drug loading, limited drug permeation and instability of systems. LLC system is so sensitive that a very subtle change in composition may induce a phase transformation or conversion of spatial configuration, and result in a diverse percutaneous delivery subsequently.

[Rheological properties of sinomenine in situ liquid crystal as liquid embolic agent].

Three different kinds of sinomenine in situ liquid crystal were prepared for different prescriptions, to investigate the rheological properties before and after in situ treatment and evaluate its feasibility for embolization. Rheological experiments were carried out with cone plate fixtures. Both the steady-state rheological and non-steady-state rheological properties of in-situ gels and the swelling gels were studied and compared.

ROR1 is a novel prognostic biomarker in patients with lung adenocarcinoma.

Currently, there is no reliable biomarker to clinically predict the prognosis of lung adenocarcinoma (ADC). The receptor-tyrosine-kinase like orphan receptor 1 (ROR1) is reported to be overexpressed and associated with poor prognosis in several tumors. This study aimed to examine the expression of ROR1 and evaluate its prognostic significance in human lung ADC patients.

Annoyance and activity disturbance induced by high-speed railway and conventional railway noise: a contrastive case study.

Background: High-speed railway (HR, Electrified railway with service speed above 200 km/h.) noise and conventional railway (CR, Electrified railway with service speed under 200 km/h.) noise are different in both time and frequency domain.

[Study on the soil salinization monitoring based on synthetical hyperspectral index].

The present paper selected the spectral reflectivity of saline soil and vegetation of Weigan-Kuqa River Delta Oasis in the northern margin of the Tarim Basin in Xinjiang as objects, and used various spectral transforms to process the data with continum removed methods, derivate spectra, reciprocal, first order differential and root mean square etc, then analyzed the spectrum features and decided the most sensitive band ranges most relevant to salinization, and used field hyperspectral vegetation index, soil salinity index and measured synthetical spectral index to respectively establish hyperspectral quantitative models which could evaluate the soil salinization degrees. By comparing various spectral transformations of hyperspectral data the result showed that the first derivative of measured soil and vegetation hyperspectral were most sensitive to soil salinization degrees. The hyperspectral quantitative model based on measured synthetical spectral index could monitor soil salinization accurately and was better than the models simply based on vegetation index or soil salinity index.

Aircraft noise exposure affects rat behavior, plasma norepinephrine levels, and cell morphology of the temporal lobe.

In order to investigate the physiological effects of airport noise exposure on organisms, in this study, we exposed Sprague-Dawley rats in soundproof chambers to previously recorded aircraft-related noise for 65 d. For comparison, we also used unexposed control rats. Noise was arranged according to aircraft flight schedules and was adjusted to its weighted equivalent continuous perceived noise levels (L(WECPN)) of 75 and 80 dB for the two experimental groups.

Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer.

Metastatic breast cancers are hard to treat and almost always fatal. Chloroquine diphosphate, a derivative of quinine, has long been used as a potent and commonly used medicine against different human diseases. We therefore investigated the effects of chloroquine diphosphate on a highly metastatic mouse mammary carcinoma cell line.

Barbigerone, a natural isoflavone, induces apoptosis in murine lung-cancer cells via the mitochondrial apoptotic pathway.

Barbigerone is a naturally occurring isoflavone with antioxidant activity. In present study, we investigated the antitumor activity of barbigerone against murine lung cancer cells LL/2 and the possible mechanism in vitro. Our results showed that barbigerone inhibited LL/2 cells proliferation in a concentration- and time-dependent manner and caused apoptotic death of LL/2 cells.

Cell growth inhibition, G2/M cell cycle arrest, and apoptosis induced by chloroquine in human breast cancer cell line Bcap-37.

Chloroquine is an antimalarial drug that has been used in the treatment and prophylaxis of malaria since the 1950s. The present study was undertaken to examine the effects of chloroquine on Bcap-37 human breast cancer cells' growth, cell cycle modulation, apoptosis induction, and associated molecular alterations in vitro. The chloroquine treatment decreased the viability of Bcap-37 cells in a concentration- and time-dependent manner, which correlated with G(2)/M phase cell cycle arrest.

[Optimally control urban railway noise by sound propagation path].

In order to control railway noise pollution in urban areas, the residential district located near the Zhegan railway in Hangzhou urban was taken for example, and some controlling measures were proposed based on the investigation in railway noise impact as well as the planning of the district, the environmental scene and the project devises. The measures included setting man-made soil slopes, noise barriers and virescence. Combining some of them could be a typical noise reduction scheme.

[Effects of chloroquine diphosphate on proliferation and apoptosis of human leukemic K562 cells].

The purpose of this study was to investigate the effects of chloroquine diphosphate on the proliferation and apoptosis of human leukemic K562 cells, and to elucidate its possible mechanism of activity. The inhibitory effect of chloroquine diphosphate with different concentrations on K562 cell proliferation was detected by MTT method. Apoptosis was measured by flow cytometry (FCM); morphological analysis of apoptosis was performed after staining with propidium iodide (PI) under fluorescence microscope; cell apoptosis was assessed by the DNA ladder shown agarose gel electrophoresis.