Publications by authors named "Zheng-Yuan Yu"
Background: Breast cancer is a highly heterogeneous disease. Early-stage, non-metastatic breast cancer is considered curable after definitive treatment. Early detection of tumor recurrence and metastasis through sensitive biomarkers is helpful for guiding clinical decision-making and early intervention in second-line treatment, which could improve patient prognosis and survival.
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- - Keloids are benign skin tumors unique to different ethnicities, and this study aims to explore the molecular mechanisms behind keloid formation in the Chinese population using whole-exome sequencing.
- - Researchers analyzed samples from 9 keloid patients, identifying over 3,000 single nucleotide variants and many copy number variations, with certain genes like MUC4 showing the highest mutation rates.
- - The findings suggest that keloid-related mutations mainly affect cancer-related pathways, particularly involving micro RNAs and calcium signaling, enhancing our understanding of keloid development and potential treatments.
Background: With the development of gene-sequencing technology, genome biomarkers, including Erb-B2 receptor tyrosine kinase 2 (ERBB2), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pIK3CA), BReast CAncer gene 1 (BRCA1), and BReast CAncer gene 2 (BRCA2), and immunomarkers, including the tumor mutational burden (TMB) and programmed death-ligand 1 (PD-L1), have become important in the selection of treatment.
Methods: Twenty patients with early stage breast cancer who underwent surgery were enrolled in this study. Tissue samples and paired postoperative peripheral blood samples were collected and subjected to the targeted-capture sequencing of 1,021 cancer-associated genes.
Article Synopsis
- Liver metastasis from colorectal cancer (CRC) significantly contributes to CRC-related deaths, but its molecular mechanisms remain largely unclear.
- The study utilized whole-exome sequencing on tissue samples from four CRC patients to identify genetic variations and analyze bioinformatics data.
- Key findings include the identification of 8,565 single nucleotide variants and 429 insertions/deletions, with high mutation frequencies in genes like TTN, OBSCN, and HIPK2, indicating potential pathways involved in liver metastasis.
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly malignant tumors worldwide due to its ineffective diagnosis and poor prognosis. The longest median overall survival (OS) to PDAC patients has been provided by FOLFIRINOX. It is essential to identify the mechanisms of FOLFIRINOX to gain new insights for the treatment of PDAC.
View Article and Find Full Text PDFThis study aimed to explore the effect of erythropoietin (EPO) on brain tissue after traumatic brain injury in rats. Animals were divided into sham, control and EPO groups. The model was constructed using the improved Feeney's free falling weight traumatic brain injury model.
View Article and Find Full Text PDFEpstein-Barr virus (EBV) is closely associated with several malignancies, including nasopharyngeal carcinoma. To investigate the EBV activity in tumor development, we tried to establish a malignant model of EBV-infected cells in nude mice. On the basis of the Maxi-EBV system, a human embryonic kidney epithelial cell line (293) with a low malignant potential was used for a stable EBV genome infection.
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