Chemical Constituents from Soft Coral spp. Demonstrate Antiproliferative Effects on Oral Cancer Cells.

Five new eudensamane-type sesquiterpene lactones, clasamanes A-E (-), three new dolabellane-type diterpenes, clabellanes A-C (-), and fifteen known compounds (-) were isolated from the ethanolic extract of Taiwanese soft coral spp. The structures of all undescribed components (-) were determined by analysis of IR, mass, NMR, and UV spectroscopic data. The absolute configuration of new compounds was determined by using circular dichroism and DP4+ calculations.

Marine Sponge Extract Improves Antiproliferation and Apoptosis of Breast Cancer Cells without Cytotoxicity to Normal Cells In Vitro.

The anticancer effects and mechanisms of marine sponge were rarely assessed, especially for methanol extract of (MEAS) to breast cancer cells. This study evaluated the differential suppression effects of proliferation by MEAS between breast cancer and normal cells. MEAS demonstrated more antiproliferation impact on breast cancer cells than normal cells, indicating oxidative stress-dependent preferential antiproliferation effects on breast cancer cells but not for normal cells.

Novel Aporphine- and Proaporphine-Clerodane Hybrids Identified from the Barks of Taiwanese (Sonn.) Thwaites var. with Strong Anti-DENV2 Activity.

Hybrid natural products produced via mixed biosynthetic pathways are unique and often surprise one with unexpected medicinal properties in addition to their fascinating structural complexity/diversity. In view of chemical structures, hybridization is a way of diversifying natural products usually through dimerization of two similar or dissimilar subcomponents through a C-C or N-C covalent linkage. Here, we report four structurally attractive diterpene-alkaloid conjugates polyalongarins A-D (-), clerodane-containing aporphine and proaporphine alkaloids, the first of its kind from the barks of Taiwanese (Sonn.

The correlation between multimodal radiomics and pathology about thermal ablation lesion of rabbit lung VX2 tumor.

Objective: To explore the correlation of CT-MRI pathology with lung tumor ablation lesions by comparing CT, MRI, and pathological performance of rabbit lung VX2 tumor after thermal ablation.

Methods: Thermal ablation including microwave ablation (MWA) and radiofrequency ablation (RFA) was carried out in 12 experimental rabbits with lung VX2 tumors under CT guidance. CT and MRI performance was observed immediately after ablation, and then the rabbits were killed and pathologically examined.

Spatiotemporal evolution characteristics of the late frost damage risk to shrubby tea trees in tea region, southwest China from 1971 to 2020.

Understanding the spatiotemporal evolution characteristics of the risk of late frost damage has scientific guiding significance for optimizing the regional agricultural production layout and varie-ty tuning. Based on the daily meteorological data of 65 weather stations in the southwest China tea region from 1971 to 2020, we analyzed variation characteristics of the last frost date (LFD), tea bud open date (BOD), and their relationships, constructed frost damage probability index and frost damage severity index of spring shoots of shrubby tea trees, and analyzed the spatiotemporal evolution chara-cteristics of the late frost damage risk of shrub tea trees in the southwest tea region. The results showed that both the BOD and LFD had a significant ahead of trend from 1971 to 2020 and the early rate of the LFD was relatively faster than that of the BOD in the southwest tea region.

Magnetic resonance-guided thermal ablation for small liver malignant tumor located on segment II or IVa abutting the heart: a retrospective cohort study.

Objective: This study aimed to evaluate the clinical safety and efficacy magnetic resonance (MR)-guided percutaneous thermal ablation for the treatment of small liver malignant tumors of segment II and IVa (≤3.0 cm) abutting the heart.

Method: The enrollment of 24 patients with 25 malignant liver lesions located on the II or IVa segment abutting the heart who underwent MRI-guided thermal ablation between August 2010 and February 2020 were retrospectively analyzed.

Imaging features of microwave-ablated lesions of the VX2 tumors in rabbit lungs on computed tomography and magnetic resonance images and their correlations with pathological examination.

Purpose: This study aimed to explore the accuracy of different imaging methods for lesion volume estimation pre- and post-microwave ablation (MWA) as compared with that of pathological examination.

Methods: We used the VX2 cell line to establish the VX2 lung tumor model in rabbits, followed by MWA of the tumor. The imaging features of the VX2 tumors were documented.

Open-Destination Measurement-Device-Independent Quantum Key Distribution Network.

Quantum key distribution (QKD) networks hold promise for sharing secure randomness over multi-partities. Most existing QKD network schemes and demonstrations are based on trusted relays or limited to point-to-point scenario. Here, we propose a flexible and extensible scheme named as open-destination measurement-device-independent QKD network.

Evaluation of the correlation between infrared thermal imaging-magnetic resonance imaging-pathology of microwave ablation of lesions in rabbit lung tumors.

Purpose: This study aimed to evaluate the correlation between infrared thermal imaging-magnetic resonance imaging (MRI)-pathology of microwave ablation (MWA) of lesions in rabbit lung tumors.

Materials And Methods: MR-guided MWA was performed in nine VX2 tumor-bearing rabbits. Infrared thermal imaging, postoperative MRI, and pathological presentation were obtained and analyzed.

Analysis of imaging-guided thermal ablation puncture routes for tumors of the hepatic caudate lobe.

Aims: The goal of this study was to analyze the puncture routes of imaging-guided thermal ablation for tumors of the hepatic caudate lobe.

Materials And Methods: The imaging-guided thermal ablation puncture routes of 12 cases of hepatic caudate lobe tumors were collected in our hospital from January 2013 to February 2019. The puncture routes were retrospectively analyzed, and the experience of thermal ablation therapy for hepatic caudate lobe tumors was summarized.

Application of the transosseous approach for computed tomography-guided radioactive 125-iodine seed implantation for the treatment of thoracic and abdominal lymph node metastases.

Aim: This study aimed to investigate the technical procedure, safety, and clinical value of the transosseous approach for computed tomography (CT)-guided radioactive 125-iodine (I) seed implantation for the treatment of thoracic and abdominal lymph node metastases.

Subjects And Methods: This was a retrospective study that Nine lymph node metastases in nine patients were treated in our hospital between January 2010 and August 2018. Under CT guidance, at least one puncture path was made through the transosseous approach.

Evaluating the effectiveness of computed tomography-guided I seed interstitial implantation in patients with secondary adrenal carcinoma.

Aim: This study aimed to evaluate the feasibility, safety, and clinical efficacy of computed tomography (CT)-guided I seed interstitial implantation in patients with secondary adrenal carcinoma.

Materials And Methods: Twenty patients with secondary adrenal carcinoma received CT-guided I seed interstitial implantation. A three-dimensional treatment planning system was used to calculate the dose distribution before I seed interstitial implantation.

New secondary metabolite with cytotoxicity from spawning soft coral in Taiwan.

We have conducted a long-term research on the Taiwanese soft coral , which resulted in many xenicane-type diterpenoids such as asterolaurins A-M from coral tissues during the non-spawning period were isolated. Here, we report a new xenicane diterpenoid, asterolaurin N (), along with three known xenicane-type monocarbocyclic diterpenes [13-epi-9-desacetylxenicin (), xeniolide-B 9-acetate () and asterolaurin I ()] from during the spawning period. The structures of the new secondary metabolite were established with an extensive spectroscopic analysis.

Radiation of members of the complex (Asteraceae) on the Qinghai-Tibetan Plateau and their proposed taxonomic treatment.

The existence of intermediate types is a major obstacle that can hinder the circumscription of species. Elucidating the mechanism responsible for intermediate types is essential for achieving a reasonable taxonomical treatment. In this study, we explored the evolutionary history and taxonomic treatment of the (C.

Expert consensus on image-guided radiofrequency ablation of pulmonary tumors: 2018 edition.

Lung cancer ranks first in incidence and mortality in China. Surgery is the primary method to cure cancer, but only 20-30% of patients are eligible for curative resection. In recent years, in addition to surgery, other local therapies have been developed for patients with numerous localized primary and metastatic pulmonary tumors, including stereotactic body radiation therapy and thermal ablative therapies through percutaneously inserted applicators.

Clinical efficacy of endovascular radiofrequency ablation in the treatment of portal vein tumor thrombus of primary hepatocellular carcinoma.

Objective: The objective of this study is to investigate the clinical efficacy and safety of Habib™ VesOpen, a new intravascular radiofrequency ablation (RFA) catheter in percutaneous puncture of portal vein tumor thrombus (PVTT) in patients with primary hepatocellular carcinoma.

Materials And Methods: Collected data of patients with primary hepatocellular carcinoma with portal vein trunk or main branch who were treated by the RFA of portal vein tumor ablation with Habib™ VesOpen, a new intravascular RFA catheter. The postoperative success rate, complications, liver and kidney function, alpha-fetoprotein (AFP), portal vein patency, and tumor thrombus were analyzed, and the survival status of patients was analyzed by Kaplan-Meier survival analysis, and the COX proportional hazards regression model was used to analyze the factors influencing the clinical prognosis of patients.

Magnetic resonance imaging evaluation after radiofrequency ablation for malignant lung tumors.

Objective: The objective of this study was to investigate magnetic resonance imaging (MRI) assessment of the therapeutic response in small lung malignancies (<3 cm) immediately after radiofrequency ablation (RFA).

Materials And Methods: This is a retrospective analysis of MRI performance in 24 cases of small lung tumors (16 primary, 8 metastatic; 20 patients) immediately, post-RFA, and at follow-up. Variables measured included maximum diameters of tumors on pre-RFA MRI, central areas of low signal intensity (SI) on post-RFA T2-weighted images (T2WIs), and central areas of high SI on post-RFA T1WIs.

Effect of heat sink on the recurrence of small malignant hepatic tumors after radiofrequency ablation.

Aims: The aim of this study was to investigate the effect of heat sink on the recurrence of hepatic malignant tumors <3 cm after percutaneous radiofrequency ablation (RFA).

Subjects And Methods: This study included 564 hepatic malignant tumors <3 cm in 381 patients. Preoperative images were used to determine whether these tumors were adjacent to vessels, and the diameter of adjacent vessels was measured.

Treatment of recurrent mediastinal lymph node metastasis using CT-guided nontranspulmonary puncture interstitial implantation of (125)I seeds: Evaluation of initial effect and operative techniques.

Purpose: To evaluate the initial effects and operative techniques for treating recurrent mediastinal lymph node metastasis using CT-guided nontranspulmonary puncture interstitial implantation of (125)I seeds.

Methods And Materials: Thirteen patients (eight men and five women) with a total of 14 recurrent mediastinal lymph node metastatic lesions underwent CT-guided nontranspulmonary puncture interstitial implantation of (125)I seeds.

Results: We used the transpleural cavity approach for six cases (air injection of 200-600 mL), the transsternal approach for three cases, the supersternal approach for one case, and the parasternal/paraspinal approach for the remaining cases (including two cases using the salinoma window technique).

Chinese expert consensus workshop report: Guidelines for thermal ablation of primary and metastatic lung tumors.

Although surgical resection is the primary means of curing both primary and metastatic lung cancers, about 80% of lung cancers cannot be removed by surgery. As most patients with unresectable lung cancer receive only limited benefits from traditional radiotherapy and chemotherapy, many new local treatment methods have emerged, including local ablation therapy. The Minimally Invasive and Comprehensive Treatment of Lung Cancer Branch, Professional Committee of Minimally Invasive Treatment of Cancer of the Chinese Anti-Cancer Association has organized multidisciplinary experts to develop guidelines for this treatment modality.

Local curative effect of MRI-guided radiofrequency ablation on small hepatocellular carcinoma.

Radiofrequency ablation (RFA) is one of the treatment modes for liver cancer. The trauma caused by RFA is small, and its local curative effect is reliable. Computed tomography (CT) can only be used for axial scans, and parts of the lesion are unclear on plain scans.

Treatment of hepatocellular carcinoma adjacent to large blood vessels using 1.5T MRI-guided percutaneous radiofrequency ablation combined with iodine-125 radioactive seed implantation.

Objective: The objective is to study the technology associated with and feasibility of the treatment of hepatocellular carcinoma (HCC) adjacent to large blood vessels using 1.5 T MRI-guided radiofrequency ablation combined with iodine-125 (I-125) radioactive seed implantation.

Methods: Sixteen patients with a total of 24 HCC lesions (average maximum diameter: 2.

1.5T conventional MR-guided iodine-125 interstitial implants for hepatocellular carcinoma: feasibility and preliminary clinical experience.

Purpose: To evaluate the feasibility and therapeutic efficacy of 1.5 T conventional MR-guided percutaneous interstitial implantation of I-125 radioactive seeds in patients with hepatocellular carcinoma (HCC).

Materials And Methods: The institutional ethics committee approved this study.

Artificial pneumothorax with position adjustment for computed tomography-guided percutaneous core biopsy of mediastinum lesions.

Purpose: This study was designed to assess the use of artificial pneumothorax with position adjustment to gain a pleural space approach in computed tomographic-guided core biopsy of mediastinal masses.

Description: Eleven patients with mediastinal lesions who were undergoing percutaneous core biopsies received an artificial pneumothorax with a 22-gauge lumbar puncture needle. Each patient's position was adjusted to place the lesion as high as possible in the thoracic cavity.