Up-Regulated Expression of Matrix Metalloproteinases in Endothelial Cells Mediates Platelet Microvesicle-Induced Angiogenesis.

Background/aims: Platelet microvesicles (PMVs) contribute to angiogenesis and vasculogenesis, but the mechanisms underlying these contributions have not been fully elucidated. In the present study, we investigated whether PMVs regulate the angiogenic properties of endothelial cells (ECs) via mechanisms extending beyond the transport of angiogenic regulators from platelets.

Methods: In vitro Matrigel tube formation assay and in vivo Matrigel plug assay were used to evaluate the pro-angiogenic activity of PMVs.

NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchial epithelial cells.

With application of nano-sized nickel-containing particles (Nano-Ni) expanding, the health concerns about their adverse effects on the pulmonary system are increasing. However, the mechanisms for the pulmonary toxicity of these materials remain unclear. In the present study, we focused on the impacts of NiO nanoparticles (NiONPs) on sirtuin1 (SIRT1), a NAD-dependent deacetylase, and investigated whether SIRT1 was involved in NiONPs-induced apoptosis.

[Study of fluoride released from fluoride-releasing adhesives].

Objective: To study the fluoride release ability of two kinds of fluoride-releasing composite resin adhesives made in China.

Methods: Test samples of fluoride-releasing composite resin adhesives I and II were prepared, and fluoride ion concentrations were measured with a No.720 fluoride ion-sensitive electrode.