[Research Progress for the Toxic Effects of Microplastics on Soil Animals and Plants].

Terrestrial ecosystems represent the most direct and principal reservoirs of plastic contamination on Earth. The toxic effects of microplastic exposure on terrestrial plants have been analyzed from the perspectives of direct toxicity, indirect toxicity, and combined toxicity with other pollutants. By investigating the impacts on the growth, behavior, and oxidative stress responses of soil animals, the toxicological patterns of microplastics have been elucidated.

Impact of metabolic disorders on gallstone disease and perioperative recovery after laparoscopic cholecystectomy.

Background: Gallstone disease (GSD), nonalcoholic fatty liver disease (NAFLD), metabolic dysfunction-associated fatty liver disease (MAFLD), and metabolic syndrome (MetS) are common medical disorders worldwide. This study aimed to ascertain how NAFLD, MAFLD, MetS, and other factors affect the development of GSD, and how the GSD-associated factors influence patient recovery after laparoscopic cholecystectomy (LC).

Methods: We included 200 patients who were diagnosed with GSD and underwent LC between January 2017 and February 2022.

Ecotoxicity stress and bioaccumulation in Eisenia fetida earthworms exposed to vanadium pentoxide in soil.

As an important commercial form of vanadium, vanadium pentoxide (VO) is widely used in various modern industries, and its environmental impacts and ecotoxicity have been extensively studied. In this research, the ecotoxicity of VO to earthworms (Eisenia fetida) in soil was tested by exposure to VO at a series of doses, and biochemical response indices, such as the superoxide dismutase (SOD) and catalase (CAT) enzyme activity and malondialdehyde (MDA) content, were analysed to determine the mechanism by which antioxidant enzymes respond to VO exposure. The bioaccumulation factor (BAF) of vanadium pentoxide in the earthworms and soil was also measured to explore the bioaccumulation process of VO in the test period.

[Effect Factors and Model Prediction of Soil Heavy Metal Bioaccessibility].

The soil environmental pollution situation has been severe in recent years, but studies on evaluating with bioavailability testing and prediction models are lacking, which makes it difficult to accurately assess the ecological risks of contaminated soil. As an important indicator of bioavailability, the bioaccessibility of cadmium (Cd), arsenic (As), copper (Cu), zinc (Zn), and lead (Pb) in the soil was analyzed in this study. The bioaccessibility content and their corresponding soil property data were screened and systematically analyzed to explore the relationship between bioaccessibility content and soil properties.

miR-223-3p regulating the occurrence and development of liver cancer cells by targeting FAT1 gene.

To explore the mechanism of miR-223-3p regulating the occurrence and development of liver cancer cells by targeting FAT1 gene. Bioinformatics analysis was used to analyze the differentially expressed genes in liver cancer tissue chips. Forty-eight cases of liver cancer tissues and corresponding adjacent tissues were selected, and qRT-PCR was used to detect the expression of miR-223-3p and FAT1mRNA in tissues.

[Distribution and Risk Assessment of Polycyclic Aromatic Hydrocarbons in Water Bodies in Seven Basins of China].

The concentrations and spatial distribution characteristics of 16 US EPA priority Polycyclic Aromatic Hydrocarbons (PAHs) in water bodies in seven basins in China were systematically analyzed and summarized. The acute ecological risks of 8 PAHs to aquatic organisms were evaluated by means of species sensitivity distribution (SSD). The joint acute ecological risks of ΣPAH to aquatic organisms were evaluated by concentration addition model and response addition model.

Aldehyde dehydrogenase 1 (ALDH1) isoform expression and potential clinical implications in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is one of the most prevalent and life-threatening malignancies worldwide. There are few diagnostic and prognostic biomarkers and druggable targets for HCC. Aldehyde dehydrogenase 1 (ALDH1) is a marker of stem cells in a variety of cancers, but the mRNA levels and prognostic value of ALDH1 isoforms in HCC patients remain unknown.

[Difference of Species Sensitivities for Aquatic Life Criteria in China and the USA].

Recently, China has commenced water quality criteria (WQC) research using the species sensitivity distribution (SSD) method. However, it is difficult to obtain sufficient toxicity data on native species for thousands of contaminants. In this study, the feasibility of deriving aquatic life criteria using toxicity data from non-native species was analyzed (taking the USA as an example).

[Concentrations and Distribution of Metals in the Core Sediments from Estuary and City Section of Liaohe River].

The particle size, total organic carbon (TOC), total nitrogen (TN), C/N ratio and metal concentrations as well as activities of 210Pb were determined in Liaohe River estuary area (LN-2) and Shenyang area (LN-5), and the organic matter resources were discussed in two core sediments. Also the index of geoaccumulation (Igeo) and enrichment factors (EFs) methods were applied to evaluate the state of heavy metal contamination in the studied sties. The study showed that both sediment cores LN-2 and LN-5 were dominated by silts, and the vertical variations of grain-size composition and organic matter were well distributed in LN- 2 while fluctuated in LN-5.

[Measured and Predicted Aquatic Life Criteria and Risk Assessment of Chromium (VI) in Liaohe River].

In this study, toxicity data of aquatic species in Liaohe River for heavy metal chromium (VI) was collected and selected. The aquatic life criteria for chromium (VI) in Liaohe River was derived based on these toxicity data. Moreover, water samples of 25 sites in Liaohe River were collected, and the concentrations of chromium (VI) in these samples were analyzed.

PNPLA3 I148M variant affects non-alcoholic fatty liver disease in liver transplant recipients.

De novo non-alcoholic fatty liver disease (NAFLD) is a common late complication for long-term survivors after liver transplantation. Genomic studies confirmed that PNPLA3 I148M and TM6SF2 E167K polymorphisms affected NAFLD susceptibility in the general population. However, this association was not validated in survivors after liver transplantation (LT).

Development of water quality criteria for phenanthrene and comparison of the sensitivity between native and non-native species.

Phenanthrene (PHE) is a priority polycyclic aromatic hydrocarbon (PAH) which is toxic to aquatic organisms.However, there has been no paper dealing with water quality criteria (WQC) of PHE due to the shortage of toxicity data of different taxonomic levels. In the present study, toxicity data were obtained from 8 acute toxicity tests and 3 chronic toxicity tests using 8 Chinese native aquatic species from different taxonomic levels, and the water quality criteria was derived using 3 methods.

[Ecotoxicological effect and soil environmental criteria of the heavy metal chromium(VI)].

Nowadays, systematic studies about water quality criteria are being carried out in China, but studies on soil environmental criteria are comparatively insufficient. In this study, germination and root growth of 8 terrestrial plants (Triticum aestivum, Lactuca sativa, Cucumis sativus, Zea mays, Brassica pekinensis, Glycine max, Allium tuberosum and Solanum lycopersicum) and growth inhibition of 1 terrestrial animal (Achatina fulica) were used to determine the chronic ecotoxicological effects of chromium (VI) using the agricultural moisture soil of Baoding. In addition, with the native toxicity data selected, the HC5 (hazardous concentration for 5% of species) and the ecological protected soil environmental criteria of chromium (VI) in Baoding moisture soil were calculated using the log-normal species sensitivity distribution (SSD) method.

Prediction of the joint toxicity of five organophosphorus pesticides to Daphnia magna.

The individual toxicities of five organophosphorus pesticides (dichlorvos, parathion, methyl parathion, malathion and dimethoate) to Daphnia magna were investigated in 24-h immobilization experiments. Using these toxicity data, their combined toxicities were measured in pesticide mixtures designed using either 'equivalent-effect concentration ratios' or 'uniform-design concentration ratios'. The toxicities of mixtures of similarly or dissimilarly acting toxicants are often predicted from the individual toxicities of the component compounds, using one of two distinct biometric models: concentration addition (CA) or independent action (IA).

[Effects of lead on the growth and reproduction of Eisenia fetida with aged soils].

In this study, effects of Pb (NO3)2 on the growth and reproduction of Eisenia fetida were investigated with artificial soils. The results showed that: compared with the control group, the growth of E. fetida in contaminated soil was inhibited significantly with increasing Pb (NO3)2 concentrations.

[Species sensitivity evaluation of Pseudorasbora parva].

Acute toxic effects of cadmium and copper to Pseudorasbora parva and copper to Daphnia magna were tested in this study. Then comparative analysis of species sensitivity of P. parva to six typical pollutants was performed with toxicity data from our experiments and published literatures.

Development of aquatic life criteria for triclosan and comparison of the sensitivity between native and non-native species.

Triclosan (TCS) is an antimicrobial agent which is used as a broad-spectrum bacteriostatic and found in personal care products, and due to this it is widely spread in the aquatic environment. However, there is no paper dealing with the aquatic life criteria of TCS, mainly result from the shortage of toxicity data of different taxonomic levels. In the present study, toxicity data were obtained from 9 acute toxicity tests and 3 chronic toxicity tests using 9 Chinese native aquatic species from different taxonomic levels, and the aquatic life criteria was derived using 3 methods.

Toxicological responses of earthworm (Eisenia fetida) exposed to metal-contaminated soils.

The aim of this study was to evaluate the toxicological responses of earthworm (Eisenia fetida) induced by field-contaminated, metal-polluted soils. Biochemical responses and DNA damage of earthworm exposed to two multi-metal-contaminated soils in a steel industry park and a natural reference soil in Zijin Mountain for 2, 7, 14, and 28 days were studied. Results showed that three enzyme activities, including superoxide dismutase (SOD), acetylcholinesterase (AChE), and cellulase, in earthworm in metal-contaminated soils were significantly different from those of the reference soil.

[Spatial distribution and risk assessment of polycyclic aromatic hydrocarbons in partial surface sediments of Liaohe River].

Nineteen surface sediment samples were collected from Liaohe River and analysed for polycyclic aromatic hydrocarbons (PAHs) with GC-MS. The concentrations of 15 detected PAH compounds ranged from 123.5 to 21 233.

Assessing the anti-estrogenic activity of sodium pentachlorophenol in primary cultures of juvenile goldfish (Carassius auratus) hepatocytes using vitellogenin as a biomarker.

Both pentachlorophenol and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) had been studied widely because of their probable anti-estrogenic activity. Sodium pentachlorophenol (PCP-Na), as a industrial product used in many fields, usually contains a trace of TCDD. The aim of this study was to assess the anti-estrogenic effect of PCP-Na in juvenile goldfish (Carassius auratus) hepatocyte cultures using vitellogenin (VTG) as the biomarker.