Publications by authors named "Zheng-Qing Wang"
Article Synopsis
- Echinococcosis is widespread in Western and Northern China, particularly in Yunnan Province, where cases were documented in epidemiological surveys conducted in 2012 and 2016.
- The study aimed to assess the spatial distribution and characteristics of echinococcosis cases in Yunnan, collected through reports from hospitals and disease control centers between 2021-2022.
- Findings revealed 397 analyzed cases across 89 counties in Yunnan, with the highest incidences in Dali, Diqing, and Kunming, highlighting significant regional differences and a low overall case reporting rate.
DICER1-associated sarcoma of the aortic arch - a case report and literature review.
Cardiovasc Pathol
September 2022
Primary sarcoma of the aorta is extremely rare. We herein report a case of DICER1-associated sarcoma originating from the aortic arch. A 45-year-old male was admitted to the hospital with a cold left hand and a weakened radial artery pulse on the left side.
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- - The study investigates the effects of fasudil, a RhoA/Rho-kinase inhibitor, on relieving arterial spasms in the internal thoracic artery (ITA) during coronary bypass surgery, which happens in about 0.43% of patients.
- - Researchers tested the effectiveness of fasudil alone and in combination with nitroglycerin on ITA samples from 68 patients, finding that the combination led to faster and more sustained relaxation of artery contractions compared to using each drug separately.
- - Results showed that fasudil not only relaxed arterial contractions but also reduced ROCK2 protein levels, suggesting that a mixture of fasudil and nitroglycerin could be a promising new treatment to prevent spasms
The long-term patency rate of saphenous vein (SV) grafts is poor compared to arterial grafts. To investigate the effects of surgical preparation (distention) of SV on hydrogen sulfide (HS) released from the endothelium, human SV segments were harvested from 43 patients during coronary artery bypass surgery (CABG). Acetylcholine (ACh) induced relaxation that was inhibited by N-nitro-L-arginine + indomethacin and cysteine aminotransferase inhibitor aminooxyacetic acid in the normal SV.
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- The study aims to explore how hydrogen sulfide (HS) affects the internal mammary arteries (IMA) and its relationship with specific enzymes like endothelial nitric oxide synthase (eNOS) and phosphodiesterase (PDE)5A.
- Researchers conducted experiments using IMA samples from patients undergoing coronary artery bypass grafting (CABG) to assess their relaxation responses to acetylcholine and a HS donor, NaHS, along with examining the distribution of certain enzymes involved in HS production.
- Results indicated that HS plays a significant role in endothelial function by promoting eNOS phosphorylation and inhibiting PDE5A activity, suggesting potential new treatment approaches for vascular complications in CABG surgeries.
Homocysteine (Hcy) is an independent risk factor for endothelial dysfunction in cardiovascular diseases. We hypothesized that the eNOS transcription enhancer AVE3085 may protect the endothelial function damaged by Hcy in the human internal mammary artery (IMA). Cumulative concentration-relaxation curves to acetylcholine (-10 to -4.
View Article and Find Full Text PDFObjective: Chronic inflammation of the arteries is a critical mechanism responsible for coronary atherosclerosis. We aimed to determine if tumor necrosis factor (TNF)-like cytokine 1A (TL1A) and decoy receptor 3 (DcR3) were involved in promoting atherosclerosis.
Methods: We compared plasma levels of TL1A and DcR3 in patients with coronary artery disease (CAD) undergoing coronary artery bypass grafting (n=40) and patients without CAD group (n=37, normal coronary artery angiogram) by enzyme-linked immunosorbent assay.
Background: Graft spasm remains challenging in coronary artery bypass grafting (CABG). Calcium antagonists are commonly used in patients with coronary artery disease. This study investigated the inhibitory effect of third-generation dihydropyridine calcium channel antagonist benidipine on the vasoconstriction induced by various vasoconstrictors in the human internal mammary artery (IMA).
View Article and Find Full Text PDFObjectives: The strategies of repair of tetralogy of Fallot change with the age of patients. In children older than 4 years and adults, the optimal strategy may be to use different method of reconstruction of the right ventricular outflow tract from those followed in younger children, so as to avoid, or reduce, the pulmonary insufficiency that is increasingly known to compromise right ventricular function.
Methods: From April, 2001, through May, 2008, we undertook complete repair in 312 patients, 180 male and 132 female, with a mean age of 11.