Publications by authors named "Zheng-Jun Wen"
Article Synopsis
- The coarse aggregate-mortar interface transition zone (ITZ) significantly affects concrete's mechanical properties, but studying it is challenging due to mesoscale limitations.
- A series of axial compression tests were performed using the discrete element method (DEM) to analyze the ITZ's impact on concrete specimens, focusing on four phases: coarse aggregates, mortars, ITZ, and voids.
- Results indicated that higher ITZ strength leads to increased compressive strength in concrete, fewer cracks, reduced anisotropy of contact orientation, and a variation in crack development and damage modes in compressed specimens.
This study aimed to develop an effective risk predictor for patients with stage II and III colorectal cancer (CRC). The prognostic value of p-mTOR (Ser2448) levels was analyzed using Kaplan-Meier survival analysis and Cox regression analysis. The levels of p-mTOR were increased in CRC specimens and significantly correlated with poor prognosis in patients with stage II and III CRC.
View Article and Find Full Text PDFObjective: To investigate the role and underlying mechanisms of store-operated Ca(2+) entry (SOCE) in mediating the promoting effect of transforming growth factor (TGF)-β1 on the proliferation of airway smooth muscle cells (ASMCs).
Methods: Rat bronchial smooth muscle cells were cultured as we described previously. The intracellular Ca(2+) concentration ([Ca(2+)]i) of ASMCs was measured by laser confocal microscope Ca(2+) fluorescence imaging with Fluo-3/AM.
Th2 cytokine interleukin (IL)-13 plays a central role in the pathogenesis of allergic asthma. IL-13 exhibits a direct effect on airway smooth muscle cells (ASMCs) to cause airway hyperresponsiveness. IL-13 has been demonstrated to regulate Ca(2+) signaling in ASMCs, but the underlying mechanisms are not fully understood.
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