Cytarabine-Resistant -ITD Leukemia Cells are Associated with Mutation and Multiple Pathway Alterations-Possible Therapeutic Efficacy of Cabozantinib.

Internal tandem duplication of FLT3 juxtamembrane domain (FLT3-ITD)-positive acute myeloid leukemia (AML) leads to poor clinical outcomes after chemotherapy. We aimed to establish a cytarabine-resistant line from -ITD-positive MV4-11 (MV4-11-P) cells and examine the development of resistance. The -ITD mutation was retained in MV4-11-R; however, the protein was underglycosylated and less phosphorylated in these cells.