Publications by authors named "Zheng-Feng Fang"

Article Synopsis
  • Silymarin is a plant extract with various health benefits, including supporting liver function and possibly enhancing milk production in sows.
  • In a study, sows were given silymarin during lactation, resulting in their piglets gaining weight faster and having higher weaning weights compared to those from control sows.
  • Sows consuming silymarin also showed improved serum health markers and increased milk quality, suggesting that this supplement positively affects both their health and the growth of their piglets.
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  • A study on sows showed that offspring from mothers with a low-energy diet had significantly fewer key testicular cells compared to those from well-nourished mothers, indicating that maternal energy intake affects testicular development.
  • The offspring of the low-energy group displayed a higher percentage of cell death, which hints at unhealthy testicular growth potentially influenced by reduced maternal nutrition.
  • Analysis highlighted important signaling pathways (like AMPK-PI3K-mTOR and MAPK) involved in regulating testicular development, suggesting that early life stages are crucial for the impact of maternal energy on this process.
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  • - The study investigated the role of microRNA (miRNA) in early testicular development by analyzing small RNA libraries from boar testes at different ages, utilizing deep sequencing technology to capture over 12 million reads.
  • - Out of 263 known miRNAs, 159 were found in all libraries, with miR-10b being the most abundant, while seven specific miRNAs were identified as significant in testis development across various age groups.
  • - The research highlighted that these miRNAs influence testicular cell growth and death through specific signaling pathways, and offers a comprehensive miRNA profile for understanding testicular development in young boars.
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  • Maternal nutrition, specifically energy intake, significantly impacts fetal growth, with a pig model used to explore this connection through placental protein analysis.
  • The study found that fetuses in the normal-energy diet group showed more variation in weight and glucose levels compared to the more consistent weights of those on a high-energy diet.
  • Key differences in protein expression related to lipid and energy metabolism were identified, suggesting that maternal nutrition influences fetal weight by modifying placental functions.
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The aim of this study was to evaluate the effects of dietary supplementation with amino acids on sperm quality and fertility rates after insemination with boar semen. Twelve Yorkshire boars were paired by age and allocated to one of two dietary treatments composed of total lysine levels of 0.64% (T1) and 0.

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Background: N-3 and N-6 polyunsaturated fatty acids are widely used in reproduction, yet few studies have addressed the effects of dietary n-6/n-3 ratios on boar reproduction. The present study aimed to determine the effects of different dietary n-6/n-3 ratios on the reproductive performance of breeding boars. Thirty-two boars with body weights of 15.

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  • The study aimed to analyze how different amino acid patterns affect boar semen quality when fed low-protein diets.
  • Twenty-four boars were split into four groups receiving varying levels of protein and specific amino acid ratios, with group LP3 showing the best sperm motility and quality.
  • Results indicated that a 13% crude protein diet with a specific Lys:Thr:Trp:Arg ratio of 100:76:38:120 (from LP3) yielded similar or improved reproductive outcomes compared to a higher 17% crude protein diet.
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The present study assessed the effect of birthweight on reproductive performance, including a possible mechanism, in male pigs. Ten newborn male piglets, including five normal birthweight (NBW) piglets and five intra-uterine growth restricted (IUGR) piglets, were used in the study. All piglets were weaned on Day 28 and fed the same diet during the experiment (10 months).

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In this study, we evaluated the effect of replacing dietary fiber with sodium butyrate on reproductive performance and antioxidant defense in a high fat diet during pregnancy by using a rat model. Eighty virgin female Sprague Dawley rats were fed one of four diets--(1) control diet (C group), (2) high fat + high fiber diet (HF group), (3) high-fat +5% sodium butyrate diet (SB group), and (4) HF diet + α-cyano-4-hydroxy cinnamic acid (CHC group)--intraperitoneally on days 8, 10, 12, 14, and 16 of gestation. SB and dietary fiber had similar effects on improving fetal number and reducing the abortion rate; however, the anti-oxidant capacity of maternal serum, placenta, and fetus was superior in the HF group than in the SB group.

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Background: Beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on the reproduction of male animals are widely described in the literature. However, there is little information about the effect of n-3/n-6 PUFA ratios on male health and reproduction. The aim of this study was to investigate the effects of diets with different n-3/n-6 PUFA ratios on the reproductive performance of male rats.

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Objective: The objectives of this study were to investigate the effects of maternal dietary energy types on the mRNA expressions of the placental nutrient transporter and intrauterine fetal growth and to examine whether altered intrauterine fetal growth could be associated with different gene expressions relating to fetal energy metabolism and DNA methylation.

Methods: Seventy-two 3-mo-old rats were allocated to one of four groups: low fat/low fiber (L-L), low fat/high fiber, high fat/low fiber (H-L), or high fat/high fiber. Rats were fed the treatment diets 4 wk before mating and continued in pregnancy until sample collections were obtained on days 13.

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The objective of the present study was to investigate the effects of the addition of fibre and the antioxidant N-acetylcysteine (NAC) to fat-rich diets on fetal intrauterine development in rats. A total of eighty virgin female Sprague-Dawley rats were fed a control diet, a high-fat diet (HF), a high-fat and high-fibre diet (HFF) or a high-fat NAC diet until day 19·5 of gestation. Maternal HFF consumption resulted in a significantly higher mean fetal number and placental weight than in the other groups (P < 0·05).

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Background: There is mounting evidence that an imbalance in oxidant/antioxidant activities plays a pivotal role in fetal development.

Aim Of The Study: To determine the effects of maternal intake of fat and fiber on fetal intrauterine development and antioxidant defense systems of rats.

Methods: Virgin female Sprague-Dawley rats were randomly assigned to 4 groups according to diet: the low-fat, low-fiber group (LL); the low-fat, high-fiber group (LH); the high-fat, low-fiber group (HL); and the high-fat, high-fiber group (HH).

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Vitamin A is largely thought to have immune potential for mammal health; however, no conclusive mechanisms exist regarding its role in the pathogen-initiated innate immune response, or in the linkage between the innate and adaptive immune system during sperm formation in the male reproductive tract. Therefore, this study was conducted to evaluate the nutritional protective effect of vitamin A supplementation on reproductive performance and immune function of the male mouse challenged with pseudorabies virus (PRV). Sperm quality, testis toll-like receptors (TLRs) mRNA expression levels, and serum concentration of cytokines and immunoglobulins at 7 or 14 days post-injection were compared between control mice and PRV-challenged mice fed the same diet supplemented with vitamin A at 0, 4000, 10,000, 25,000 and 50,000 IU/kg, respectively.

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Vitamin E supplement and pseudorabies virus (PRV) infection have a reciprocal role in influencing the maternal immune response, a key determinant of the success or failure of pregnancy. However, it remains unknown whether vitamin E supplement provides protection against PRV-induced failure of pregnancy. This study was therefore conducted to investigate the effect of dietary vitamin E level (0, 75, 375, 750 and 1,500 mg/kg) on the reproduction performance, immunity and expression of Toll-like receptors (TLRs) of PRV-challenged mice.

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