A novel multi-layer prediction approach for sweetness evaluation based on systematic machine learning modeling.

Nowadays, computational approaches have drawn more and more attention when exploring the relationship between sweetness and chemical structure instead of traditional experimental tests. In this work, we proposed a novel multi-layer sweetness evaluation system based on machine learning methods. It can be used to evaluate sweet properties of compounds with different chemical spaces and categories, including natural, artificial, carbohydrate, non-carbohydrate, nutritive and non-nutritive ones, suitable for different application scenarios.

[Effects of electroacupuncture "Shuigou" on expression of soluble guanylate cyclase(sGC) and protein kinase G (PKG)in vascular smooth muscle of cerebral artery in rats with cerebral infarction].

Objective: To observe the effect of electroacupuncture (EA) on the expression of soluble guanylate cyclase (sGC), cyclic guanosine phosphate (cGMP) and protein kinase G (PKG) of cerebral vascular smooth muscle in cerebral infarction (CI) rats, so as to study its dynamic regulation mechanism.

Methods: Male Wistar rats were randomly divided into normal control (=10), sham operation (=40), model (=40), and EA (=40) groups, and the latter three groups were further di-vided into 3, 6, 12 and 24 h subgroups (=10 in each subgroup). The CI model was established by occlusion of the middle cerebral artery (MCAO).

[Effects of electroacupuncture on skeletal muscle and blood glucose in rats with diabetic amyotrophy].

Objective: To explore the effects of electroacupuncture (EA) on skeletal muscle and blood glucose in rats with diabetic amyotrophy.

Methods: Among 40 SD rats, 10 rats were randomly selected into the control group and received no treatment. The remaining 30 rats were treated with intraperitoneal injection of streptozotocin (STZ, 60 mg/kg) to establish diabetes mellitus (DM) model, and then the rats were treated with vascular ligation at right posterior limb to establish amyotrophy model.

Knockdown of angiopoietin-like 4 inhibits the development of human gastric cancer.

Human gastric cancer (GC) is the second most common cause of cancer-related deaths worldwide and is one of the most common metastatic cancers. Tumor proliferation, apoptosis, metastasis and invasion are important predictors of the invasiveness of GC and are key factors in cancer-induced death. Angiopoietin-like 4 (ANGPTL4) is a secreted protein that belongs to the angiopoietin (ANGPTL) family and is involved in the regulation of cancer metastasis.

[The epidemiological characteristic of 97,823 cases of pre-hospital medical care in Guangzhou city].

Objective: To investigate the epidemiological information of patients in pre-hospital medical care in Guangzhou city, and to explore the characteristics of the patients.

Methods: The data in the year of 2008 were retrieved from the computer database of Guangzhou Emergency Medical Rescue Command Center.

Results: (1)In a total of 969 410 calls received, the time of distribution was found to be mainly between 16:00 and 18:00 [11.

Changes of the immunological barrier of intestinal mucosa in rats with sepsis.

Background: Sepsis has become the greatest threat to in-patients, with a mortality of over 25%. The dysfunction of gut barrier, especially the immunological barrier, plays an important role in the development of sepsis. This dysfunction occurs after surgery, but the magnitude of change does not differentiate patients with sepsis from those without sepsis.

[Risk stratification and prognostic evaluation of patients with pulmonary thromboembolism].

Objective: To explore the risk stratification and prognostic evaluation of pulmonary thromboembolism (PTE).

Methods: The clinical data of 46 patients suffering from PTE diagnosed by ventilation perfusion scan or spiral CT pulmonary angiography admitted to our hospital from January 2002 to December 2006 were analyzed retrospectively.

Results: The total mortality was 33% (15/46 cases).

[Analysis of acute cerebral arterial thrombosis with multiple organ dysfunction syndrome].

Objective: To investigate the incidence, case fatality and risk factors of acute cerebral arterial thrombosis complicated by multiple organ dysfunction syndrome (MODS).

Methods: A retrospective study was conducted in 830 patients with acute cerebral arterial thrombosis, among whom 89 also developed MODS.

Results: The incidence of MODS in these patients was 10.