Publications by authors named "Zheng-Fang Lin"
Characterization of lymphocyte subsets in peripheral blood cells of children with EV71 infection.
J Microbiol Immunol Infect
October 2020
Article Synopsis
- Enterovirus 71 (EV71) is a key virus responsible for hand, foot, and mouth disease in children, and this study investigates the immune response by analyzing lymphocyte subsets in affected children.
- Researchers examined blood samples from 32 children with EV71 infection and 32 control subjects, using flow cytometry and real-time PCR to assess various T and B cell populations and key transcription factor levels.
- Results showed a significant drop in certain T cell populations (like helper and regulatory T cells) and an increase in specific B cell and Th2/Th17 cells in children with EV71 infection compared to controls, indicating an altered immune response.
Background: Acute respiratory tract infections (ARTIs) are the leading cause of morbidity and death in children < 5 years worldwide. The aim of this study is to analyze the seroprevalence of nine pathogen specific IgMs in children with ARTIs with respect to gender, age, and seasonality in the Guangzhou region.
Methods: Serum samples were collected from 20160 children with ARTIs admitted to the Guangzhou Women and Children's Medical Center between 2011 and 2012.