[Establishment of a modified canine model of acute cardiac insufficiency].

Objective: To establish a canine model of acute cardiac insufficiency (ACI) by coronary artery occlusion and right ventricular pacing.

Methods: Twelve dogs were subjected to rapid ventricular pacing after ligation of the left anterior descending coronary artery (LAD), to induce the cardiac output (CO) to reduce by 25%; and 50%; from the basal level. The arterial pressure (AP), arterial oxygen saturation (SaO(2)), mean right atrial pressure (mRAP), mean pulmonary capillary wedge pressure (mPCWP), and systemic vascular resistance (SVR) were measured in the dogs according to different CO conditions.