Cytochrome P450 2A6 deletion polymorphism and risk of lung cancer: a meta-analysis.

Previous studies concerning the association between cytochrome P450 2A6 (CYP2A6) deletion polymorphism and lung cancer risk provided controversial results. To clarify the precise association, a meta-analysis was performed. The electronic databases PubMed, Chinese Biomedical Database and Chinese National Knowledge Infrastructure Database were searched for case-control studies last updated on June 3, 2012 that investigated CYP2A6 deletion polymorphism and lung cancer risk.

Methylenetetrahydrofolate reductase 677TT genotype might be associated with an increased lung cancer risk in Asians.

Background: The association between methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and lung cancer risk has been studied in various populations with conflicting results. The aim of this study was to assess the association strength by a meta-analysis of published studies.

Methods: We searched PubMed and Chinese Biomedical (CBM) databases for relevant literatures published by July 18, 2012.