Charge photogeneration dynamics in random terpolymer donor-based non-fullerene polymer solar cells.

Random ternary polymerization is a strategy for tuning the energy levels and improving the batch-to-batch reproducibility of polymer semiconductors for the application in polymer solar cells (PSCs). However, the influence of third component incorporation on exciton properties and charge photogeneration processes in terpolymer-based solar cells is still unclear. In this work, time-resolved spectroscopies were employed to study exciton properties and charge photogeneration processes in PSCs based on a series of terpolymers, PM1 and PM2, which have 20% and 50% of thiophene-thiazolothiazole (TTz) building blocks on the PM6 backbone, respectively.

Carrier recombination dynamics in [MAPbCl][CsPbBr] shell-passivated CsPbBr single crystals.

As one of the commonly used methods for surface passivation of semiconductors, a heterostructure method was developed in this work to passivate surface traps of CsPbBr single crystals (SCs), and further, this method was correlated with carrier recombination processes. Herein, carrier recombination processes in bare and [MAPbCl][CsPbBr]-covered CsPbBr SCs were studied using time-resolved spectroscopic techniques, including steady-state and time-resolved photoluminescence (TRPL) spectroscopy and time-resolved microwave photoconductivity (TRMC). By comparing the kinetics of TRPL and TRMC, we concluded that surface hole-trapping process dominates the TRPL kinetics of bare CsPbBr SCs and surface electron-trapping process dominates the slower decay component in TRMC.

Tissue-Adhesive and Antibacterial Hydrogel Promotes MDR Bacteria-Infected Diabetic Wound Healing via Disrupting Bacterial Biofilm, Scavenging ROS and Promoting Angiogenesis.

Effective treatment of diabetic wounds remains challenging because of multidrug-resistant (MDR) bacterial infections, excessive oxidative stress, and impaired angiogenesis. In this study, a tissue-adhesive and antibacterial hydrogel incorporating MXene and deferoxamine (DFO)-loaded microspheres is developed for the treatment of MDR bacteria-infected diabetic wounds. The hydrogel is built based on covalent crosslinking between ε-poly(L-lysine) and o-phthalaldehyde-terminated four-arm poly(ethylene glycol).

Multi-Feature-Filtering-Based Road Curb Extraction from Unordered Point Clouds.

Road curb extraction is a critical component of road environment perception, being essential for calculating road geometry parameters and ensuring the safe navigation of autonomous vehicles. The existing research primarily focuses on extracting curbs from ordered point clouds, which are constrained by their structure of point cloud organization, making it difficult to apply them to unordered point cloud data and making them susceptible to interference from obstacles. To overcome these limitations, a multi-feature-filtering-based method for curb extraction from unordered point clouds is proposed.

Heat stroke: Pathogenesis, diagnosis, and current treatment.

Recently, the incidence of heat-related illnesses has exhibited a steadily upward trend, which is closely associated with several environmental factors such as climate change and air pollution. The progression of heat-related illnesses is a continuous process and can progress to the terminal period when it transforms into heat stroke, the most severe form. Heat stroke is markedly by a core body temperature above 40°C and central nervous system dysfunction.

Technique notes on the management of superior sagittal or transverse sinus during the falcotentorial meningioma surgery: a case report.

Background: Falcotentorial meningiomas (FM) are surgical challenges for protecting sinus, and the technique notes on the management of superior sagittal or transverse sinus are required for good results.

Methods: We improved the technique notes on the management of superior sagittal or transverse sinus in three FM patients with signs of increased intracranial pressure or chronic headache.

Results: All patients underwent surgeries in the prone position, and occipital/sup-occipital/sub-occipital craniotomy was performed.

A low-swelling hydrogel as a multirole sealant for efficient dural defect sealing and prevention of postoperative adhesion.

Dural defects and subsequent complications, including cerebrospinal fluid (CSF) leakage, are common in both spine surgery and neurosurgery, and existing clinical treatments are still unsatisfactory. In this study, a tissue-adhesive and low-swelling hydrogel sealant comprising gelatin and -phthalaldehyde (OPA)-terminated 4-armed poly(ethylene glycol) (4aPEG-OPA) is developed via the OPA/amine condensation reaction. The hydrogel shows an adhesive strength of 79.

Long non-coding RNA MIR17HG impedes FOSL2-mediated transcription activation of HIC1 to maintain a pro-inflammatory phenotype of microglia during intracerebral haemorrhage.

Activation and polarization of microglia play decisive roles in the progression of intracerebral haemorrhage (ICH), and lactate exposure correlates with microglia polarization. This study explores molecules influencing lactate production and microglia phenotype alteration following ICH. A murine model of ICH was induced by intracerebral injection of collagenase.

Injectable, self-healing hydrogel adhesives with firm tissue adhesion and on-demand biodegradation for sutureless wound closure.

Tissue adhesives have garnered extensive interest as alternatives and supplements to sutures, whereas major challenges still remain, including weak tissue adhesion, inadequate biocompatibility, and uncontrolled biodegradation. Here, injectable and biocompatible hydrogel adhesives are developed via catalyst-free phthalaldehyde/amine (hydrazide) cross-linking reaction. The hydrogels demonstrate rapid and firm adhesion to various tissues, and an phthalaldehyde-mediated tissue adhesion mechanism is established.

Injectable antibacterial tissue-adhesive hydrogel based on biocompatible o-phthalaldehyde/amine crosslinking for efficient treatment of infected wounds.

Injectable antibacterial hydrogels have attracted considerable attention in wound management. However, the development of injectable hydrogels with excellent antibacterial activity, good biocompatibility, and strong tissue adhesion remains a challenge. In this study, an antibacterial tissue-adhesive hydrogel was developed based on a catalyst-free o-phthalaldehyde (OPA)/amine reaction by simply mixing OPA-terminated four-arm poly(ethylene glycol) (4aPEG-OPA) and ε-poly-l-lysine (ε-PLL) solutions.

INHBB promotes tumor aggressiveness and stemness of glioblastoma via activating EGFR signaling.

Background: As most common primary tumor in adult's brain, the glioblastoma (GBM) still ends up with poor survival period. Little progress has been made in recent decades in terms of improving prognosis. There's still an urgent need for novel targets and strategies to overcome such malignancy.

MAPK9 is Correlated with a Poor Prognosis and Tumor Progression in Glioma.

Background: Glioma has a high incidence in young and middle-aged adults and a poor prognosis. Because of late diagnosis and uncontrollable recurrence of the primary tumor after failure of existing treatments, glioma patients tend to have a poor prognosis. Recent advances in research have revealed that gliomas exhibit unique genetic features.

[Pathogenesis and staging treatment for non-specific low back pain based on the meridian sinew theory].

Based on the physiological and pathological characteristics of meridian sinew theory, the staging treatment of non-specific low back pain (NLBP) is explored to provide the reference of clinical practice. The twelve meridian sinews of the human body communicate with the bones and joints of the whole body, which governs the movement, body protection and defense, and meridian regulation. Physiologically, the meridian sinew maintains the functions of the lumbar region.

Understanding Use Intention of mHealth Applications Based on the Unified Theory of Acceptance and Use of Technology 2 (UTAUT-2) Model in China.

The COVID-19 pandemic has significantly impacted the healthcare industry, especially public health resources and resource allocation. With the change in people's lifestyles and increased demand for medical and health care in the post-pandemic era, the Internet and home healthcare have rapidly developed. As an essential part of Internet healthcare, mobile health (mHealth) applications help to fundamentally address the lack of medical resources and meet people's healthcare needs.

Chalcogen bond-assisted syn-locked scaffolds: DFT analysis and biological implications of novel tubulin inhibitors.

A series of new tubulin inhibitors containing chalcogen bonds have been discovered. Density functional theory (DFT) analysis of the O-C-C-S torsion profile shows a preference of 0.8 kcal/mol for the syn-conformer over the anti-conformer.

Clinical characteristics and prognosis of patients with glioblastoma: A review of survival analysis of 1674 patients based on SEER database.

Background: To fully understand the clinical features and prognosis of Glioblastoma (GBM), we extracted the data from the Surveillance, Epidemiology, and End Results (SEER) database and performed a series of analyses.

Methods: We retrospectively analyzed the data of 1674 patients with GBM obtained from the SEER database from 1983 to 2015. Kaplan-Meier analysis was performed to calculate the survival rate, and the log-rank test was used to analyze the survival outcomes.

Improved LDTW Algorithm Based on the Alternating Matrix and the Evolutionary Chain Tree.

Dynamic time warping under limited warping path length (LDTW) is a state-of-the-art time series similarity evaluation method. However, it suffers from high space-time complexity, which makes some large-scale series evaluations impossible. In this paper, an alternating matrix with a concise structure is proposed to replace the complex three-dimensional matrix in LDTW and reduce the high complexity.

Mucoadhesive, Antibacterial, and Reductive Nanogels as a Mucolytic Agent for Efficient Nebulized Therapy to Combat Allergic Asthma.

Asthma is an intractable disease involving the infiltration of inflammatory cells and mucus plugging. Despite small molecular mucolytics having the ability to break the disulfide bonds of mucins, offering a potential way to overcome the airflow obstruction and airway infection, these mucolytics have limited therapeutic effects in vivo. Therefore, in this work, arginine-grafted chitosan (CS-Arg) is ionically cross-linked with tris(2-carboxyethyl)phosphine (TCEP) to obtain nanogels as a mucolytic agent.

The Predicted Value of Kidney Injury Molecule-1 (KIM-1) in Healthy People.

Purpose: Recent studies have focused on whether kidney injury molecule-1 (KIM-1) might serve as a marker of acute kidney tubular injury. Our study analyzed the levels of KIM-1 in the healthy population of different ages to explore the correlation between KIM-1 and age. Moreover, we constructed a model to predict kidney age.

The Role of Recreation Specialization and Self-Efficacy on Life Satisfaction: The Mediating Effect of Flow Experience.

Previous studies confirmed that leisure sport participation could contribute to people's life satisfaction. However, little is known about the predictors of life satisfaction in the context of long-distance running. A model was proposed in this study to examine the relationship between recreation specialization, self-efficacy, flow experience, and life satisfaction.

Human Glioma Cells Therapy Using ATRA-Induced Differentiation Method to Promote the Inhibitive Effect of TMZ and CCDP.

The glioma stem cells (GSCs) performed the self-renewal, proliferation, and differentiation characteristics; their drug resistance has become the main reason for glioma clinical treatment failure. All-trans retinoic acid (ATRA) is an important inducer of cell differentiation, applied in the treatment of hematologic diseases and other solid tumors. ATRA is a fat-soluble compound, which can easily go through the blood-brain barrier.