Publications by authors named "Zheng Zeng"

Objective: To investigate the mechanism of Bushen Huoxue decoction (, BSHXD) to treat endometriosis-induced infertility.

Medhods: The main compounds of BSHXD were determined by high performance liquid chromatography-mass spectrometry (HPLC-MS/MS). The effect of BSHXD on Homeobox A10 (HOXA10) and alpha(v)beta(3) (αvβ3) integrin expression of Ishikawa cells, mouse model, and endometriosis-associated infertility women was evaluated by using Western blot analysis, immunohistochemistry and Real-Time quantitative polymerase chain reaction (RT-qPCR).

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Objective: To analyse the effects of titanium implants coated with various antimicrobial peptide (AMP) layers on bacterial growth and early biofilm formation around the implants.

Methods: A novel AMP mixture was constructed using Type I collagen, sulfonated succinimide 4- (N-Maleimidylphenyl) butyrate, and AMPs. Titanium discs treated with chitosan and hyaluronic acid solutions were reacted with the AMP mixture to obtain AMP-coated titanium discs.

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Article Synopsis
  • - This study examines how the expression of the ELO-6 gene affects the aging process and lifespan in genetically identical Caenorhabditis elegans worms, showing that ELO-6 levels decrease with age and vary between individuals.
  • - Higher and more stable ELO-6 expression is linked to increased individual longevity and overall health span, suggesting that interventions that boost ELO-6 could help prolong life.
  • - The research also highlights the role of the gene pqm-1, which influences ELO-6 expression differences among individual worms, thereby affecting both health span and lifespan in mid-aged C. elegans.
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Background: Image guidance is recommended for patients undergoing intensity-modulated radiation therapy (IMRT) for cervical cancer. In this study, we evaluated the feasibility of a weekly image guidance pattern and analyzed the long-term outcomes in a large cohort of patients.

Methods: The study enrolled patients with Stage IB-IVA cervical cancer who received definitive radiotherapy or concurrent chemoradiotherapy.

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  • The study examined cervical spine alignment and muscular function in different types of cervical kyphosis, focusing on parameters like Cobb angle and range of motion.
  • Participants included individuals with either cervical lordosis or degenerative cervical kyphosis, and data on pain levels and neck disability were also collected.
  • Results showed that flexion-relaxation ratios were higher in cervical lordosis and C-type kyphosis compared to R- and S-types, indicating that different kyphosis types affect neck muscle function and correlate with pain and disability scores.*
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Purpose: To investigate whether congenital cervical spinal stenosis (CCSS) affects the outcome of three-level anterior cervical discectomy and fusion (ACDF) in patients with cervical spondylotic myelopathy (CSM).

Methods: One hundred seventeen patients with CSM who underwent three-level ACDF between January 2019 and January 2023 were retrospectively examined. Patients were grouped according to presence of CCSS, which was defined as Pavlov ratio ≤ 0.

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Cervical cancer is one of the most frequent malignant tumors in females. Concurrent chemoradiotherapy is one of the treatment options for cervical cancer. The treatment time of conventional radiotherapy is long.

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Ultrasound (US) is a type of mechanical wave that is capable of transmitting energy through biological tissues. By utilization of various frequencies and intensities, it can elicit specific biological effects. US imaging (USI) technology has been continuously developed with the advantages of safety and the absence of radiation.

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Article Synopsis
  • * A bibliometric analysis, utilizing tools like CiteSpace and VOSviewer, evaluated 1886 papers to assess publication trends, author collaborations, and influential countries, highlighting Japan and the US as leaders.
  • * Future research hotspots identified include risk factor analysis, outcome prediction, and the application of machine learning, providing valuable insights for scholars and potential directions for upcoming studies.
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Background: Patients with Hematological Malignancies (HM) are at a high risk of mortality from Coronavirus disease 2019 (COVID-19). The available antivirals were different between China and other countries. In China, azvudine was obtained for emergency use to treat adult COVID-19 patients with moderate symptoms in July 2022.

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  • EOG-HCI technology is becoming popular in areas like assistive robotics and augmented reality, but accurately classifying eye movements remains a challenge due to limitations in feature extraction.
  • A new approach, the Residual Self-Calibrated Network with Multi-Scale Channel Attention (RSCA), is proposed to improve this feature extraction by using advanced convolution blocks and attention mechanisms to enhance eye movement classification.
  • Testing on various datasets shows that RSCA significantly outperforms existing methods, establishing it as a leading model in the field and offering insights for future EOG-based designs.
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Background: Currently, treatment regimens for visceral leishmaniasis (VL) are limited because of the presence of numerous adverse effects. Nicotinamide, a readily available and cost-effective vitamin, has been widely acknowledged for its safety profile. Several studies have demonstrated the anti-leishmanial effects of nicotinamide in vitro.

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Porous carbon materials are highly desirable for removing benzene due to their low energy for capture and regeneration. Research has demonstrated that narrow microporous volume is crucial for effective adsorption of benzene at ultra-low concentration. Unfortunately, achieving directional increase in the narrow microporous volume in porous carbon remains a challenge.

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  • * Seventeen patients were treated with a reduced safety margin, and evaluations showed minimal changes in rectal volume with an increase in bladder volume during the treatment process.
  • * Results indicated significant improvements in radiation dosimetry, especially for vaginal coverage, with only mild acute side effects, suggesting that daily oART is a safe and effective option for postoperative cancer treatment.
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Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver condition worldwide. Numerous studies conducted recently have demonstrated a connection between the dysbiosis of the development of NAFLD and gut microbiota. Rebuilding a healthy gut ecology has been proposed as a strategy involving the use of probiotics.

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This study aimed to develop and validate a nomogram based on immune checkpoint genes (ICGs) for predicting prognosis and immune checkpoint blockade (ICB) efficacy in lung adenocarcinoma (LUAD) patients. A total of 385 LUAD patients from the TCGA database and 269 LUAD patients in the combined dataset (GSE41272 + GSE50081) were divided into training and validation cohorts, respectively. Three different machine learning algorithms including random forest (RF), least absolute shrinkage and selection operator (LASSO) logistic regression analysis, and support vector machine (SVM) were employed to select the predictive markers from 82 ICGs to construct the prognostic nomogram.

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Sound speed is a critical parameter in ocean acoustic studies, as it determines the propagation and interpretation of recorded sounds. The potential for exploiting oceanic vessel noise as a sound source of opportunity to estimate ocean sound speed profile is investigated. A deep learning-based inversion scheme, relying upon the underwater radiated noise of moving vessels measured by a single hydrophone, is proposed.

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In this study, we developed a tissue-adhesive and long-term antibacterial hydrogel consisting of protamine (PRTM) grafted carboxymethyl chitosan (CMC) (PCMC), catechol groups modified CMC (DCMC), and oxidized hyaluronic acid (OHA), named DCMC-OHA-PCMC. According to the antibacterial experiments, the PCMC-treated groups showed obvious and long-lasting inhibition zones against E. coli (and S.

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We aimed to develop and validate a predictive model for identifying long-term survivors (LTS) among glioblastoma (GB) patients, defined as those with an overall survival (OS) of more than 3 years. A total of 293 GB patients from CGGA and 169 from TCGA database were assigned to training and validation cohort, respectively. The differences in expression of immune checkpoint genes (ICGs) and immune infiltration landscape were compared between LTS and short time survivor (STS) (OS<1.

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Background: Tumor regression and organ movements indicate that a large margin is used to ensure target volume coverage during radiotherapy. This study aimed to quantify inter-fractional movements of the uterus and cervix in patients with cervical cancer undergoing radiotherapy and to evaluate the clinical target volume (CTV) coverage.

Methods: This study analyzed 303 iterative cone beam computed tomography (iCBCT) scans from 15 cervical cancer patients undergoing external beam radiotherapy.

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Epithelial ovarian cancer is among the deadliest gynecological tumors worldwide. Clinical treatment usually consists of surgery and adjuvant chemo- and radiotherapies. Due to the high rate of recurrence and rapid development of drug resistance, the current focus of research is on finding effective natural products with minimal toxic side effects for treating epithelial ovarian tumors.

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Liver occupying lesions can profoundly impact an individual's health and well-being. To assist physicians in the diagnosis and treatment of abnormal areas in the liver, we propose a novel network named SEU-Net by introducing the channel attention mechanism into U-Net for accurate and automatic liver occupying lesion segmentation. We design the Residual U-block with Squeeze-and-Excitation (SE-RSU), which is to add the Squeeze-and-Excitation (SE) attention mechanism at the residual connections of the Residual U-blocks (RSU, the component unit of U-Net).

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Background: Training senior radiation therapists as "adapters" to manage influencers and target editing is critical in daily online adaptive radiotherapy (oART) for cervical cancer. The purpose of this study was to evaluate the accuracy and dosimetric outcomes of automatic contouring and identify the key areas for modification.

Methods: A total of 125 oART fractions from five postoperative cervical cancer patients and 140 oART fractions from five uterine cervical cancer patients treated with daily iCBCT-guided oART were enrolled in this prospective study.

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