Piperlongumine induces ROS accumulation to reverse resistance of 5-FU in human colorectal cancer via targeting TrxR.

Resistance is a major concern for colorectal cancer patients undergoing chemotherapy. Piperlongumine (PL) has been proven to effectively reverse drug resistance in several types of cancers; however, the mechanisms associated with the reversal effect and the targets of PL in cancer drug resistance are still unclear. In this research, the reversal effects and associated mechanisms of PL in 5-Fluorouracil (5-FU) resistance colorectal cancer were investigated both in vitro and in vivo.

Optimized Phase-Generated Carrier Demodulation Algorithm for Membrane-Free Fabry-Pérot Acoustic Sensor with High Sensitivity.

Demodulation of fiber optic Fabry-Pérot (F-P) acoustic sensors with high sensitivity and a large dynamic range continues to pose significant challenges. In this paper, we propose an advanced phase-generated carrier (PGC) demodulation algorithm, applied innovatively to membrane-free F-P acoustic sensors operating under high sound pressure. The algorithm optimizes acoustic demodulation results by adjusting the mixing phase delay, achieving the best signal to noise and distortion ratio (SINAD) and total harmonic distortion (THD) (<1%).

Atractylenolide I ameliorates post-infectious irritable bowel syndrome by inhibiting the polymerase I and transcript release factor and c-Jun N-terminal kinase/inducible nitric oxide synthase pathway.

Objective: To explore the therapeutic effect and target of atractylenolide I (AT-I) on post-infectious irritable bowel syndrome (PI-IBS) rats.

Methods: Therefore, the preliminarily mechanism of AT-I in anti-PI-IBS were first predicted by network pharmacology and molecular docking, then the possible signaling pathways were systematically analyzed. Finally, the potential therapeutic targets and possible signaling pathways of AT-I on PI-IBS in Sprague-Dawley (SD) rat model were verified by experiments.

Volume Bragg grating with tunable reflectivity and the bandwidth assisted Fabry-Pérot cavity.

The rigid Fabry-Pérot (F-P) cavity has emerged as the preferred core sensing component for optical pressure, vibration, and acoustic sensing in harsh environments, owing to its high reliability and structural stability. However, due to the inadequate temperature resistance of the optical dielectric film, maintaining a high level of precision in the rigid F-P cavity at elevated temperatures proves to be challenging. Volume Bragg grating (VBG) is a three-dimensional optical element modified by a femtosecond laser within a transparent glass medium to create a periodic refractive index distribution.

Performance Study of F-P Pressure Sensor Based on Three-Wavelength Demodulation: High-Temperature, High-Pressure, and High-Dynamic Measurements.

F-P (Fabry-Perot) pressure sensors have a wide range of potential applications in high-temperature, high-pressure, and high-dynamic environments. However, existing demodulation methods commonly rely on spectrometers, which limits their application to high-frequency pressure signal acquisition. To solve this problem, this study developed a self-compensated, three-wavelength demodulation system composite with an F-P pressure sensor and a thermocouple to construct a comprehensive sensing system.

A Large-Range and High-Sensitivity Fiber-Optic Fabry-Perot Pressure Sensor Based on a Membrane-Hole-Base Structure.

In the field of in situ measurement of high-temperature pressure, fiber-optic Fabry-Perot pressure sensors have been extensively studied and applied in recent years thanks to their compact size and excellent anti-interference and anti-shock capabilities. However, such sensors have high technological difficulty, limited pressure measurement range, and low sensitivity. This paper proposes a fiber-optic Fabry-Perot pressure sensor based on a membrane-hole-base structure.

Optimized Design of an Ultrasonic-Based High-Efficiency Wireless Passive Monitoring System for Sealed Metal Compartments.

The condition monitoring (CM) of sealed metal compartments (SMCs) is an urgently required restructure. Ultrasound penetrates SMCs to power and communicate with built-in sensors, enabling the CM of SMCs. However, current ultrasonic wireless power transfer and data communication (UWPTADC) systems are large and complex, and limited by the efficiency of energy transfer and data reliability.

Identifying Qingkailing ingredients-dependent mesenchymal-epithelial transition factor-axiation "π" structuring module with angiogenesis and neurogenesis effects.

Objective: To explore the functional role of the drug-dependent mesenchymal-epithelial transition (Met)-axiation "π" structural module of neurogenesis after processing by three components of Qingkailing injection in neurogenesis and angiogenesis in cerebral ischemia.

Methods: We used a Glutathione S-transferase (GST)-pull down assay, isothermal titration calorimetry assay, and other related methods to identify the relationships among Met, inositol polyphosphate phosphatase like 1 (Inppl1), and death associated protein kinase 3 (Dapk3) in this allosteric module. The biological effects of the modules of neurons generation composed of Met, Inppl1, and Dapk3 were measured through Western blot, apoptosis analysis, and double immunofluorescence labeling.

High Performance Rotating Triboelectric Nanogenerator with Coaxial Rolling Charge Pump Strategy.

With the development of society and the advancement of technology, the emergence of the Internet of Things (IoT) has changed people's lifestyles and raised the demand for energy to a new level. However, there are some drawbacks in terms of energy supply for IoT sensors, such as limited battery capacity and limitations in replacement and maintenance. Therefore, it has become urgent to develop a sustainable green energy source (wind energy) using the surrounding environment.

Performance improvement of underwater LIBS qualitative and quantitative analysis by irradiating with long nanosecond pulses.

Long nanosecond pulses have been proven to be efficient at enhancing underwater LIBS emission. However, the quantitative analytical capability of underwater long-pulse LIBS has yet to be further revealed. In this work, we investigated the spectral characteristics by irradiating with a laser pulse of 120 ns duration.

Alternative Approach to Design and Optimization of High-Q Ring Resonators for Membrane-Free Acoustic Sensors.

Membrane-free acoustic sensors based on new principle and structure are becoming a research hotspot, because of many advantages, e.g., their wide bandwidth and high sensitivity.

Enhanced wide-range gas pressure sensing with an all-solid open Fabry-Pérot interferometer.

The sensors with a wide gas pressure detection range are urgently demanded in many industrial applications. Here, we propose a gas pressure sensor based on an all-solid open Fabry-Pérot interferometer, which is prepared by using optical contact bonding to ensure high structural strength and high-quality factor of 8.8 × 10.

Non-alcoholic fatty liver disease combined with rheumatoid arthritis exacerbates liver fibrosis by stimulating co-localization of PTRF and TLR4 in rats.

Rheumatoid arthritis (RA) has a high prevalence in patients with non-alcoholic fatty liver disease (NAFLD); however, the underlying mechanism is unclear. To address this, our study established a rat model with both NAFLD and RA by feeding a high-fat diet (HFD) and administering intradermal injection of Freund's complete adjuvant (FCA) with bovine type II collagen. Collagen-induced RA (CIA) was confirmed by hind paw swelling and histological examination.

Astragalus polysaccharide alleviates alcoholic-induced hepatic fibrosis by inhibiting polymerase I and transcript release factor and the TLR4/JNK/NF-κB/MyD88 pathway.

Ethnopharmacological Relevance: Astragali Radix (AR), the root of Astragalus membranaceus (Fisch.) Bge. or Astragalus membranaceus (Fisch.

Acoustic Sensing Performance Investigation Based on Grooves Etched in the Ring Resonators.

Acoustic detection based on optical technology has moved in the direction of high sensitivity and resolution. In this study, an optical waveguide acoustic sensor based on a ring resonator with the evanescent field is proposed. Grooves are introduced into the ring resonators as a direct sensitive structure to excite the evanescent field.

Triboelectric-Electromagnetic Hybrid Wind-Energy Harvester with a Low Startup Wind Speed in Urban Self-Powered Sensing.

Wind energy as a renewable energy source is easily available and widely distributed in cities. However, current wind-energy harvesters are inadequate at capturing energy from low-speed winds in urban areas, thereby limiting their application in distributed self-powered sensor networks. A triboelectric-electromagnetic hybrid harvester with a low startup wind speed (LSWS-TEH) is proposed that also provides output power within a wide range of wind speeds.

Research on high-temperature characteristics of a miniature Fabry-Pérot cavity acoustic sensor.

The applications of fiber-optic acoustic sensors are expanded to the high-temperature field, but it still faces challenges to realize the wide-band and high-sensitivity acoustic signal detection in high-temperature environments. Here, we propose a miniature membrane-free fiber-optic acoustic sensor based on a rigid Fabry-Pérot (F-P) cavity and construct an acoustic signal detection system. The system can achieve high-sensitivity acoustic detection while maintaining a wide frequency band in temperatures ranging from 20 °C to 200 °C.

Paeoniflorin Ameliorates Colonic Fibrosis in Rats with Postinfectious Irritable Bowel Syndrome by Inhibiting the Leptin/LepRb Pathway.

Postinfectious irritable bowel syndrome (PI-IBS) is a highly prevalent gastrointestinal disorder associated with immune dysregulation and depression- and anxiety-like behaviors. Through traditional medicine, the active ingredient of Paeoniae Radix called paeoniflorin (PF) was previously found to prevent the symptoms of PI-IBS. However, there is limited information on the effects of PF on intestinal function and depression- and anxiety-like symptoms in PI-IBS animal models.

Development of novel nitric oxide-releasing quinolinedione/furoxan hybrids as NQO1 inhibitors for intervention of drug-resistanthepatocellular cancer.

A series of novel nitric oxide (NO)-releasing 5,8-quinolinedione/furoxan hybrids (8a-h and 9a-h) were designed and synthesized through coupling different alkanolamine substituted phenylsulfonyl furoxan with 5,8-quinolinedione. Most compounds displayed high cytotoxic activity against drug-sensitive/-resistant cancer cells. In particular, the IC of 9a (0.

Compact fiber-optic Fabry-Perot cavity based on sandwich structure adopting direct bonding of quartz glass.

A compact fiber-optic Fabry-Perot (F-P) cavity for a sensor is designed based on a sandwich structure, adopting direct bonding of quartz glass. The reflective F-P cavity is manufactured by a fiber optic with a quartz glass ferrule and the sandwich structure with an air cavity, which is achieved by direct bonding of quartz glass. This fabrication process includes plasma surface activation, hydrophilic pre-bonding, high-temperature annealing, and dicing.

An Optimal Design Method for Improving the Efficiency of Ultrasonic Wireless Power Transmission during Communication.

Due to the excellent directivity, strong penetrability, and no electromagnetic shielding effect, ultrasonic waves have good potential for wireless energy transmission and information transfer inside and outside of sealed metal devices. However, traditional ultrasonic based energy transmission methods usually result in considerable energy consumption because of the impedance mismatch during the impedance modulation of the communication. This paper presents an optimal design method for efficient energy transfer during ultrasonic communication.

Acoustic Performance Study of Fiber-Optic Acoustic Sensors Based on Fabry-Pérot Etalons with Different Q Factors.

The ideal development direction of the fiber-optic acoustic sensor (FOAS) is toward broadband, a high sensitivity and a large dynamic range. In order to further promote the acoustic detection potential of the Fabry-Pérot etalon (FPE)-based FOAS, it is of great significance to study the acoustic performance of the FOAS with the quality (Q) factor of FPE as the research objective. This is because the Q factor represents the storage capability and loss characteristic of the FPE.

An Optical Acoustic Detection System Based on Fabry Pérot Etalon Stability Structure.

The optical acoustic detection system based on the Fabry Pérot Etalon (FPE) with high quality-factor (High Q) and stability structure is described and tested. The FPE contains two high-reflectivity Plano-Concave lenses, achieving high fineness and stability. The protective structure of the confocal stabilized FPE is composed of an invar tube, copper sheath, Bakelite sheath and aluminum housing to protect the sensor from the effects of ambient temperature and vibration.

Suppression of PTRF Alleviates Post-Infectious Irritable Bowel Syndrome via Downregulation of the TLR4 Pathway in Rats.

Accumulating evidence suggests that the polymerase I and transcript release factor (PTRF), a key component of the caveolae structure on the plasma membrane, plays a pivotal role in suppressing the progression of colorectal cancers. However, the role of PTRF in the development of functional gastrointestinal (GI) disorders remains unclear. Post-infectious irritable bowel syndrome (PI-IBS) is a common functional GI disorder that occurs after an acute GI infection.

Micro-fiber-optic acoustic sensor based on high-Q resonance effect using Fabry-Pérot etalon.

A micro-fiber-optic acoustic sensor based on the high-quality-factor (high-Q) resonance effect that uses a Fabry-Pérot etalon (FPE) is presented in this study. The device has been demonstrated experimentally to be a high-sensitivity acoustic sensor with a large dynamic range over a wide frequency band. Optical contact technology was used to improve the robustness of the FPE, which consists of two parallel lenses with high reflectivity exceeding 99%.