Publications by authors named "Zheng Wang"

Paeonia suffruticosa is a plant of Paeonia in Paeoniaceae. It is an important woody ornamental flower in the world. High temperature in summer hinders the growth of tree peony and reduces its ornamental quality, which restricts the cultivation and application of tree peony in Jiangnan area of China.

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Background: Liver metastasis (LM) is of vital importance in making treatment-related decisions in patients with colorectal cancer (CRC). The aim of our study was to develop and validate prediction models for LM in CRC by making use of machine learning.

Methods: We selected patients diagnosed with CRC from 2010 to 2015 from the Surveillance, Epidemiology, and End Results (SEER) database.

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Coastal areas of the Arctic and Subarctic are vulnerable to accidental oil spills, impacting the ecosystem, society, and economy. This article provides a comprehensive overview of oil spill pollution issues in cold regions, focusing on environmental impacts, oil transport and fate, coastal/shoreline response measures, and the state of current international policies and regulations. Numerous studies have described the potential effects of oil pollution (crude oil and refined products) on wildlife (invertebrates, fish, birds, and marine mammals) and coastal communities within the Arctic and Subarctic regions.

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Lung cancer is the leading cause of cancer-related deaths globally. Despite recent improvements in incidence and mortality rates, the prognosis of lung cancer remains dire.F-FDG PET/CT plays a vital role in diagnosing, staging, and monitoring the therapeutic efficacy of lung cancer.

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Implantable medical electronic devices (IMEDs) have attracted great attention and shown versatility for solving clinical problems ranging from real-time monitoring of physiological/ pathological states to electrical stimulation therapy and from monitoring brain cell activity to deep brain stimulation. The ongoing challenge is to select appropriate materials in target device configuration for biomedical applications. Currently, silk-based biomaterials have been developed for the design of diagnostic and therapeutic electronic devices due to their excellent properties and abundant active sites in the structure.

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To overcome the problems of the low signal-to-noise ratio and poor performance of wood ultrasonic images caused by ring-down vibrations during the ultrasonic quality detection of wood, a composite pulse excitation technique using a wood air-coupled ultrasonic detection system is proposed. Through a mathematical analysis of the output of the ultrasonic transducer, the conditions necessary for implementing composite pulse excitation were analyzed and established, and its feasibility was verified through COMSOL simulations. Firstly, wood samples with knot and pit defects were used as experimental samples.

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A synergistic Pd/Cu catalyst system has been developed for stereodivergent transformation of Morita-Baylis-Hillman (MBH) carbonates and Schiff bases derived from simple amino acids to afford a series of optically active β-branched γ-methyleneglutamic acid derivatives with adjacent tertiary/tertiary and quaternary/tertiary stereocenters in high yields (up to 96 %) with excellent diastereo- and enantioselectivities (>20/1 dr and >99 % ee in most cases) under mild conditions. The use of SKP ligand is disclosed to be crucial for the success of the transformation, and in particular allowing the reaction to proceed at low catalyst loading (0.02 mol % for Pd and 0.

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Purpose: Studies consistently show abnormally high levels of lactate acid in cardiovascular disease patients, suggested that targeting lactate production may serve as potential strategies for the treatment in the future. However, observational results may be subject to residual confounding and bias.

Methods: This study used the dataset from GWAS database to examine confounding in epidemiologic associations between lactate and cardiovascular diseases.

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The Swine Influenza Virus (SIV) is a major respiratory pathogen in swine, causing acute, febrile, and highly transmissible infections. This virus is widespread globally and poses significant risks to human health and social development. Traditional prevention strategies for SIV rely on the use of inactivated vaccines combined with Alum adjuvants.

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The homogeneous catalytic hydrogenation of benzo-fused heteroarenes generally provides partially hydrogenated products wherein the heteroaryl ring is preferentially reduced, such as quinoline hydrogenation, leading to 1,2,3,4-tetrahydroquinoline. Herein, we report a carbocycle-selective hydrogenation of fused -heteroarenes (quinoline, isoquinoline, quinoxaline, etc.) using the Ru complex of a chiral spiroketal-based diphosphine (SKP) as the catalyst, affording the corresponding 5,6,7,8-tetrahydro products in high chemoselectivities.

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Colorectal cancer (CRC) is one of the most common cancers worldwide. Early detection and removal of colorectal polyps during colonoscopy are crucial for preventing such cancers. With the development of artificial intelligence (AI) technology, it has become possible to detect and localize colorectal polyps in real time during colonoscopy using computer-aided diagnosis (CAD).

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Due to the unavoidable impact of ionizing radiation on the heart located near the mediastinum, varying degrees of myocardial damage may occur. As a result, the clinical application of radiotherapy in cancer treatment is significantly limited. However, the molecular mechanisms underlying radiation-induced heart disease (RIHD) are not yet fully understood, and there is a lack of disease-specific treatment strategies.

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Nanobodies (Nbs) hold great promise as next-generation cancer immunotherapies, but their efficacy is hindered by their poor pharmacokinetics and the inability to trigger Fc-mediated immune killing functions. To address these limitations, we designed and synthesized rhamnolipid-modified Nbs as a type of antibody-recruiting molecule by site-specifically conjugating EGFR-targeting Nb 7D12 to a series of rhamnolipid derivatives, and their biological profiles were evaluated in vitro and in vivo. Investigation of the structure-activity relationship revealed that the number of rhamnose (Rha) units and the length of the PEG linker in the conjugates affected anti-tumor activities.

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Environmental exposure to heavy metals is ubiquitous. However, its relationship with steroid hormone levels is not well understood, particularly in pregnant women. This study investigated the association between prenatal heavy metal exposure and steroid hormone levels in an e-waste disposal area in China.

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Article Synopsis
  • - Various types of artificial water channels have been developed, but creating 1D water channels from small molecules is challenging due to the difficulty in manipulating water molecules.
  • - This study builds on previous research by modifying a nucleoside, 2-amino-2'-fluoro-2'-deoxyadenosine (2FA), to enhance its hydration and self-assembly properties.
  • - One derivative, 2-amino-8-(4-aminophenyl)-2'-deoxy-2'-fluoro-D-adenosine, can form an S-shaped channel in the solid state that incorporates arrays of water wires, offering new possibilities for nucleoside-based water channel materials.
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  • - This study aims to compare the long-term risk of developing type 2 diabetes (T2D) among women who had gestational diabetes mellitus (GDM) versus those with impaired glucose tolerance (IGT).
  • - Analyzing data over 25 years, researchers found that women with GDM, especially older Māori women or those with socioeconomic challenges, had a higher risk of developing T2D compared to those with IGT, with the first five years after childbirth being crucial for prevention.
  • - The research emphasizes the need for early and tailored interventions for women post-GDM, taking into account factors like age, ethnicity, and socioeconomic status to effectively reduce the risk of T2D.
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In order to understand the spatial-temporal distribution and ecological risk of antibiotics in the soil of an agricultural watershed in the Three Gorges Reservoir area, the topsoil samples were collected at 26 sites in the Wangjiagou small watershed, Fuling District, Chongqing in spring, summer, autumn, and winter of 2022, and 21 antibiotics with five classes were determined using solid phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry. The content levels and spatial-temporal distribution of antibiotics were analyzed, the correlations between antibiotic contents and soil physicochemical factors were discussed, and the potential ecological risk of antibiotics in the soil was evaluated using the risk quotient method. The results showed that the detection rates of 21 antibiotics were 0-100% with the range of ND-219.

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Osteoarthritis (OA) is a chronic, degenerative joint disease primarily characterised by damage to the articular cartilage, synovitis and persistent pain, and has become one of the most common diseases worldwide. In OA cartilage, various forms of cell death have been identified, including apoptosis, necroptosis and autophagic cell death. Ever-growing observations indicate that ferroptosis, a newly-discovered iron-dependent form of regulated cell death, is detrimental to OA occurrence and progression.

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Article Synopsis
  • The study highlights that wear debris from joint implants leads to excessive osteoclast activity, causing bone loss and implant failure in total joint surgeries.
  • Researchers developed hollow ruthenium oxide (RuO) nanospheres as an antioxidant to combat this problem by inhibiting processes that promote osteoclast formation and activity.
  • In experiments, these RuO nanospheres successfully reduced bone loss and negative tissue changes in mice exposed to harmful implant materials, suggesting potential for broader therapeutic uses in related inflammatory conditions.
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  • Periodontitis (PD) is a serious gum disease that can lead to tooth loss and other health issues, emphasizing the need for early detection.
  • This study uses a deep learning model called PSPNet along with dental plaque microbial data to create a Periodontitis Risk Score (PRS), aiming to identify individuals at high risk for developing PD.
  • The research found 27 key indicators for PD risk, demonstrating that the PRS can effectively differentiate between healthy individuals and PD patients with high accuracy in just 10 seconds per sample, paving the way for better early screening and preventive care.
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To comprehensively review cardiorenal syndrome (CRS)-related research, this study analyzes its whole landscape and future trends from a bibliometric perspective. Using "cardiorenal syndrome" as the key word, a representative dataset of CRS was constructed in the Web of Science Core Collection (Science Citation Index Expanded) database up to November 2023. VOSviewer (version 1.

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