Research on a New Method of Macro-Micro Platform Linkage Processing for Large-Format Laser Precision Machining.

In recent years, the macro-micro structure (servo platform for macro motion and galvanometer for micro motion) composed of a galvanometer and servo platform has been gradually applied to laser processing in order to address the increasing demand for high-speed, high-precision, and large-format precision machining. The research in this field has evolved from step-and-scan methods to linkage processing methods. Nevertheless, the existing linkage processing methods cannot make full use of the field-of-view (FOV) of the galvanometer.

High-Fidelity, High-Conductivity and Multifunctional PEDOT:PSS Hydrogel for Efficient Electromagnetic Interference Shielding and Ultrafast Response Electrochromic Applications.

Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) hydrogel are promising for applications in electromagnetic interference (EMI) shielding, energy storage, and electrochromic (EC) devices. However, challenges such as low conductivity at reduced solid content, limited charge storage, poor mechanical properties, and structural distortion during solvent treatment limit their high-performance applications. To address these issues, a high-fidelity, high-conductivity and multifunctional PEDOT:PSS hydrogel is developed by an ice crystal-assisted skeleton stacking and stepwise treatment strategy, achieving ultrahigh conductivity of 87,249 S m at 5.

Miniaturized Designs of Implantable and Wireless Hemodynamic Pressure Monitoring Capsules.

Objective: Hemodynamic pressure (HP) monitoring is critical for managing cardiovascular diseases. Clinical Doppler echocardiography and invasive catheter monitoring cannot realize remote continuous monitoring in daily life. Current implantable wireless equipment depends on custom chips or indirect sensing, presenting challenges in cost-effective and precise applications.

Associations of ischemic heart disease with brain glymphatic MRI indices and risk of Alzheimer's disease.

Background: The impact of ischemic heart disease (IHD) on the brain glymphatic MRI indices and risk of Alzheimer's disease (AD) remains largely unclear. This study aimed to investigate the associations between IHD, brain glymphatic MRI indices and risk of AD.

Methods: A total of 1385 non-dementia subjects (55.

SMARCA4 Inhibits Breast Cancer Progression and Metastasis through RHOA Suppression.

Triple-negative breast cancer (TNBC) presents the most challenging subtype of the disease due to its aggressive nature and lack of targeted therapy options. To identify regulators of TNBC, we conducted a genome-wide CRISPR-knockout screen in both 3D tumor spheroid and 2D cell culture models. The 3D spheroid model displayed unique potential in identifying putative tumor suppressors due to its closer mimicry of in vivo tumor growth conditions.

Advances in chemically modified HSA as a multifunctional carrier for transforming cancer therapy regimens.

Human serum albumin (HSA) is a versatile, biodegradable, biocompatible, non-toxic, and non-immunogenic protein nanocarrier, making it an ideal platform for developing advanced drug delivery systems. These properties have garnered significant attention in utilizing HSA nanoparticles for the safe and efficient delivery of chemotherapeutic agents. HSA-based nanoparticles can be surface-modified with various ligands to enable tumor-targeted drug delivery, enhancing therapeutic specificity and efficacy.

The impact of nutrient deficiency on the structure of soil microbial communities within a double-cropping system.

In the North China Plain, it is common for farmers to regularly clear crop residues from their fields. The prevalent practice of fertilization in this region continues to depend heavily on the use of compound fertilizers. Howere , long-term single fertilizer application has become the norm in the present agricultural production, which not only destroys the crop rotation system but also negatively affects the soil environment and crop yields.

Relative bioavailability of selenium yeast, selenomethionine, hydroxyl-selenomethionine and nano-selenium for broilers.

Selenium (Se) is an essential trace element for humans and animals. Development and application of new forms of Se sources with lower toxicity and higher bioavailability has been attracting more attention. However, the bioavailabilities of Se from several new Se sources for broilers remain unclear.

A randomized controlled trial of an intervention for unmet supportive care needs addressing colorectal cancer couples.

Purpose: Supported by the Supportive Care Needs Framework (SCNF), we developed a colorectal cancer (CRC) couple-based unmet supportive care needs (USCNs) intervention program, which has been proven to be feasible. The intention was to assess what the clinical efficacy of this intervention would be in CRC couples.

Methods: One hundred and sixty-eight CRC couples were randomly assigned to one of two groups: a control group (receiving normal care) or an intervention group (receiving normal care plus a five-week USCNs intervention).

Aptamer-Conjugated Exosomes Ameliorate Diabetes-Induced Muscle Atrophy by Enhancing SIRT1/FoxO1/3a-Mediated Mitochondrial Function.

Background: Muscle atrophy is associated with Type 2 diabetes mellitus, which reduces the quality of life and lacks effective treatment strategies. Previously, it was determined that human umbilical cord mesenchymal stromal cell (hucMSC)-derived exosomes (EXOs) ameliorate diabetes-induced muscle atrophy. However, the systemic application of EXOs is less selective for diseased tissues, which reduces their efficacy and safety associated with their nonspecific biological distribution in vivo.

Web-based cognitive interventions on subjective cognitive impairment in cancer survivors: A systemic review.

Objective: Cancer survivors have experienced subjective cognitive impairment (SCI) when they received cancer diagnoses or treatments. Their psychosocial and emotional statuses were also impacted. With the advancement of web technologies, web-based cognitive interventions have been implemented in the management and the alleviation of the SCI, the psychosocial distress, and the emotional distress in cancer survivors.

NKAPL facilitates transcription pause-release and bridges elongation to initiation during meiosis exit.

Transcription elongation, especially RNA polymerase II (Pol II) pause-release, is less studied than transcription initiation in regulating gene expression during meiosis. It is also unclear how transcription elongation interplays with transcription initiation. Here, we show that depletion of NKAPL, a testis-specific protein distantly related to RNA splicing factors, causes male infertility in mice by blocking the meiotic exit and downregulating haploid genes.

Corona electric field triggered N lasing from a femtosecond laser filament in air.

The emission of N lasing at 391 nm from 800 nm femtosecond laser filament in air at 1 atm presents significant challenges due to the quenching effect induced by oxygen molecules. We introduce a simple technique for the 391 nm N lasing emission induced by a corona electric field-assisted femtosecond filament in air. This technique greatly addresses the challenge of exciting a 391 nm lasing from 800 nm femtosecond laser filament in air at 1 atm.

Enzyme-independent functions of HDAC3 in the adult heart.

The cardioprotective effects of histone deacetylase (HDAC) inhibitors (HDIs) are at odds with the deleterious effects of HDAC depletion. Here, we use HDAC3 as a prototype HDAC to address this contradiction. We show that adult-onset cardiac-specific depletion of HDAC3 in mice causes cardiac hypertrophy and contractile dysfunction on a high-fat diet (HFD), excluding developmental disruption as a major reason for the contradiction.

Preoperative comprehensive risk estimation for axillary lymph node metastasis in breast cancer: development and verification of a network-based prediction model.

To prevent the overaggressive treatment of axillary lymph nodes (ALNs) in breast cancer, it is necessary to develop a convenient analysis method that accurately and comprehensively reflects whether ALNs are metastatic or nonmetastatic. We retrospectively analyzed data from patients who underwent surgery for breast cancer at the Weifang Hospital of Traditional Chinese Medicine between January 2019 and June 2023. Binary logistic regression analysis was used to predict the metastasis status of ALNs.

Deep proximal gradient network for absorption coefficient recovery in photoacoustic tomography.

The optical absorption properties of biological tissues in photoacoustic (PA) tomography are typically quantified by inverting acoustic measurements. Conventional approaches to solving the inverse problem of forward optical models often involve iterative optimization. However, these methods are hindered by several challenges, including high computational demands, the need for regularization, and sensitivity to both the accuracy of the forward model and the completeness of the measurement data.

Bioinspired balloon catheter integrated with stretchable "flounder" electrodes under high voltage for uniform pulsed field ablation.

Atrial fibrillation leads to severe diseases such as heart failure and strokes. While catheter ablation is prevalent for the treatment, existing techniques hardly can achieve both tissue selectivity and ablation uniformity. Here, we propose a bioinspired strategy for balloon-based pulsed field ablation (PFA) systems based on "flounder" electrodes.

Probe-type optical fiber sensors for electric field distribution measurement.

This paper reports a compact fiber optical electric field (E-field) sensor aiming for the precise detection of transient E-field distributions. Here, a reflective polarization-reciprocal optical path is proposed, which inherently mitigates the temperature-induced birefringence interference of the electro-optical crystal without the need for additional optical elements, thereby facilitating a reduced-size sensing probe. Furthermore, an adaptive particle swarm optimization (A-PSO) algorithm has been utilized for the first time to optimize the insulation structure of the optical E-field sensor, which significantly suppresses field distortion within the sensing region by 50%.

Viromics-based precision diagnosis of reproductive abnormalities in cows reveals a reassortant Akabane disease virus.

Background: At the end of 2021, an epidemic of reproductive abnormalities in cows occurred in Jilin Province, China, posing an urgent need for a rapid diagnosis.

Results: To identify the cause of the disease, a total of 172 samples were collected from 21 dead calves and 45 aborting or pregnant cows in 10 farms across the province. Routine PCR or RT-PCR detection did not find any common abortion-related agents.

Ultrasensitive electrochemiluminescencent multivalent aptamer sensor based on energy and electron transfer dual quenching tactics.

An efficient "on-off-on" electrochemiluminescence (ECL) aptasensor utilizing dual-mechanism quenching was constructed for detecting furanyl fentanyl (FuF). The first signal "on" state was achieved by novel dual-ligand zinc metal-organic frameworks (Zn-MOFs), which were synthesized by self-assembly reaction using zinc atom clusters as metal nodes, achieving strong and stable ECL emission. The "off" state was realized by the energy and electron quenching effect of copper-doped WO.

JQR-Net: joint quantitative reconstruction network for dual-modal photoacoustic and optical coherence tomography imaging.

Photoacoustic (PA) and optical coherence tomography (OCT) imaging are complementary imaging modalities with distinct contrast mechanisms, penetration depths, and spatial resolutions. Integrating these two modalities into a dual-modal PA-OCT imaging system enables the simultaneous acquisition of multimodal signals within a single scan. This integration supports quantitative reconstruction of tissue characteristics, offering a more precise and comprehensive analysis than single-modal imaging.