HOXB13 in cancer development: molecular mechanisms and clinical implications.

The transcription factor HOXB13 plays crucial roles in cancer development. HOXB13 is abnormally expressed in most cancers, which makes it a valuable therapeutic target for cancer therapy. The level of HOXB13 differs significantly between healthy and cancer tissues, which indicates that the level of HOXB13 is closely related to carcinogenesis.

Intracorporeal versus extracorporeal neobladder in robot-assisted radical cystectomy: perioperative, oncological, and functional outcomes from a single-institutional experience.

Purpose: To compare the perioperative, functional, and oncological outcomes of the intracorporeal neobladder (ICNB) and extracorporeal neobladder (ECNB) technique following robot-assisted radical cystectomy (RARC).

Methods: We reviewed our single-institutional, prospectively collected database for consecutive patients who underwent RARC with an ileum neobladder from July 2016 to February 2023. Patients were divided into 2 groups according to the approach of reconstruction (ICNB or ECNB).

Prognostic Factors Influencing Postoperative Survival in Patients With Neuroendocrine Carcinoma of the Bladder: A Population-Based Study.

Background: This study aimed to identify prognostic factors influencing survival in patients with bladder neuroendocrine carcinoma (NC).

Methods: This study utilized the Surveillance, Epidemiology, and End Results (SEER) database (2004-2015) to compare NC with urothelial carcinoma (UC). We evaluated the prognostic value of clinicopathological characteristics and survival outcomes for bladder NC patients.

Knockdown of FKBP12.6 may Cause Bladder Dysfunction in Mice by Affecting IP3R/TRPM4 Function.

Background: FKBP12.6 is a crucial calcium regulatory molecule involved in the regulation of bladder excitatory contraction. This study employed FKBP12.

Invasion and metastasis in cancer: molecular insights and therapeutic targets.

The progression of malignant tumors leads to the development of secondary tumors in various organs, including bones, the brain, liver, and lungs. This metastatic process severely impacts the prognosis of patients, significantly affecting their quality of life and survival rates. Research efforts have consistently focused on the intricate mechanisms underlying this process and the corresponding clinical management strategies.

Enabling Thermally Stimulated Delayed Phosphorescence in Cu(I) Cyclic Trinuclear Complexes with Near-Unity Quantum Yield.

Thermally stimulated delayed phosphorescence (TSDP) emission has recently been discovered in several Au(I)/Au(III) complexes, featuring thermally enhanced emission intensities and notable quantum yields (QYs). Developing earth-abundant metal-based TSDP emitters with further increased QYs holds significant promise for practical applications. Herein, we present a halogen bonding approach to achieve TSDP emission in bromo-substituted Cu(I) cyclic trinuclear complexes (CTCs).

Molecular genetic analysis of R124H TGFBIp in one family Avellino corneal dystrophy.

Purpose: The mutation of R124H in TGFBIp causes Avellino corneal dystrophy (ACD, GCD II). However, the molecular mechanisms of ACD caused by the p. R124H mutation are not well understood.

City-level estimation of vehicle CO emission factors regarding driving behaviors: The case of Tianjin, China.

The estimation of CO emission factors (EFs) is a key step in calculating automobile CO emissions. However, city-level research on the integrated estimation of vehicle CO EFs under real conditions is insufficient. To enrich the research methods of city-level vehicle CO EFs, this paper constructs a vehicle-road-driver three-layer regression model and estimates vehicle CO EFs empirical parameters for Tianjin.

SOX2 control activation of dormant prostate cancer cells in bone metastases by promoting CCNE2 gene expression.

Background: Cancer stem cells (CSCs) have a powerful tumor initiation ability, which can promote the early dissemination of single disseminated tumor cells (DTCs), leading to tumor progression. SOX2, a pluripotent inducible transcription factor, is key to maintaining self-renewal and pluripotency of prostate cancer stem cells. However, there is a lack of comprehensive understanding of how SOX2 regulates DTCs dormancy and proliferation in the bone marrow microenvironment.

Toripalimab plus chemotherapy for metastatic muscle-invasive bladder cancer with a high tumor proportion score: a case report.

Background: Radical cystectomy (RC) combined with pelvic lymph node dissection (PLND) is the standard treatment for muscle-invasive bladder cancer (MIBC). For metastatic MIBC patients, platinum-based chemotherapy remains the first choice treatment. However, approximately 50% of patients with metastatic MIBC are ineligible for platinum-based adjuvant chemotherapy because of impaired renal function.

Associations Between the Polymorphisms in the Coding Sequence of SLCO1B1 and Blood Lipid Levels Before and After Treatment by Atorvastatin in the Chinese Han Adults with Dyslipidemia.

Purpose: Atorvastatin is commonly used to treat dyslipidemia; however, individual responses vary considerably. This study endeavors to evaluate the relationship between polymorphisms in the coding sequence (CDS) of SLCO1B1 gene and blood lipid levels before and after atorvastatin treatment among the Chinese Han adults with dyslipidemia.

Patients And Methods: A total of 165 Chinese Han adults undergoing atorvastatin therapy were enrolled in this study and followed up quarterly.

Bone health management in endocrine-treated patients with prostate cancer: a summary of evidence.

Objective: This study aimed to gather and assess the most reliable evidence on bone health management in patients undergoing endocrine therapy for prostate cancer, with the goal of informing clinical practice.

Design And Methods: Utilizing the '6S' evidence model, a comprehensive literature search was conducted across various sources such as computerized decision support systems, national and international guideline networks, society websites, and databases encompassing clinical decision-making, guidelines, systematic reviews, evidence summaries, and expert consensus. The search spanned from April 2014 to April 2024, with two researchers independently evaluating the quality of the identified literature.

Transcriptome-Based Network Analysis Related to Histone Deacetylase Genes and Identified EMP1 as a Potential Biomarker for Prognosis in Bladder Cancer.

Background: Abnormal expression and function of histone deacetylases (HDACs) are closely associated with the development of bladder cancer (BCa). Systematic elucidation of the role of HDACs in BCa is expected to improve BCa prognosis and treatment strategies.

Methods: We explored the correlation and expression patterns of HDAC family genes in BCa.

Dual-mode sensing platform for Bisphenol A detection via bifunctional CsPbBr@Cu-MOF assisted fluorescence and colorimetric analysis.

Background: Bisphenol A (BPA) has been identified as an endocrine disruptor with numerous detrimental effects on human health. There is an urgent need to develop fluorescence/colorimetric dual-mode sensing approaches with expanded detection linear range, increased accuracy, and enhanced application flexibility for BPA detection. The utilization of fluorescence and colorimetric signals in point-of-care applications and real-time sensitive sensing further highlights the significance of developing novel and efficient fluorescence/colorimetric dual-mode sensing platform with high-efficiency probes.

A switch from lysosomal degradation to secretory autophagy initiates osteogenic bone metastasis in prostate cancer.

The identification of both autophagy-related material degradation and unconventional secretion has paved the way for significant breakthroughs linking autophagy to a plethora of physiological processes and disease conditions. However, the mechanisms that coordinate these two pathways remain elusive. Here, we demonstrate that a switch from the lysosomal degradation to a secretory autophagy pathway is governed by protein tyrosine phosphatase 1B (PTP1B, encoded by PTPN1).

Biodegradable iridium coordinated nanodrugs potentiate photodynamic therapy and immunotherapy of lung cancer.

Hypoxia, which is a common characteristic of most solid tumors, not only contributes to the immunosuppressive nature of the tumor microenvironment (TME) but also reduces the efficacy of many oxygen-depleting therapies, including photodynamic therapy (PDT). In this study, we developed acidity-responsive biodegradable iridium-coordinated (IPC) nanodrugs consisting of iridium ions, the photosensitizer chlorin e6 (Ce6), and polyvinylpyrrolidone to potentiate the effects of PDT and immunotherapy by modulating the TME. IPC nanodrugs that accumulate at high levels in tumors catalyze excess hydrogen peroxide to produce oxygen while depleting glutathione levels within cancer cells; thus, the released Ce6 is more efficient at producing reactive oxygen species (ROS) in response to laser irradiation.

Dithiocarbamate fungicides suppress aromatase activity in human and rat aromatase activity depending on structures: 3D-QSAR analysis and molecular simulation.

Dithiocarbamate fungicides have been widely used in agricultural practices due to their effective control of fungal diseases, thereby contributing to global food security and agricultural productivity. In this study, the inhibitory potency of eight compounds on human and rat aromatase (CYP19A1) activity was evaluated. The results revealed that zineb exhibited the highest inhibitory potency on human CYP19A1 (IC, 2.

Development and validation of a simulation training platform for the ligation of deep dorsal vein complex in radical prostatectomy.

Objective: This study aimed to design a low-cost, simulation training platform for the ligation of deep dorsal vein (DVC) complex in radical prostatectomy and validate its training effectiveness.

Methods: A simplified prostate urethra model was produced by 0-degree silica gel and pulse pressure banding. This model was placed on a slope of about 30 degrees using cardboard to thus creating a narrow environment of the pelvis.

Preliminary discrimination and evaluation of clinical application value of ChatGPT4o in bone tumors.

•Evaluation of making up ChatGPT4o in the preliminary pathological diagnosis of bone tumors.•ChatGPT-4o's proficiency in analyzing pathological images and providing initial diagnoses of bone tumor characteristics is comparable to that of senior pathologists in the Tertiary hospital doctors group, with both surpassing the Remote grassroots doctors group.•AI, like ChatGPT-4o, has the potential to enhance diagnostic capabilities for remote grassroots doctors and improve sensitivity to reduce missed diagnosis rates among tertiary hospital doctors in identifying bone tumors.

Drug-coated balloon angioplasty with rescue stenting versus intended stenting for the treatment of patients with de novo coronary artery lesions (REC-CAGEFREE I): an open-label, randomised, non-inferiority trial.

Background: The long-term impact of drug-coated balloon (DCB) angioplasty for the treatment of patients with de novo coronary artery lesions remains uncertain. We aimed to assess the non-inferiority of DCB angioplasty with rescue stenting to intended drug-eluting stent (DES) deployment for patients with de novo, non-complex coronary artery lesions.

Methods: REC-CAGEFREE I was an open-label, randomised, non-inferiority trial conducted at 43 sites in China.

Mapping the constituent preference of tree species for capturing particulate matter on leaf surfaces using single-particle mass spectrometry and supervised machine learning.

Respiratory health is negatively influenced by the dimensions and constituents of particulate matter (PM). Although mass concentration is widely acknowledged to be key to assessing dust retention by urban trees, the role of plant leaves in filtering PM from the urban atmosphere, particularly regarding the particle dimensions and chemical constituents of retained PM on the leaf, remains elusive. Here we combined single-particle aerosol mass spectrometry and a particle resuspension chamber to investigate how urban tree species capture PM constituents.

Feasibility and Safety of Drug-Coated Balloon for Treatment of Coronary Artery Lesions in Large Vessel Disease: A Large-Scale Multicenter Prospective Study.

Background: Drug-coated balloons (DCB) have been evaluated to be safe and practical in treating coronary small vessel disease (SVD). However, evidence about the practicality and safety of DCB in treating coronary lesions with diameters greater than 3.0 mm is limited.