Publications by authors named "Zheng Hui Gu"

Article Synopsis
  • Electromagnetic source imaging (ESI) faces challenges due to its ill-posed nature, often relying on imprecise priors that limit its effectiveness.
  • A new method called data-synthesized spatiotemporally convolutional encoder-decoder network (DST-CedNet) is introduced, treating ESI as a machine learning issue by leveraging discriminative learning and latent-space representations.
  • By using a unique data synthesis strategy that incorporates knowledge about brain activity, DST-CedNet generates large datasets for better training, significantly outperforming traditional ESI methods in accurately estimating brain source signals based on various datasets.
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Free radicals and oxidative stress play an important role in the pathogenesis of noise-induced hearing loss (NIHL). Some ginseng monomers showed certain therapeutic effects in NIHL by scavenging free radicals. Therefore, we hypothesized that ginsenoside Rd (GSRd) may exert neuroprotective effects after noise-induced auditory system damage through a mechanism involving the SIRT1/PGC-1α signaling pathway.

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Endomorphin-1 (EM1) and endomorphin-2 (EM2) are two endogenous ligands that belong to the opioid peptide family and have the highest affinity and selectivity for the µ-opioid receptor (MOR). The neuroanatomical distribution, ultrastructural features and neural circuitry of EM-containing neuronal structures have been morphologically demonstrated. In addition, the modulation effects of the EMs in different areas reflect their potential endogenous roles in many major physiological processes, including their remarkable roles in the transmission and modulation of noxious information.

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