Sphingobium yanoikuyae 41R9 Enhances Nitrogen Uptake by Modulating Transporter Genes and Root Development in Rapeseed.

Plant growth-promoting rhizobacteria (PGPR) are widely recognized for enhancing the absorption of mineral nutrients by crops. While Sphingobium species have been reported as PGPRs, their capacity to improve nitrogen use efficiency (NUE) and the underlying regulatory mechanisms are not yet fully understood. Here, a strain 41R9, isolated from the rhizosphere of N-deficient rapeseed, was found to significantly enhance the growth performance of rapeseed under both low and normal N conditions.

Soft-matter-induced orderings in a solid-state van der Waals heterostructure.

Deoxyribose nucleic acid (DNA), a type of soft matter, is often considered a promising building block to fabricate and investigate hybrid heterostructures with exotic functionalities. However, at this stage, investigations on DNA-enabled nanoelectronics have been largely limited to zero-dimensional (0D) and/or one-dimensional (1D) structures. Exploring their potential in higher dimensions, particularly in combination with hard matter solids such as van der Waals (vdW) two-dimensional (2D) materials, has proven challenging.

Subepicardial adipose genes contribute to the deterioration of heart failure preserved ejection fraction.

Background: The mortality of patients with acute myocardial infarction (MI) raised rapidly in last decade and obesity are becoming the major cause to CAD progression, thus inducing heart failure preserved ejection fraction (HFpEF). However, why visceral adipocytes show different effects on healthy and ageing cardiomyocytes is less known.

Methods: GSE251971 was downloaded and Venn diagram between visceral adipocyte genes genes and DEGs was performed to obtain visceral adipocyte-associated DEGs in heart failure.

Energy storages on the ferroelectric microstructures with transformation and nano vortex pattern.

The energy storage and conversion in ferroelectrics can be realized through the microstructures of polar domains and domain walls, which resulting in the transformations from macro/microdomains to nanodomains or forming complex polar topologies. The physical basic models are adopted with domains and domain walls including 90, 180, 71 and 109 which are classified into two categories of 180 and α-angle, and are reconstructed with equivalent circuits simplified according to the reported patterns. Although electrical energy is known to be maintained by the charging capacitor, the energy storage effect on ferroelectric microstructure has been rarely explored for the relative paucity of experimental patterns reported with domains and domain walls.

ILF3 inhibits p-AMPK expression to drive non-alcoholic fatty liver disease progression.

Background: Non-alcoholic fatty liver disease (NAFLD) is a disease of increasing global prevalence and an important risk factor for the development of insulin resistance, type 2 diabetes, non-alcoholic steatohepatitis and hepatocellular carcinoma, but the pathogenesis is not clear. The aim of this study was to explore the role of ILF3 in NAFLD.

Aim: To investigate the molecular processes through which ILF3 facilitates the advancement of NAFLD by inhibiting the expression of p-AMPK.

Corrigendum: Hounsfield unit for assessing bone mineral density distribution within lumbar vertebrae and its clinical values.

[This corrects the article DOI: 10.3389/fendo.2024.

Integrated analysis of circular economy policy innovations in developing countries through experts' perspectives.

This study explores the barriers and opportunities in implementing circular economy policies within developing countries, focusing on the adaptation of policy innovations through expert perspectives. Developing regions face acute challenges, including environmental degradation and limited resource management infrastructure, making the adoption of circular economy models crucial. However, these models require solutions tailored to local contexts.

Targeted inhibition of NEK7 preventing sepsis-induced cardiomyopathy by inhibiting NLRP3 inflammasome.

Background: Sepsis-induced cardiomyopathy (SIC) is a severe complication of sepsis; however, its pathogenesis remains elusive. This study aims to investigate the role of NMA-related kinase 7 (NEK7) in SIC.

Methods: C57BL/6 mice were stimulated with lipopolysaccharide (LPS) to assess NEK7 expression in the myocardium.

Niche Overlap Between Two Sympatric Steppe Birds in Inner Mongolia: Habitat Selection and Insights for Conservation.

The destruction and degradation of natural ecosystems is a major driver of biodiversity loss. The steppe ecosystem is under threat from human activities and habitat degradation. Fine-scale breeding habitat selection is critical for the survival of steppe birds, but understanding the factors that drive this selection remains challenging.

Mediating role of fall fear and exercise self-efficacy in the nexus between low back pain knowledge and kinesiophobia in pregnancy-related low back pain pregnant women.

To explore relationships among low back pain knowledge, fall fear, exercise self-efficacy and kinesiophobia in pregnant women with pregnancy-related low back pain (PLBP) through a chain mediating model. This study used a cross-sectional survey and utilized convenience sampling from August to December 2023 at a third-class hospital in Wuxi, China. A total of 325 PLBP pregnant women were chosen as the subjects of this study.

Bibliometric analysis of global research status and trends of circadian rhythms in cancer from 2004 to 2024.

Research linking circadian dysregulation to cancer development has received increasing attention recently. However, a comprehensive understanding of research hotspots and trends in this area remains limited. International studies on the circadian rhythms in cancer were retrieved and downloaded from the Web of Science database.

Magnetic beads-based double-stranded DNA fluorescent aptasensor biosensor for deoxynivalenol detection.

Deoxynivalenol (DON) is one of the most harmful mycotoxins that poses great health threats to human and animals. Herein, a simple and sensitive magnetic beads-based fluorescent biosensor was successfully prepared for detection of DON in cereals. A stable double-stranded DNA (dsDNA, biotin-sDNA+FAM-cDNA/AP) was formed on the surface of streptavidin-coated magnetic beads (SMBs).

Design of ROS-Triggered Sesquiterpene Lactone SC Prodrugs as TrxR1 Covalent Inhibitors for the Treatment of Non-Small Cell Lung Cancer.

Thioredoxin reductase 1 (TrxR1) is an important therapeutic target for nonsmall cell lung cancer (NSCLC) treatment due to its overexpression in NSCLC cells. In this work, to address the deficiency that sesquiterpene lactone containing α-methylene-γ-lactone moiety was rapidly metabolized by endogenous nucleophiles, series of novel thioether derivatives were designed and synthesized based on a reactive oxygen species (ROS)-triggered prodrug strategy. Among them, prodrug exhibited potent cytotoxicity against NSCLC cells and better release rates in response to ROS.

Changes in and Potential Mechanisms of Circulating IgA+CD27-Class-Switched Memory B Cells in Patients With Allergic Rhinitis.

Background: The role of memory B cells and their subgroups in allergic rhinitis (AR) and allergen immunotherapy (AIT) remains unclear. This study aimed to investigate the characteristics of memory B cells in the circulation of patients with AR and those undergoing AIT, as well as their clinical significance.

Methods: This study involved a cohort comprising 32 healthy control subjects, 39 individuals diagnosed with AR, and 31 AR patients who had received AIT for over one year.

Ferroelectricity with concomitant Coulomb screening in van der Waals heterostructures.

Interfacial ferroelectricity emerges in non-centrosymmetric heterostructures consisting of non-polar van der Waals (vdW) layers. Ferroelectricity with concomitant Coulomb screening can switch topological currents or superconductivity and simulate synaptic response. So far, it has only been realized in bilayer graphene moiré superlattices, posing stringent requirements to constituent materials and twist angles.

Optimal Synergy between Azulenes and Acenes in Azuacenes with 6-7-5 Ring Topology.

Azuacenes, defined as azulene fused with acenes in a 6-7-5 ring topology and spanning lengths from 3 to 6 rings, have been synthesized using a new skeleton editing and [3 + 2] annulation synthesis protocol as a distinction regarding the procedures to obtain the 6-5-7 isomers. Comprehensive studies on ground-state and excited-state spectroscopy, electrochemical properties, chemical stability, and solid-state structure have been conducted to compare these azuacenes with acenes. For the same number of rings, we found that azuacenes improve the chemical stability of acenes (i.

The dual role of calnexin on malignant progression and tumor microenvironment in glioma.

Glioma is the most common malignant brain tumor. Previous studies have reported that calnexin (CANX) is significantly up-regulated in a variety of malignant tumors, including glioma, but its biological function and mechanism in glioma is still unclear. In this study, differentially expressed proteins in 3 primary glioblastoma multiforme (GBM) tissues and 3 paracancer tissues were identified by liquid chromatography-tandem mass spectrometry-based proteomic and bioinformatic analysis.

Determination of carbonation rate of precipitated calcium carbonate in carbonation process based on headspace gas chromatography.

This paper reports a method for determining the carbonation rate (CR) of precipitated calcium carbonate (PCC) during carbonation process based on headspace gas chromatography technique. The method was carried out by simultaneously detecting the signal values of carbon dioxide and oxygen. Then the carbonation rate of precipitated calcium carbonate in the carbonation process can be calculated by the ratio (γ) of carbon dioxide to oxygen based on a new mathematical model.

Identification and Validation of qRT-PCR Reference Genes for Analyzing Responses to High-Temperature Stress.

Quantitative real-time PCR (qRT-PCR) is an essential tool for analyzing and selecting stable reference genes. In order to screen for suitable reference genes under high-temperature stress conditions in , this study measured the relative expression levels of 17 candidate reference genes using qRT-PCR. Among these, four are traditional reference genes, while the remaining thirteen are candidate reference genes with no previous reports on their use as reference genes.

Discovery of Voreloxin as a Dual-Selective Stabilizer for c-Myc/Bcl-2 G-Quadruplexes in Leukemia.

Overexpression of c-Myc is a key factor in the development of leukemia and other malignancies, highlighting the urgent need for novel drugs to inhibit c-Myc protein levels. DNA G-quadruplexes (G4) have emerged as potential regulatory targets for c-Myc expression. Previous studies identified trovafloxacin, a topoisomerase II inhibitor, as a novel c-Myc G4 stabilizer.

F-FLT PET and Blood-based Biomarkers for Identifying Gastrointestinal Graft versus Host Disease after Allogeneic Cell Transplantation.

Purpose To determine whether fluorine 18 (F) fluorothymidine (FLT) PET imaging alone or combined with Mount Sinai Acute GVHD International Consortium (MAGIC) biomarkers could help identify subclinical gastrointestinal graft versus host disease (GI-GVHD) by day 100 following hematopoietic stem cell transplantation (HSCT). Materials and Methods F-FLT PET imaging was analyzed in a prospective pilot study (ClinicalTrials.gov identifier no.

DcWRKY15 positively regulates anthocyanin biosynthesis during petal coloration in Dianthus caryophyllus.

Petal pigmentation in carnations is closely associated with the biosynthesis of anthocyanins. This biosynthetic process is tightly regulated by transcription factors, which activate or repress key genes involved in anthocyanin production. Here, we aim to explore the mechanisms involved in the transcriptional regulation of anthocyanin biosynthesis in carnation petals.

Magnetic-Electrical Synergetic Control of Non-Volatile States in Bilayer Graphene-CrOCl Heterostructures.

Anti-ferromagnetic insulator chromium oxychloride (CrOCl) has shown peculiar charge transfer and correlation-enhanced emerging properties when interfaced with other van der Waals conductive channels. However, the influence of its spin states to the channel material remains largely unknown. Here, this issue is addressed by directly measuring the density of states in bilayer graphene (BLG) interfaced with CrOCl via a high-precision capacitance measurement technique and a surprising hysteretic behavior in the charging states of the heterostructure is observed.

HMGB1 impacts the intestinal epithelial barrier by initiating NETs to regulate macrophage polarization.

High mobility group box 1 (HMGB1) has the capability of activating the immune response and taking part in macrophage polarization. Despite this, there is significant scope for exploration into how HMGB1 regulates macrophage polarization phenotype and influences intestinal epithelial barrier function. Investigating the role of HMGB1 in the creation of neutrophil extracellular traps (NETs) and the mechanism of its impact on macrophages could provide novel insights into intervening in intestinal inflammation and barrier damage.