Cancer cachexia reduces the efficacy of immune checkpoint inhibitors in cancer patients.

Objective: Cachexia, a multifactorial syndrome, is frequently noticed in cancer patients. A recent study has shown inconsistent findings about the relationship between cachexia and the efficiency of immune checkpoint inhibitors (ICIs). To analyze this disparity, we did a meta-analysis.

Mapping Topsoil Total Nitrogen Using Random Forest and Modified Regression Kriging in Agricultural Areas of Central China.

Accurate understanding of spatial distribution and variability of soil total nitrogen (TN) is critical for the site-specific nitrogen management. Based on 4337 newly obtained soil observations and 33 covariates, this study applied the random forest (RF) algorithm and modified regression kriging (RF combined with residual kriging: RFK, hereafter) model to spatially predict and map topsoil TN content in agricultural areas of Henan Province, central China. According to the RFK prediction, topsoil TN content ranged from 0.

[Clinical, familial and hereditary analysis of myotonic dystrophy].

Objective: To analyze the clinical, familial and hereditary features of myotonic dystrophy to improve the knowledge and provide molecule evidence for gene diagnosis and prenatal diagnosis of myotonic dystrophy or dystrophia myotonia (DM) families.

Methods: Clinical data of 2 DM families were collected based on the probands. The number of trinucleotide CTG repeat in the 3' untranslated region of myotonic dystrophy protein kinase (DMPK) gene on chromosome 19 was determined by DNA sequence and repeat fragment.