Publications by authors named "Zhenen Lin"
Leptin and melatonin's effects on OVX rodents' bone metabolism.
Front Endocrinol (Lausanne)
July 2023
Purpose: This study aims to examine the effects of leptin and melatonin intervention on bone metabolism in ovariectomize (OVX) rodents, as well as their potential mechanisms of action.
Methods: Prepare an OVX model of osteoporosis in rodents and validate the model by collecting bilateral tibia samples for Micro-CT scanning and histological analysis. A control group of normal size, the OVX group, the OVX+Sema4D (Semaphorin 4D) group, the OVX+Sema4D+Leptin group, the OVX+Sema4D+ Melatonin(MT) group and the OVX+Sema4D+Leptin+ MT group were the experimental groups.
Article Synopsis
- The study investigates how leptin and melatonin regulate bone metabolism and their mechanism of action involving Sema4D in an osteoporosis model using ovariectomized rats.
- Techniques like Micro-CT scanning, HE staining, and ELISA were used to analyze bone structure, pathology, and serum estradiol levels, with different treatment groups receiving varying combinations of Sema4D, leptin, and melatonin.
- Results showed that the OVX + Sema4D + leptin and OVX + Sema4D + MT groups had better bone density and structure compared to the OVX control group, indicating a positive regulatory effect on bone metabolism.
Background: Knee osteoarthritis (KOA) seriously affects the quality of life of KOA patients. This study aimed to investigate whether miR-107 could regulate KOA through pyroptosis to affect collagen protein secreted by chondrocytes through IL-1β.
Methods: The proliferation of chondrocytes was detected by CCK-8 assay.
Objective: To analysis the outcome of modified closure bone setting manipulation for the treatment of femoral neck fracture.
Methods: From January 2012 to December 2012, 47 cases of femoral neck fracture were treated and included 25 males and 22 females with an average age of (44.58±10.