Up-regulated ORC1 promotes lung adenocarcinoma by inhibiting ferroptosis via SLC7A11 dependent pathway.

Background: Lung adenocarcinoma (LUAD) is a pulmonary malignant disease that poses a high risk of mortality and morbidity. Previous study indicated that ORC1 plays an oncogenic function. However, the precise regulatory function that ORC1 serves in the progression of LUAD is still not clearly known.

Erbium Single Atom Composite Photocatalysts for Reduction of CO under Visible Light: CO Molecular Activation and 4f Levels as an Electron Transport Bridge.

It is still challenging to design a stable and efficient catalyst for visible-light CO reduction. Here, Er single atom composite photocatalysts are successfully constructed based on both the special role of Er and the special advantages of Zn GeO /g-C N heterojunction in the photocatalysis reduction of CO . Especially, Zn GeO :Er /g-C N obtained by in situ synthesis is not only more conducive to the tight junction of Zn GeO and g-C N , but also more favorable for g-C N to anchor rare-earth atoms.

Aminoantipyrine based efficient chemosensor for Zn(II) ions and its effectiveness in live cell imaging.

A simple imine based receptor NA-1 has been synthesized for detection of Zinc ions. Probe NA-1 showed the selective colorimetric changes with Zinc (II) ions whereas other metal ions didn't showed any observable colorimetric changes. The probe showed the very selective turn-on fluorescence response with Zn(II) ions among other rival metal ions like Cd(II) and Hg(II).

Depletion of SIRT7 sensitizes human non-small cell lung cancer cells to gemcitabine therapy by inhibiting autophagy.

Anti-metabolic therapy, as a major chemotherapy, is an important option in the treatment of lung cancer. However, tumor resistance to cytotoxic chemotherapy has become more common. It has been reported that autophagy is one of the processes contributing to such resistance.