Publications by authors named "Zhencong Guo"
Objectives: This study aims to evaluate the safety and efficacy of BCMA-CD19 compound chimeric antigen receptor T cells (cCAR) to dual reset the humoral and B cell immune system in patients with systemic lupus erythematosus (SLE) with lupus nephritis (LN).
Methods: This is a single-arm open-label multicentre phase 1 study of BCMA and CD19-directed cCAR in patients suffering from SLE/LN with autoantibodies produced by B cells and plasma/long-lived plasma cells. In this clinical trial, we sequentially assigned biopsy-confirmed (classes III-V) LN patients to receive 3×10 cCAR cells/kg postcessation of all SLE medications and conditioning.
Article Synopsis
- Hypoxia is a major stress factor in shrimp farming, and this study investigates the role of microRNAs (miRNAs) in the hypoxic stress response of the whiteleg shrimp Litopenaeus vannamei.
- Through small RNA sequencing, researchers identified 3324 known miRNAs and 8 potential new ones, with 1213 miRNAs showing significant changes in expression under hypoxia, particularly those known to aid in hypoxia tolerance.
- The up-regulated miRNAs are thought to play a crucial role in regulating genes related to hypoxia adaptation, highlighting their importance in processes like gene transcription, cytoskeleton remodeling, and immune defense.