Mechanisms of action of Shizhenqing granules for eczema treatment: Network pharmacology analysis and experimental validation.

Background: Jiuwan decoction has been used to treat chronic eczema since the Qing Dynasty. According to clinical experience, Shizhenqing granules (SZQG), derived from the Jiuwan decoction, exert beneficial clinical effects on acute eczema and reduce recurrence. Therefore, we elucidated the underlying mechanisms of SZQG through network pharmacology, molecular docking, and experimental validation.

Graph embedding-based heterogeneous domain adaptation with domain-invariant feature learning and distributional order preserving.

Heterogeneous domain adaptation (HDA) methods leverage prior knowledge from the source domain to train models for the target domain and address the differences in their feature spaces. However, incorrect alignment of categories and distribution structure disruption may be caused by unlabeled target samples during the domain alignment process for most existing methods, resulting in negative transfer. Additionally, the previous works rarely focus on the robustness and interpretability of the model.

Precision Therapy of Recurrent Breast Cancer through Targeting Different Malignant Tumor Cells with a HER2/CD44-Targeted Hydrogel Nanobot.

Heterogeneity and drug resistance of tumor cells are the leading causes of incurability and poor survival for patients with recurrent breast cancer. In order to accurately deliver the biological anticancer drugs to different subtypes of malignant tumor cells for omnidirectional targeted treatment of recurrent breast cancer, a distinct design is demonstrated by embedding liposome-based nanocomplexes containing pro-apoptotic peptide and survivin siRNA drugs (LPR) into Herceptin/hyaluronic acid cross-linked nanohydrogels (Herceptin-HA) to fabricate a HER2/CD44-targeted hydrogel nanobot (named as ALPR). ALPR delivered cargoes to the cells overexpressing CD44 and HER2, followed by Herceptin-HA biodegradation, subsequently, the exposed lipid component containing DOPE fused with the endosomal membrane and released peptide and siRNA into the cytoplasm.

Ultrafast Charge Carrier Dynamics in InP/ZnSe/ZnS Core/Shell/Shell Quantum Dots.

The excellent performance of InP/ZnSe/ZnS core/shell/shell quantum dots (CSS-QDs) in light-emitting diodes benefits from the introduction of a ZnSe midshell. Understanding the changes of ultrafast carrier dynamics caused by the ZnSe midshell is important for their optoelectronic applications. Herein, we have compared the ultrafast carrier dynamics in CSS-QDs and InP/ZnS core/shell QDs (CS-QDs) using femtosecond transient absorption spectroscopy.

Fuzzy Discriminative Block Representation Learning for Image Feature Extraction.

Representation learning is widely used to project high-dimensional data to low-dimensional subspace for feature extraction in image recognition tasks. However, many related methods barely explore the fuzziness and uncertainty between data classes. Besides, the classical unsupervised sparse constraint weakens the evaluation of feature importance and neglects the preservation of discriminant information during sparse representation.

Studies on fault diagnosis of dissolved oxygen sensor based on GA-SVM.

The present research envisaged the analysis of the dissolved oxygen fault of the water quality monitoring system using the genetic algorithm-support vector machine (GA-SVM). The real-time data collected by the dissolved oxygen sensor was classified into the fault types. The fault types were divided into complete failure fault, impact fault, and constant output fault.

A Spatiotemporal Convolutional Network for Multi-Behavior Recognition of Pigs.

The statistical data of different kinds of behaviors of pigs can reflect their health status. However, the traditional behavior statistics of pigs were obtained and then recorded from the videos through human eyes. In order to reduce labor and time consumption, this paper proposed a pig behavior recognition network with a spatiotemporal convolutional network based on the SlowFast network architecture for behavior classification of five categories.

The mediating role of perceived prejudice in the relationship between self-esteem and psychological distress among Chinese male nursing students.

Male nursing students may experience social prejudice, which may lead to psychological distress. However, few quantitative studies have focused on their mental health. This study aimed to explore the relationship among self-esteem, perceived prejudice, and psychological distress in male nursing students, and compare differences in self-esteem, perceived prejudice, and psychological distress, as well as the relationships among these variables between male nursing students who selected nursing as their first choice for a major and those who did not.

Mounting Behaviour Recognition for Pigs Based on Deep Learning.

For both pigs in commercial farms and biological experimental pigs at breeding bases, mounting behaviour is likely to cause damage such as epidermal wounds, lameness and fractures, and will no doubt reduce animal welfare. The purpose of this paper is to develop an efficient learning algorithm that is able to detect the mounting behaviour of pigs based on the data characteristics of visible light images. Four Göttingen minipigs were selected as experimental subjects and were monitored for a week by a camera that overlooked the pen.

Low post-traumatic stress disorder rate in Chinese in Beijing, China.

Object: There have been significantly fewer community-based, epidemiological studies focusing on PTSD and its socio-demographic correlates among the Chinese than Western populations.

Method: The multistage household cluster random sampling method was used to select participants from18 districts and counties in Beijing; a total of 16,032 participants were assessed; face-to-face interviews and data collection was conducted using the semi-structured clinical interview for DSM-IV-TR Axis I Disorders-Patient Edition (SCID-I/P).

Result: The lifetime PTSD prevalence was 0.

Prevalence of major depressive disorder and socio-demographic correlates: Results of a representative household epidemiological survey in Beijing, China.

Background: Major depressive disorder (MDD) is the most prevalent mental disorder in the general population and has been associated with socioeconomic factors. Beijing has undergone significant socioeconomic changes in last decade, however no large-scale community epidemiological surveys of MDD have been conducted in Beijing since 2003.

Aims: To determine the prevalence of MDD and its socio-demographic correlates in a representative household sample of the general population in Beijing, China.

Superoxide scavenging and Akt inhibition in myocardium ameliorate pressure overload-induced NF-κB activation and cardiac hypertrophy.

Recent studies from our laboratory and others have shown that increases in cytoplasmic superoxide (O(2)(·-)) levels and Akt activation play a key role in agonist-stimulated NF-κB activation and cardiomyocyte hypertrophy in vitro. In this study, we tested the hypothesis that adenovirus (Ad)-mediated intramyocardial gene transfer of cytoplasmic superoxide dismutase (AdCu/ZnSOD) or a dominant-negative form of Akt (AdDNAkt) in mice would attenuate pressure overload-induced increases in activation of the redox-sensitive transcription factor NF-κB and cardiac hypertrophy. Adult C57BL/6 mice were subjected to thoracic aortic banding (TAB) or sham surgery, and intramyocardial injections of viral vectors (AdCu/ZnSOD, AdDNAkt, or control) were performed.

Relationships of sleep duration with sleep disturbances, basic socio-demographic factors, and BMI in Chinese people.

Objective: This study aimed at determining the mean total sleep time (TST) and the relationship between sleep duration and basic socio-demographic factors and BMI sleep problems in Chinese subjects.

Method: A total of 5926 subjects were randomly selected and interviewed using standardized assessment tools.

Results: The reported mean TST was 7.

Alcohol-related disorders in Beijing, China: prevalence, socio-demographic correlates, and unmet need for treatment.

Background: The study aimed to determine the prevalence of alcohol use, episodic heavy drinking, and alcohol dependence and their socio-demographic correlates in Beijing, China. methods: A total of 5,926 subjects were randomly selected in Beijing and interviewed using the Composite International Diagnostic Interview (CIDI 1.0).

The prevalence of insomnia, its sociodemographic and clinical correlates, and treatment in rural and urban regions of Beijing, China: a general population-based survey.

Study Objectives: To determine the prevalence of insomnia, its sociodemographic and clinical correlates, and treatment patterns in Chinese people.

Design: A total of 5,926 subjects were randomly selected in the urban and rural areas of Beijing and interviewed using standardized assessment tools. Basic sociodemographic and clinical data were also collected.

Smoking and psychiatric disorders in the rural and urban regions of Beijing, China: a community-based survey.

Background: In China, there is limited information on smoking and its socio-demographic correlates in general, and in psychiatric patients in particular. The aim of this study was to determine the prevalence of lifetime, current mild, and heavy smoking, the socio-demographic correlates of current smoking, and its relationship with psychiatric disorders in the Beijing municipality, China.

Methods: A total of 5926 subjects who met the study's entry criteria were randomly selected from the urban and rural areas of Beijing and interviewed using standardized assessment tools, including the collection of basic socio-demographic and clinical data.

Prevalence and socio-demographic correlates of major depressive episode in rural and urban areas of Beijing, China.

Objective: This study aimed to determine the 12-month and lifetime prevalence of major depressive episode (MDE) and their socio-demographic correlates in both the urban and rural areas of Beijing, China.

Methods: A total of 4767 adults were randomly selected and interviewed in Beijing using the Composite International Diagnostic Interview (CIDI 1.0).

Prevalence and socio-demographic correlates of schizophrenia in Beijing, China.

Objective: There has been no large-scale survey of schizophrenia in China involving both rural and urban areas using standardized assessment tools and diagnostic criteria. This study aimed to determine the lifetime prevalence of schizophrenia and its socio-demographic correlates in Beijing, China.

Methods: A total of 5926 subjects were randomly selected in Beijing and interviewed using the Composite International Diagnostic Interview (CIDI 1.

SPIDer: Saccharomyces protein-protein interaction database.

Background: Since proteins perform their functions by interacting with one another and with other biomolecules, reconstructing a map of the protein-protein interactions of a cell, experimentally or computationally, is an important first step toward understanding cellular function and machinery of a proteome. Solely derived from the Gene Ontology (GO), we have defined an effective method of reconstructing a yeast protein interaction network by measuring relative specificity similarity (RSS) between two GO terms.

Description: Based on the RSS method, here, we introduce a predicted Saccharomyces protein-protein interaction database called SPIDer.

Upregulation of arginase by H2O2 impairs endothelium-dependent nitric oxide-mediated dilation of coronary arterioles.

Objective: Overproduction of reactive oxygen species such as hydrogen peroxide (H2O2) has been implicated in various cardiovascular diseases. However, mechanism(s) underlying coronary vascular dysfunction induced by H2O2 is unclear. We studied the effect of H2O2 on dilation of coronary arterioles to endothelium-dependent and endothelium-independent agonists.

Microdystrophin gene therapy of cardiomyopathy restores dystrophin-glycoprotein complex and improves sarcolemma integrity in the mdx mouse heart.

Background: More than 90% of Duchenne muscular dystrophy (DMD) patients develop cardiomyopathy, and many die of cardiac failure. Despite tremendous progress in skeletal muscle gene therapy, few attempts have been made to treat cardiomyopathy. Microdystrophin genes are shown to correct skeletal muscle pathological lesions in the mdx mouse model for DMD.