Publications by authors named "Zhenan Zhu"

Aims: Sagittal lumbar pelvic alignment alters with posterior pelvic tilt (PT) following total hip arthroplasty (THA) for developmental dysplasia of the hip (DDH). The individual value of pelvic sagittal inclination (PSI) following rebalancing of lumbar-pelvic alignment is unknown. In different populations, PT regresses in a linear relationship with pelvic incidence (PI).

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  • * Researchers developed a population of 120 recombinant inbred lines (RILs) and identified 14 quantitative trait loci (QTLs) linked to fatty acid composition across various chromosomes, with a notable QTL showing a high LOD score.
  • * Candidate genes involved in fatty acid synthesis were identified in the QTL intervals, indicating potential pathways for enhancing the fatty acid content in rice, which is vital for breeding more nutritious and longer-lasting rice varieties.
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Vitamin B6 (VB6), as an essential component involved in numerous biological activities of animals and plants, reflects the nutritional quality of cereal crops such as rice. Few studies have been conducted to mine the genes controlling the VB6 content in rice grains, and the available studies remain to be deepened. In this study, the recombinant inbred lines created from parents 'HZ' and 'Nekken2' served as the experimental materials.

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Bacterial blight, a major disease in rice, poses a serious impact on rice production. In this study, a doubled haploid (DH) population derived from a cross between the introduced cultivar 'Maybelle' and the landrace 'Baiyeqiu' was used to investigate the pathogenicity of four pathogen races causing bacterial blight. The results showed that the pathogenicity of all the pathogen races exhibited continuous, transgressive distribution in the DH population.

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  • - The study investigates how to accurately determine the acetabular cup reaming center during hip reconstruction surgery for Crowe IV patients with developmental dysplasia of the hip (DDH), addressing a lack of clear anatomical landmarks.
  • - It involves 58 Crowe IV patients, analyzing their acetabular morphology and proposing a method that centers the reaming at the upper two-thirds of the posterior border of the acetabulum, with an average follow-up of 4.1 years.
  • - Results showed that this method led to an 80.20% cup coverage and significant improvement in patients' Harris scores from 39.7 preoperatively to 91.5 postoperatively, indicating successful surgical outcomes.
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  • Autogenous bone grafting has limitations such as limited supply, donor site complications, and challenges in treating large defects, leading to a need for effective bone substitutes.
  • Inspired by the strong structure of mollusk nacre, researchers developed a cerium-doped layered nano-hydroxyapatite/chitosan scaffold (CeHA/CS), which combines the strength of hydroxyapatite with the flexibility of chitosan, mimicking the natural resilience of nacre.
  • Both in vitro and in vivo studies show that CeHA/CS scaffolds significantly promote bone tissue growth and regeneration by enhancing osteogenic gene expression and inhibiting osteoclast formation, indicating their potential as an effective bone substitute.
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Objective: To investigate the clinical and radiological outcomes of distal radius fractures (DRFs) with displaced dorsal ulnar fragments treated with volar locking plate (VLP) and the "poking reduction" technique.

Methods: Between January 2014 and January 2019, 78 unilateral DRFs with displaced dorsal ulnar fragment (AO type C3) treated with VLP were conducted. According to the reduction technique of the dorsal ulnar fragment, the patients were divided into the conventional reduction (CRG) group (33 patients, 14 males and 19 females, mean age 57.

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Background: Mechanical failure, power shortage, and inadvertent contamination of the oscillating saw occasionally occurs in actualizing femoral neck osteotomy during total hip arthroplasty (THA); however, no appropriate alternative solution is currently available. This study aimed to introduce a novel osteotomy instrumentation (fretsaw, jig, cable passer hook) as a substitute tool while the oscillating saw was unavailable during THA.

Methods: This study included 40 patients (40 hips) who underwent femoral neck osteotomy during primary THA using the new osteotomy instrumentation (n = 20) and the oscillating saw (n = 20).

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  • - The study focuses on a new three-dimensional classification system for acetabular bone defects in hip revision surgeries, utilizing additive manufacturing (AM) to create physical models for better assessment and surgical planning.
  • - Researchers evaluated 104 patients and found that three orthopedic surgeons demonstrated high reliability and validity in classifying the defects and developing surgical plans, with inter-observer reliability scores increasing from 0.947 to 0.972 after two weeks.
  • - The findings suggest that this classification system, supported by AM models, provides a reliable and effective method for preoperative evaluations, enhancing the chances of positive surgery outcomes for patients with acetabular defects.
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Background: Lipped or elevated acetabular liners are to improve posterior stability and are widely used in hip arthroplasty. However, concerns of increasing impingement exist when using such liners and optimal orientation of the elevated rim remains unknown. We aimed to identify the impact of lipped liner on the range of motion (ROM) before impingement and propose its optimal orientation.

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  • * A total of 43 patients participated, and a variety of evaluation methods (X-ray, CT-scan, RP tech, and CT-aided RP tech) were used to analyze their anatomy prior to surgery, with surgeons comparing preoperative plans to actual surgical outcomes.
  • * Results showed that RP tech significantly outperformed traditional methods like X-ray and CT in accurately assessing anatomy, achieving an "complete accordance" rate of over 88%, while CT-aided RP tech provided no substantial accuracy improvement over
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Objective: To evaluate accuracy of an innovative "Skywalker" system, a newly designed, robot-assisted operation system for orthopaedics via a clinical trial at knee joint.

Methods: We conducted a prospective analysis of the clinical data of 31 patients who underwent total knee arthroplasty assisted by the "Skywalker" robot (Microport, Suzhou, China) from June 2020 to January 2021. Five male patients and 26 female patients aged 69.

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Background: Single 6 ml Hylan G-F 20 injection, is indicated for knee osteoarthritis patients who have failed to respond to non-pharmacologic therapy and/or simple analgesics. To obtain more thorough understanding of the clinical efficacy and safety, a randomized clinical trial was conducted comparing intra-articular (IA) administration of single 6 ml Hylan G-F 20 injection versus placebo in knee OA patients of Chinese ethnicity.

Methods: This was a randomized, multi-center, double-blind, placebo-controlled clinical trial conducted in 21 centers across China.

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Objective: To evaluate the safety and effectiveness of Qishe Pill () on neck pain in real-world clinical practice.

Methods: A multi-center, prospective, observational surveillance in 8 hospitals across Shanghai was conducted. During patients receiving 4-week Qishe Pill medication, Visual Analogue Scale (VAS) and Neck Disability Index (NDI) assessments have been used to assess their pain and function, while safety monitoring have been observed after 2 and 4 weeks.

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Objective: To compare therapeutic effects of internal fixation with volar locking plate in treating extension and flexion type of distal radius fracture (DRF).

Methods: From January 2015 to June 2018, 103 patients with DRF were retrospectively analyzed. According to original fracture displacement direction, patients were divided into extension fracture(Colles) group and flexion fracture (Smith) group.

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  • Breast cancer bone metastasis is a significant complication leading to issues like tumor recurrence and bone defects.
  • In this study, researchers evaluated the effectiveness of a bioactive scaffold made from graphene oxide and other materials for promoting cell growth, regulating immune responses, and enhancing bone regeneration both in vitro and in vivo.
  • The findings suggest that the new CePO/CS/GO scaffold can effectively kill tumor cells, promote blood vessel formation through macrophage polarization, and aid in bone regeneration, making it a potential treatment option for breast cancer bone metastases.
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Background: The purpose of this study was to investigate the association between the severity of Developmental dysplasia of the hip (DDH) and the abnormality in pelvic incidence (PI).

Methods: This was a retrospective study analyzing 53 DDH patients and 53 non-DDH age-matched controls. Computed tomography images were used to construct three-dimensional pelvic model.

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Objective: This study aimed to investigate the optimal level of femoral neck for measuring femoral anteversion to predict postoperative stem anteversion in Crowe type I developmental dysplasia of the hip.

Methods: This retrospective study analyzed 108 Crowe type I hips that underwent THA between January 2016 and December 2017, including 70 women and 19 men with a mean age of 63.08 ± 9.

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Aseptic loosening caused by wear particles is a common complication after total hip arthroplasty. We investigated the effect of the quercetin on wear particle-mediated macrophage polarization, inflammatory response and osteolysis. In vitro, we verified that Ti particles promoted the differentiation of RAW264.

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Background: The deformity of the proximal femur and acetabular in patients with developmental dysplasia of the hip (DDH) renders an intraoperative decision for ideal component placement challenging. We hypothesized that the altered morphology of calcar femorale (CF) in DDH patients changed the fixation mechanism of the cementless metaphyseal-filling stem and aimed to predict stem anteversion using proximal femoral anatomical parameters from preoperative CT.

Methods: Preoperative and postoperative CT scans of 34 DDHs with a metaphyseal-filling stem in THA were retrospectively analyzed.

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Background: Preoperative planning is fundamental for total hip arthroplasty. This study investigated the optimal femoral neck level for measuring femoral anteversion to predict postoperative stem anteversion in developmental dysplasia of the hip and determined the predictive role of average anteversion based on the sagittal 3-point fixation.

Methods: Sixty-two Crowe type II/III dysplastic hips that underwent total hip arthroplasty were retrospectively analyzed.

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Objective: To assess the changes in alignment of ipsilateral knee joint after total hip arthroplasty (THA) for patients with developmental dysplasia of the hip (DDH).

Methods: Thirty-four patients with DDH (38 hips) who underwent THA between February and December 2008 were included in the study: 4 men and 30 women with a mean age of 56.2 years.

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