Pathomics models for CD40LG expression and prognosis prediction in glioblastoma.

Glioblastoma (GBM) is the most prevalent primary malignant tumor of the nervous system. In this study, we utilized pathomics analysis to explore the expression of CD40LG and its predictive value for the prognosis of GBM patients. We analyzed the expression differences of CD40LG in GBM tissue and normal brain tissue, along with performing survival prognosis analysis.

Laser-induced transverse voltage effect in-axis inclined LaSrTiOthin films prepared by MOCVD.

Light and thermal detectors based on the laser-induced transverse voltage (LITV) effect have garnered significant interest for their rapid and broad spectral response. In this study, we prepared the La-doped SrTiO(STO) epitaxial thin films on the 12° inclined single crystal LaAlO(LAO) (100) substrates using our home-designed metal-organic chemical vapor deposition system. Under the illumination of a 248 nm laser, the LITV signals of LaSrTiOfilms were observed and showed dependence on the La doping level, which can be explained by the changes in the light absorption coefficient, thermal conductivity, and optical penetration depth.

Optimization of An Air-Based Heat Management System for Dusty Particulate Matter-Covered Lithium-Ion Battery Packs.

This study aims to solve the problem of the cell temperature rise and performance decline caused by dusty particulate matter covering the surface of the cell through the allocation of airflow velocities at the inlets of the battery cooling box under the goal of low energy consumption. We take the maximum temperature of the battery pack at a specified airflow velocity and dust-free environment as the expected temperature in a dusty environment. The maximum temperature of the battery pack in a dusty environment is solved at different inlet airflow velocities, which are the boundary conditions of the analysis model constructed in the simulation software.

A pan-cancer analysis reveals the diagnostic and prognostic role of CDCA2 in low-grade glioma.

Background: Cell division cycle associated 2 (CDCA2), a member of the cell division cycle associated proteins (CDCA) family, is crucial in the regulation of cell mitosis and DNA repair. CDCA2 was extensively examined in our work to determine its role in a wide range of cancers.

Methods: CDCA2 differential expression was studied in pan-cancer and in diverse molecular and immunological subgroups in this research.

Design and Optimization Strategies of a High-Performance Vented Box.

This study aims to solve the problems of air flow chaos and poor performance in a vented box caused by the heterogeneous distribution of airflow through the design of the internal structure of the vented box with constant energy consumption. The final goal is to evenly distribute the airflow inside the vented box. Sensitivity analysis was performed for three structural parameters: the number of pipes, the number of holes in the middle pipe, and the number of each increment from the inside to the outside pipe.

Deformation Prediction Theory of Thermal Barrier Coatings near Cooling Holes under Thermal Cycling.

Thermal barrier coating (TBC) systems are widely adopted in gas turbine blades to improve the thermal efficiency of gas turbine engines. However, TBC failure will happen due to the thermal stress between the different layers of the TBC systems. The traditional two-layer theoretical model only considers TGO (thermally grown oxide) and a substrate in the inner cooling hole with the surface uncoated, which results in poor prediction of the deformations of the TBC systems.

Study on the Unsteady Characteristics and Radial Force of a Single-Channel Centrifugal Pump.

To research the internal flow characteristics of a single-channel centrifugal pump, the computational fluid dynamics method is used in this study. Several monitoring points are set on the volute to analyze the change of pressure pulsation and radial force when the impeller rotates at different angles. The results show that the pressure pulsation in the single-channel pump volute is induced by the rotor-stator interaction and its harmonics.

Effect of 3 Transition Metal Atom Intercalation Concentration on the Electronic and Magnetic Properties of Graphene/MoS Heterostructure: A First-Principles Study.

The electronic and magnetic properties of graphene/MoS heterostructures intercalated with 3 transition metal (TM) atoms at different concentrations have been systematically investigated by first principles calculations. The results showed that all the studied systems are thermodynamically stable with large binding energies of about 3.72 eV-6.

Fault Tolerance Optimization of a Lithium Battery Pack Having a Damaged Unit.

As a kind of green and sustainable technology, electric vehicles are continuously highlighted for solving the significant problems of energy and air pollution. In this paper, fault tolerance optimization of an air-cooled lithium battery pack having a damaged unit was considered to improve the heat dissipation performance. For constructing the relationship between the objective function and the design variables, a quadratic polynomial response function was set up based on the experimental points, which were selected by the Latin-hypercube design of experiment method.

Effects of the Design and Optimization of Trapezoidal Channels and Baffles (Number and Position) on the Net Power Density of Proton-Exchange Membrane Fuel Cells.

The effects of the design and optimization of trapezoidal channels and baffles on the net power density of proton-exchange membrane fuel cells (PEMFCs) are studied. The significant effects of the length of upper and lower sides of the trapezoidal cross section and the number and position of baffles on the net power density of PEMFC have been investigated. It is found that at the same flow rate, changing the effective contact surface between the flow channel and the gas diffusion layer can tremendously improve the current density of fuel cells; moreover, the performance of a PEMFC based on the addition of a baffle can be further improved.

MET inhibitor, capmatinib overcomes osimertinib resistance via suppression of MET/Akt/snail signaling in non-small cell lung cancer and decreased generation of cancer-associated fibroblasts.

Background: Patients with non-small cell lung cancer (NSCLC) initially responding to tyrosine kinase inhibitors (TKIs) eventually develop resistance due to accumulating mutations in the EGFR and additional lesser investigated mechanisms such as the participation of the tumor microenvironment (TME).

Methods: Here, we examined the potential for MET inhibitor capmatinib for the treatment of osimertinib-resistant NSCLCs and normalizing the TME.

Results: We first established that HCC827 and H1975 cells showed increased resistance against osimertinib when co-cultured with CAFs isolated from osimertinib-resistant patients.

Circular RNA circHECTD1 facilitates glioma progression by regulating the miR-296-3p/SLC10A7 axis.

Glioma is the most common type of primary brain tumor. Treatment options for recurrent gliomas include surgery, chemotherapy, and radiation therapy, but the clinical outcome is usually limited. In recent years, circular RNAs have been found to play a vital role in several human cancers.

HOXB9 enhances the ability of lung cancer cells to penetrate the blood-brain barrier.

Even after multimodal therapy, the prognosis is dismal for patients with brain metastases from non-small cell lung cancer (NSCLC). Although the blood-brain barrier (BBB) limits tumor cell penetration into the brain parenchyma, some nevertheless colonize brain tissue through mechanisms that are not fully clear. Here we show that homeobox B9 (HOXB9), which is commonly overexpressed in NSCLC, promotes epithelial-to-mesenchymal transition (EMT) and tumor migration and invasion.

SeC Bonding Promoting Fast and Durable Na Storage in Yolk-Shell SnSe @SeC.

Tin-based compounds have received much attention as anode materials for lithium/sodium ion batteries owing to their high theoretical capacity. However, the huge volume change usually leads to the pulverization of electrode, giving rise to a poor cycle performance, which have severely hampered their practical application. Herein, highly durable yolk-shell SnSe nanospheres (SnSe @SeC) are prepared by a multistep templating method, with an in situ gas-phase selenization of the SnO @C hollow nanospheres.

Modulating lncRNA SNHG15/CDK6/miR-627 circuit by palbociclib, overcomes temozolomide resistance and reduces M2-polarization of glioma associated microglia in glioblastoma multiforme.

Background: Accumulating evidence demonstrates the oncogenic roles of lncRNA (long non-coding RNA) molecules in a wide variety of cancer types including glioma. Equally important, However, tumorigenic functions of lncRNA in glioma remain largely unclear. A recent study suggested lncRNA SNHG15 played a role for regulating angiogenesis in glioma but its role in the tumor microenvironment (TME) was not investigated.