TRPC6 is a Biomarker for Prognosis and Immunotherapy of Stomach Adenocarcinoma Based on Bioinformatic Analysis and Experimental Validation.

Background: Transient receptor potential canonical 6 (TRPC6), a key member of the TRPC family, is involved in diverse physiological and pathological processes. Although previous studies have implicated TRPC6 in the progression of stomach adenocarcinoma (STAD), its precise functions and mechanisms remain unclear. Understanding TRPC6's role in STAD may provide insights into its prognostic and therapeutic potential.

Synthesis and fabrication of segregative and durable MnO@chitosan composite aerogel beads for uranium(VI) removal from wastewater.

To address the imperative need for efficient removal of uranium-containing wastewater and mitigate radioactive contamination risks associated with nuclear energy, the development of materials with high removal efficiency and facile separation is crucial. This study designed and synthesised MnO@chitosan (CTS) composite aerogel beads by in-situ growing δ-MnO on porous CTS aerogel beads. This approach not only mitigates the agglomeration of MnO nanospheres but also significantly enhances the porous structure and surface area of MnO@CTS.

State of art on the mechanisms of laparoscopic sleeve gastrectomy in treating type 2 diabetes mellitus.

Obesity and type-2 diabetes mellitus (T2DM) are metabolic disorders. Obesity increases the risk of T2DM, and as obesity is becoming increasingly common, more individuals suffer from T2DM, which poses a considerable burden on health systems. Traditionally, pharmaceutical therapy together with lifestyle changes is used to treat obesity and T2DM to decrease the incidence of comorbidities and all-cause mortality and to increase life expectancy.

Pan-cancer analysis confirms the prognostic and immunological effects of prostate tumor overexpressed-1 in human cancers.

Background: Prostate tumor overexpressed-1 (PTOV1) is a conserved oncogenic adaptor protein associated with cancer progression and may be an independent prognostic marker for several malignancies. Consequently, using pan-cancer research to explore the significance of PTOV1 is valuable, and may reveal novel targets for cancer treatment.

Methods: A comprehensive bioinformatics analysis of PTOV1 was performed.

The predictive value of preoperative luteinizing hormone to follicle stimulating hormone ratio for ovulation abnormalities recovery after laparoscopic sleeve gastrectomy: A prospective cohort study.

Introduction: Obesity-related ovulation abnormalities (OA) affect fertility. LSG is the most frequent bariatric operation. However, no research has identified a reliable indicator for predicting OA recovery after LSG.

Three-dimension titanium phosphate aerogel for selective removal of radioactive strontium(II) from contaminated waters.

The effective removal of radioactive strontium (especially Sr) from nuclear wastewater is crucial to environmental safety. Nevertheless, materials with excellent selectivity in Sr removal remain a challenge since the similarity with alkaline earth metal ions in the liquid phase. In this work, a novel titanium phosphate (TiP) aerogel was investigated for Sr(II) removal from the radioactive wastewater based on the sol-gel method and supercritical drying technique.

Synthesis of Novel Hierarchical Rod-like Mg-Al bimetallic oxides for enhanced removal of uranium (VI) from wastewater.

As one of the most frequently used nuclides for nuclear fuel and toxic heavy metal in polluted solutions, the removal and recovery of U(VI) from wastewater is significant both for nuclear energy and human health. Herein, the novel hierarchical Mg-Al bimetallic oxides (Mg/Al-BOs) were successfully synthesized by a facile hydrothermal-lyophilization-calcination method for enhanced removal of uranium (U(VI)) from wastewater. The as-synthesized Mg/Al-BOs adsorbents were characterized by a variety of techniques including SEM-EDS, XRD, high temperature in-situ XRD, TG-DSC, N adsorption-desorption isotherm and XPS.

Long Noncoding RNA DLX6-AS1 Regulates the Growth and Aggressiveness of Colorectal Cancer Cells Via Mediating the miR-26a/EZH2 Axis.

To understand the regulation of long noncoding RNA DLX6-AS1-mediated miR-26a/EZH2 axis in the growth of colorectal cancer (CRC) cells. The expression of DLX6-AS1, miR-26a, and EZH2 was detected in CRC tissues by quantitative reverse transcription-polymerase chain reaction. The CRC HT-29 cell line was selected for transfection and subjected to observe the growth by MTT and colony formation assays, cell cycle by flow cytometry, and migration and invasion by wound healing and Transwell assays, respectively.

Removal of V(V) From Solution Using a Silica-Supported Primary Amine Resin: Batch Studies, Experimental Analysis, and Mathematical Modeling.

Every year, a large quantity of vanadium-containing wastewater is discharged from industrial factories, resulting in severe environmental problems. In particular, V(V) is recognized as a potentially hazardous contaminant due to its high mobility and toxicity, and it has received considerable attention. In this study, a silica-supported primary amine resin (SiPAR) was prepared by in-situ polymerization, and the V(V) adsorption from the solution was examined.

Mesenchymal stem cells overexpressing hepatocyte nuclear factor-4 alpha alleviate liver injury by modulating anti-inflammatory functions in mice.

Background: Mesenchymal stem cells (MSCs) can migrate to tissue injury sites where they can induce multipotential differentiation and anti-inflammation effects to treat tissue injury. When traditional therapeutic methods do not work, MSCs are considered to be one of the best candidates for cell therapy. MSCs have been used for treating several injury- and inflammation-associated diseases, including liver cirrhosis.

Combined detection tumor markers for diagnosis and prognosis of gallbladder cancer.

Aim: To clarify the value of combined use of markers for the diagnosis of gallbladder cancer and prediction of its prognosis.

Methods: Serum cancer antigens (CA)199, CA242, carcinoembryonic antigen (CEA), and CA125 levels were measured in 78 patients with gallbladder cancer (GBC), 78 patients with benign gallbladder diseases, and 78 healthy controls using electrochemiluminescence. CA199, CA242, CEA, and CA125 levels and positive rates were analyzed and evaluated pre- and post-operatively.