Effects of LncRNA MYOSLID and MiR-29c-3p on the Proliferation and Migration of Angiotensin II-induced Vascular Smooth Muscle Cells.

Atherosclerosis (ATH) represents a major cause of cardiovascular disease. Long noncoding RNA (LncRNA) myocardin-induced smooth muscle lncRNA, inducer of differentiation (MYOSLID) and microRNA (miR) -29c-3p show substantial roles in ATH. We investigated their regulatory mechanisms on vascular smooth muscle cell (VSMC) proliferation and migration.

Experimental investigation on mechanical properties and strength criteria of frozen soft rock.

Excavation of underground engineering structures involving deeply buried water-rich soft rocks is generally carried out using the artificial freezing method. A series of undrained uniaxial and triaxial shear and creep tests were conducted on soft rocks under different confining pressures (0, 0.2, 0.

Structure-based method for the discovery of selective inhibitors of PED 5 in erectile dysfunction therapy from the Pacific oyster peptides (Crassostrea gigas): Peptidomic analysis, molecular docking, and activity validation.

Erectile dysfunction (ED) is a male sexual disorder mainly caused by a reduction in the cellular concentration of cyclic guanosine monophosphate (cGMP), which is degraded by phosphodiesterase type-5 (PDE-5). Oyster protein (OP) and its hydrolysates have been used for centuries to address male erectile dysfunction, however the mechanisms and evidence supporting their efficacy remain unclear. In this study, OP was hydrolyzed using trypsin to produce peptides that inhibit PDE-5.

Large and Small Yellow Croakers Feeding and Living Together Make Large Yellow Croaker Population Recovery Difficult: A Guild Perspective.

In recent decades, China's large-scale stock enhancement programs to restore the collapsing large yellow croaker () fishery resources have not yielded the desired results, and a comprehensive analysis of the underlying reasons for this problem is required. Based on small yellow croaker () catch survey data obtained from 15 fishing ports along the coast of the East China Sea, we examined the proportion of large yellow croakers mixed in the small yellow croaker catch and their biological parameters. In addition, we analyzed the differences in the intestinal microbiota and feeding ecology between these two species to explore the reason why the stock enhancement program failed to achieve the desired outcome.

Statistical damage constitutive model of soft rock based on Improved Hoek-Brown strength criterion.

It is significant to study the stability of surrounding rock in soft rock tunnels to ensure construction safety and improve efficiency. Through triaxial shear tests on soft rock at various confining pressures, we observed the failure characteristics transitioning from strain softening to strain hardening as confining pressure increases. An improved Hoek-Brown strength criterion has been proposed to characterize the critical confining pressure effect of soft rock, with tensile strength in the tensile zone aligning with experimental results, showing an error of less than 5%.

Consecutive high-efficient water-saving irrigation increase crop yield and decrease soil salinity through reconstructing rhizosphere soil bacterial communities.

Roughly 10 % of the world's arable land is affected by salinization, which significantly reducing crop yields, degrading soil health, and posing a serious threat to food security and ecological stability. High-efficient water-saving irrigation (HEI) technologies have showed positive effects on crop yield, especially with long-term application in salinized soil fields. However, the microbial mechanisms and influential pathways that promote crop yield and reduce salinity under consecutive HEI remain unclear.

[Correlation between inflammatory factors in gingival crevicular fluid and implant stability after oral implant restoration].

Purpose: To analyze the effect of n-HA/chitosan/minocycline composite scaffold in the animal model of peri-implant inflammatory bone defect.

Methods: Twelve healthy adult male beagle dogs were selected to construct the model of peri-implant inflammatory bone defect. The control group(n=6) underwent bone regeneration by alveolar self-healing without any treatment in the bone defect area.

Efficient extraction and analysis method for lead-containing nanoparticles in complex biological samples to eliminate "false" interferences by using SP-ICP-MS.

Metal-containing nanoparticles (MNPs) ubiquitously exist in the environment and organisms, playing distinct roles in the fate and toxicity of metals. However, the extraction and analysis of the MNPs in biological samples is still a great challenge and the interferences of other metal species and complex matrices remains unclear. In this work, we established a method for efficient extraction and accurate analysis of MNPs in biological samples to eliminate the interference caused by metal ions and biological matrices based on the alkali extraction and single particle mode inductively coupled plasma mass spectrometry (SP-ICP-MS).

An Efficient Tri-Conductive Electrode for Ethane Direct Electrochemical Dehydrogenation on Proton Ceramic Electrolysis Cells.

The preparation of ethylene from ethane, a main component of shale gas, has become an important process of the petrochemical industry, using ethane steam cracking at high temperatures (>900 °C), which is a highly energy intensive industry. Here, direct dehydrogenation of ethane is engineered electrochemically to produce ethylene and hydrogen in a proton-conducting electrolysis cell, achieving over 50% ethane conversion and 90.42% ethylene selectivity at 700 °C.

Metal artifact suppression in terahertz computed tomography.

Metal artifact suppression in images of terahertz computed tomography is a bottleneck problem that hinders the development of this technique, and few studies have been conducted so far. In this paper, we propose a metal artifact suppression method containing 8 steps based on the idea of sinogram restoration. The method has been applied to the slice images of several metal objects and the effects before and after metal artifact suppression have been compared to verify the effectiveness of the method.

Process-based modeling to reveal spatio-temporal variations of coastal wetland-mediated nutrient removal.

Nutrient pollution intensifies the strain on coastal ecosystems globally. Despite wetlands' significant nutrient removal potential, process-based assessments of nutrient removal in large-scale coastal wetlands face limitations that hinder accurate quantification of water quality improvements. This study proposes a novel quantitative approach by developing a coupled hydrodynamic-water quality-wetland biogeochemical model.

Enhanced visible-light-driven photocatalytic degradation via in-situ AIS/ZIS high-low junctions.

The I-III-VI QDs Ag-In-S (AIS) exhibits excellent properties in photocatalysis because of the adjustable band gap, wide light absorption range, and multiple active sites. Introducing homologous or heterogeneous ions not only derives the composition into quaternary/ quinary quantum dots but also generates new sulfide QDs to form composites, which is an effective strategy to promote photoactivity. In this work, we in-situ synthesized the AIS/ZIS (AgInS/ZnInS) composite photocatalyst by introducing Zn and changing the reaction temperature.

The gut microbiome in patients with Cushing's disease affects depression- and anxiety-like behavior in mice.

Background: Depression and anxiety significantly impact the quality of life in individuals with Cushing's disease (CD), which originates from pituitary neuroendocrine tumors (PitNETs), yet our understanding of the underlying mechanisms is limited. There is substantial evidence linking gut microbes to depression, anxiety, and endocrinology.

Results: The gut bacterial phenotype of patients with Cushing's disease was significantly different from that of the control group, and when the mice were treated with fecal bacteria from these patients, both anxiety- and depression-like behavior were significantly increased.

Hierarchical Ordered Mesoporous SrBiTiO Microflowers with Rich Oxygen Vacancies In Situ Assembled by Nanosheets for Piezo-Photocatalysis.

The Aurivillius phase layered perovskite ferroelectric material SrBiTiO (SBTO) exhibits spontaneous polarization and piezoelectric properties, which confer significant potential for piezo-photocatalysis. Its ability to enhance electron-hole separation while providing excellent fatigue resistance positions it as a promising candidate in this field. Defects were introduced to improve the structural polarization and photoelectrochemical properties of SBTO.

The AKR1C1-CYP1B1-cAMP signaling axis controls tumorigenicity and ferroptosis susceptibility of extrahepatic cholangiocarcinoma.

Extrahepatic cholangiocarcinoma (ECC), a highly malignant type of cancer with increasing incidence, has a poor prognosis due to limited treatment options. Based on genomic analysis of ECC patient samples, here we report that aldo-keto reductase family 1 member C1 (AKR1C1) is highly expressed in human ECC tissues and closely associated with ECC progression and poor prognosis. Intriguingly, we show that inducible AKR1C1 knockdown triggers ECC cells to undergo ferroptosis.

eDNA technology reveals fish species diversity and ecological corridor function in large raft mussel aquaculture area in the East China Sea.

Human activities have transformed coastal environments by introducing numerous artificial structures that impact local ecosystems. Our study investigated fish species diversity in the mussel farm (MF) and the surrounding natural reef habitat (NH) around Gouqi Island in the East China Sea (ECS). Gouqi Island, which hosts the largest mussel farm in ESC, is also a critical region for marine fish activity.

MiR-21-3p inhibitor exerts myocardial protective effects by altering macrophage polarization state and reducing excessive mitophagy.

Chronic heart failure (CHF) is closely associated with inflammation and mitochondrial dysfunction in cardiomyocytes. This study attempts to investigate the effects of microRNA-21-3p (miR-21-3p) on macrophage polarization and mitophagy in CHF. Here we found miR-21-3p was upregulated in CHF and negatively correlated with carnitine palmitoyl transferase 1A (CPT1A).

Unlocking the ecohydrological dynamics of vegetation growth's impact on Terrestrial Water Storage trends across the China-Pakistan Economic Corridor.

Studying the influence of vegetation dynamics on water storage is fundamental for efficiently managing ecosystems in dryland areas. Therefore, this study was designed to investigate the ecohydrological dynamics of vegetation growth's impact on Terrestrial Water Storage (TWS) trends across the China-Pakistan Economic Corridor (CPEC). Exploring vegetation growth's effect on TWS utilizes remote sensing and statistical methods such as generalized additive model (GAM), random forest, Mann-Kendall test, Sen's slope, and Partial correlation coefficient.

Total Iridoid Glycosides from Franch. Alleviate Cholestasis Induced by α-Naphthyl Isothiocyanate through Activating the Farnesoid X Receptor and Inhibiting Oxidative Stress.

Cholestasis refers to a physiological and pathological process caused by bile acid (BA) overaccumulation inside the circulatory system and liver, leading to systemic and hepatocellular damage. Activating the farnesol X receptor (FXR) to restore BA homeostasis is a promising strategy for treating cholestasis. The objective of this research is to reveal solid evidence for the fact that the total iridoid glycosides from Franch.

Quantitatively unveiling the role of coastal wetlands in regulating eutrophication and enhancing water environmental capacity.

Human activities have intensified the global challenge of coastal eutrophication. Recently, water resource managers have encountered difficulties in formulating precise pollutant reduction strategies to mitigate coastal eutrophication. Despite the recognized importance of coastal wetlands and pollution sources in influencing coastal nutrient levels, accurately quantifying their impact remains difficult.

Quantitative investigation and intelligent forecasting of thermal conductivity in lime-modified red clay.

This paper delves into the engineering applications of lime-stabilized red clay, a highly water-sensitive material, particularly in the context of the climatic conditions prevalent in the Dalian region. We systematically investigate the impact of water content, dry density, and freeze-thaw cycles (with a freezing temperature set at -10°C) on the thermal conductivity of stabilized soil, a crucial parameter for analyzing soil temperature fields that is influenced by numerous factors. By developing and validating both empirical and machine learning prediction models, we unravel the evolution of thermal conductivity in response to these factors: within the range of influencing variables, thermal conductivity exhibits an exponential or linear increase with rising water content and dry density, while it decreases exponentially with increasing freeze-thaw cycles.

Comparative transcriptomic analysis of goose astrovirus genotype 1 and 2 in goose embryonic fibroblasts.

Gout in goslings has become widespread and caused huge economic losses for the goose industry. Emerging evidence suggests that goose astrovirus (GAstV) is a prominent etiological factor of gout in goslings. At present, 2 genotypes of GAstV have been identified named GAstV-1 and GAstV-2.