Alternative Splicing Analysis Reveals Adrenergic Signaling as a Novel Target for Protein Arginine Methyltransferase 5 (PRMT5) in the Heart.

Adrenergic signaling is critical for maintaining cardiac function and works by regulating heart rate, contractility, and stress responses. Protein arginine methyltransferase 5 (PRMT5), a key enzyme involved in gene expression, signal transduction, and RNA processing, has been revealed to be an important factor in heart disease. However, its specific effects on adrenergic signaling have not been fully elucidated.

Adhesion-Assisted Antioxidant-Engineered Mesenchymal Stromal Cells for Enhanced Cardiac Repair in Myocardial Infarction.

Mesenchymal stromal cell (MSC) therapy holds great promise for treating myocardial infarction (MI). However, the inflammatory and reactive oxygen species (ROS)-rich environment in infarcted myocardium challenges MSC survival, limiting its therapeutic impact. In this study, we demonstrate that chemical modification of MSCs with anti-VCAM1 and polydopamine (PD) significantly enhances MSC survival and promotes cardiac repair.

Ultrasensitive terahertz metasensor integrated with EIT-like coupling and liquid flow micro-channels for organic solvent detection and identification.

Terahertz (THz)-based metasurface sensors offer potential and extensive application prospects for organic solvent detection. This study proposed a liquid sensor comprising an electromagnetically induced transparency (EIT)-like THz metasurface covered by a channel. The designed device can exploit variations in the EIT-like resonance peaks to distinguish between the concentrations of three types of organic solvents (ethanol(ET), acetone(AC), and isopropyl alcohol(IPA)).

Discovery and characterization of a novel alginate lyase PeAly15 and its truncated protein DUF4962 domain from Paenibacillus elgii HSFD1: Elucidation the molecular mechanism of endolytic mode.

Exolytic alginate lyases belonging to the PL15 family consist of two distinct domains: DUF4962 and Hepar_II_III. However, the specific functional roles of these domains have been scarcely investigated. In this study, we identified a novel alginate lyase, designated PeAly15, through comprehensive genomic analysis of the alginate-degrading bacterium Paenibacillus elgii HSFD1.

A Case of Pulmonary Bulla Volume Reduction by Transbronchial Puncture Under Electromagnetic Navigation Platform Combined With O-Arm CT Guidance.

Pulmonary bullae are a common complication of chronic obstructive pulmonary disease (COPD), but treatment options are limited for patients with poor lung function and giant emphysematous bullae (GEB). We reported a case of a 61-year-old female with severe COPD complicated by a newly developed GEB. Using electromagnetic navigation technology, we precisely located and targeted the bronchi adjacent to the bullae within the lung.

Incorporating Ordered Indium Sites into Rhodium for Ultra-Low Potential Electrocatalytic Conversion of Ethylene Glycol to Glycolic Acid.

The upcycling of polyethylene terephthalate (PET)-derived ethylene glycol (EG) to glycolic acid (GA, a biodegradable polymer monomer) via electrocatalysis not only produces valuable chemicals but also mitigates plastic pollution. However, the current reports for electrooxidation of EG-to-GA usually operate at reaction potentials of >1.0 V vs reversible hydrogen electrode (RHE), much higher than the theoretical potential (0.

Comparative Chloroplast Genomics and Codon Usage Bias Analysis in Genus.

Objectives: This study investigates the cpDNA sequences from six species, aiming to explore their genomic characteristics, gene content, and genetic relationships. The objectives include understanding the structure of these genomes, identifying potential gene rearrangements, and providing insights into genetic improvement and conservation strategies for the genus.

Methods: cpDNA sequences from six species were sequenced and analyzed.

Stabilizing Lattice Oxygen to Enable Durable MnO Electrocatalyst for Simultaneous Acidic Hydrogen Production and Biomass Valorization.

Understanding and steering the stability of earth-abundant electrocatalysts in acidic medium is essential for proton exchange membrane (PEM) water electrolyzer. Manganese oxide (MnO) is one of the promising candidates for acidic oxygen evolution reaction (OER), but it still suffers from the overoxidation and the underlying mechanism remains elusive. Here, we observed that lattice oxygen was involved in the OER process on γ-MnO via Mars-van-Krevelen mechanism.

Facilitating OH* Generation on Atomic Pd-Cu Dual Sites towards Efficient Glycerol Electrooxidation to Formate.

The electrocatalytic glycerol oxidation reaction (GOR) represents a mild and sustainable pathway to produce value-added chemicals such as formate. However, the rational design and controlled synthesis of efficient catalysts to achieve highly selective C-C bond cleavage of glycerol towards formate remains a great challenge. Herein, atomic Pd doped CuN hollow nanocubes with Pd-Cu dual sites were prepared via the unique Kirkendall process, exhibiting superior electrocatalytic GOR activity and selectivity towards formate with a maximum Faraday efficiency of 91.

A Spatially Distributed Microneedle System for Bioorthogonal T Cell-Guided Cancer Therapy.

Chimeric antigen receptor (CAR)-T cell therapy represents a promising strategy for cancer treatment. However, the diversity of solid tumor antigens and the poor infiltration of CAR-T cells significantly hinder the efficacy of CAR-T therapies against tumors. Here, a spatially distributed microneedle system (SDMNS) is developed that leverages bioorthogonal reactions to activate and guide endogenous T cells to tumors for effective destruction.

Elucidation of molecular recognition of catecholamine enantiomer by cyclodextrin combined ion mobility spectrometry and theoretical calculation.

Catecholamines, as important neurotransmitter and clinical drugs, have a wide range of regulatory roles in physiological activities. The recognition of catecholamine enantiomer (CE) and the elucidation of recognition mechanism are of great significance for the in-depth understanding of biomolecular interactions. This work reveals the molecular recognition mechanism of cyclodextrin (CD) towards CEs through experimental measurements of ion mobility spectrometry (IMS) and theoretical studies including molecular dynamics (MD) simulation and quantum chemical (QC) calculation.

Nonlinear Kondo transport through serially coupled double quantum dots.

We study the transport property through the serially coupled double quantum dots (DQDs) system with Kondo resonance based on the dissipation equation of motion theory. A nonlinear behavior of the transport current is exhibited due to the competition between the interdot coupling strength of the two QDs and the Kondo effect. With the increase in interdot coupling strength, the transport current first increases at low interdot couplings and then decreases with the strong interdot couplings.

Superhydrophobic Luminescent Pixel Array Based on Perovskite Quantum Dots for Outdoor Displays.

Perovskite quantum dots (PQDs) have garnered significant attention in the display industry as high-performance luminescent materials in recent years. However, in outdoor applications, it is highly challenging to maintain the luminescent performance of PQDs while simultaneously ensuring superhydrophobicity and self-cleaning functionality in rainy weather conditions. Here, we report a luminescent pixel array fabricated using superhydrophobic PQDs with a photoluminescence quantum yield (PLQY) of 32%.

Chemical upcycling of Ni from electroplating wastewater into a well-defined catalyst for electrooxidation of glycerol to formate.

Highly effective and efficient remediation of hazardous Ni waste from electroless electroplating wastewater remains a significant challenge. However, rather than regarding it as hazardous waste, Ni-electroplating wastewater can instead be considered a huge resource of Ni. Herein, we report a convenient hydrothermal strategy for upcycling Ni from nickel-electroplating wastewater into a carbon-doped Ni-P alloy (denoted as C/Ni-P) electrocatalyst for the oxidation of glycerol to formate.

Molecular and pharmacological heterogeneity of ETV6::RUNX1 acute lymphoblastic leukemia.

ETV6::RUNX1 is the most common fusion gene in childhood acute lymphoblastic leukemia (ALL) associated with favorable prognosis, but the optimal therapy for this subtype remains unclear. Profiling the genomic and pharmacological landscape of 194 pediatric ETV6::RUNX1 ALL cases, we uncover two transcriptomic clusters, C1 (61%) and C2 (39%). Compared to C1, the C2 subtype features higher white blood cell counts and younger age at diagnosis, as well as better early treatment responses.

Low folate biomarker concentrations are associated with increase the risk and severity of periodontitis in adults: A cross-sectional study based on the National Health and Nutrition Examination Survey 2009-2014.

We sought to test the hypothesis that adult folate biomarker concentrations are negatively associated with the risk and severity of periodontitis. Data were pooled from the National Health and Nutrition Examination Survey (NHANES) 2009 to 2014. A total of 9252 dentate adult subjects aged 30 years and older who received a periodontal examination and had complete folate biomarker data were included in the analysis.

Predicting residual pain after vertebral augmentation in vertebral compression fractures: a systematic review and critical appraisal of risk prediction models.

Background: Patients with vertebral compression fractures may experience unpredictable residual pain following vertebral augmentation. Clinical prediction models have shown potential for early prevention and intervention of such residual pain. However, studies focusing on the quality and accuracy of these prediction models are lacking.

Targeting tubulin protein to combat fungal disease: Design, synthesis, and its new mechanistic insights of benzimidazole hydrazone derivatives.

As the vital the biomacromolecule in eukaryotic cells, tubulin protein is essential for preserving cell shape, facilitating cell division, and cell viability. Tubulin has been approved as promising target for anticancer, and antifungal therapy. However, there are still many gaps in tubulin-targeted fungicidal discovery.

Different p-block elements induce C[111] octahedral distortion in titanium to generate an intense nonlinear effect.

Acentric crystalline materials are the cornerstone of numerous cutting-edge technologies and have been highly sought-after, but they are difficult to construct controllably. Herein, by introducing a new p-block element to break the symmetrical environment of the d transition metal in the centric matrix TiTeO, a novel acentric tellurite sulfate, namely Ti(TeO)(SO), was successfully constructed. In its structure, two types of p-block element-centered oxo-anionic groups, [TeO] and [SO], endow [TiO] with an out-of-center distortion along the local C[111] direction, which is rare in titanium oxides containing a lone-pair cation.

Utilizing deep learning for automatic segmentation of the cochleae in temporal bone computed tomography.

Background: Segmentation of the cochlea in temporal bone computed tomography (CT) is the basis for image-guided otologic surgery. Manual segmentation is time-consuming and laborious.

Purpose: To assess the utility of deep learning analysis in automatic segmentation of the cochleae in temporal bone CT to differentiate abnormal images from normal images.

Efficient Photocatalytic Propane Direct Dehydrogenation to Propylene Over PtO Clusters.

The direct dehydrogenation of alkanes to olefins under mild conditions is challenging due to the inert nature of alkyl C─H bonds. Herein, an efficient photocatalytic system is developed for propane direct dehydrogenation (PDH) to propylene, consisting of ≈1.30 nm sized PtO clusters immobilized on a layered double hydroxide -derived ZnO/AlO support (LD-Pt).

Unraveling Various Stacking Modes and Local Structures in Poly(triazine imide) Materials via Low-Dose Electron Microscopy.

Poly(triazine imide) (PTI) materials, a class of layered graphitic carbon nitrides, have garnered significant attention for their unique electronic, thermal, and catalytic properties. These properties can be adjusted through postsynthesis treatments. However, the influence of these treatments on the layer stacking modes and local structures within PTI remains largely unexplored.