Adrenergic signaling is critical for maintaining cardiac function and works by regulating heart rate, contractility, and stress responses. Protein arginine methyltransferase 5 (PRMT5), a key enzyme involved in gene expression, signal transduction, and RNA processing, has been revealed to be an important factor in heart disease. However, its specific effects on adrenergic signaling have not been fully elucidated.
View Article and Find Full Text PDFMesenchymal stromal cell (MSC) therapy holds great promise for treating myocardial infarction (MI). However, the inflammatory and reactive oxygen species (ROS)-rich environment in infarcted myocardium challenges MSC survival, limiting its therapeutic impact. In this study, we demonstrate that chemical modification of MSCs with anti-VCAM1 and polydopamine (PD) significantly enhances MSC survival and promotes cardiac repair.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
March 2025
Terahertz (THz)-based metasurface sensors offer potential and extensive application prospects for organic solvent detection. This study proposed a liquid sensor comprising an electromagnetically induced transparency (EIT)-like THz metasurface covered by a channel. The designed device can exploit variations in the EIT-like resonance peaks to distinguish between the concentrations of three types of organic solvents (ethanol(ET), acetone(AC), and isopropyl alcohol(IPA)).
View Article and Find Full Text PDFExolytic alginate lyases belonging to the PL15 family consist of two distinct domains: DUF4962 and Hepar_II_III. However, the specific functional roles of these domains have been scarcely investigated. In this study, we identified a novel alginate lyase, designated PeAly15, through comprehensive genomic analysis of the alginate-degrading bacterium Paenibacillus elgii HSFD1.
View Article and Find Full Text PDFPulmonary bullae are a common complication of chronic obstructive pulmonary disease (COPD), but treatment options are limited for patients with poor lung function and giant emphysematous bullae (GEB). We reported a case of a 61-year-old female with severe COPD complicated by a newly developed GEB. Using electromagnetic navigation technology, we precisely located and targeted the bronchi adjacent to the bullae within the lung.
View Article and Find Full Text PDFThe upcycling of polyethylene terephthalate (PET)-derived ethylene glycol (EG) to glycolic acid (GA, a biodegradable polymer monomer) via electrocatalysis not only produces valuable chemicals but also mitigates plastic pollution. However, the current reports for electrooxidation of EG-to-GA usually operate at reaction potentials of >1.0 V vs reversible hydrogen electrode (RHE), much higher than the theoretical potential (0.
View Article and Find Full Text PDFObjectives: This study investigates the cpDNA sequences from six species, aiming to explore their genomic characteristics, gene content, and genetic relationships. The objectives include understanding the structure of these genomes, identifying potential gene rearrangements, and providing insights into genetic improvement and conservation strategies for the genus.
Methods: cpDNA sequences from six species were sequenced and analyzed.
Understanding and steering the stability of earth-abundant electrocatalysts in acidic medium is essential for proton exchange membrane (PEM) water electrolyzer. Manganese oxide (MnO) is one of the promising candidates for acidic oxygen evolution reaction (OER), but it still suffers from the overoxidation and the underlying mechanism remains elusive. Here, we observed that lattice oxygen was involved in the OER process on γ-MnO via Mars-van-Krevelen mechanism.
View Article and Find Full Text PDFThe electrocatalytic glycerol oxidation reaction (GOR) represents a mild and sustainable pathway to produce value-added chemicals such as formate. However, the rational design and controlled synthesis of efficient catalysts to achieve highly selective C-C bond cleavage of glycerol towards formate remains a great challenge. Herein, atomic Pd doped CuN hollow nanocubes with Pd-Cu dual sites were prepared via the unique Kirkendall process, exhibiting superior electrocatalytic GOR activity and selectivity towards formate with a maximum Faraday efficiency of 91.
View Article and Find Full Text PDFChimeric antigen receptor (CAR)-T cell therapy represents a promising strategy for cancer treatment. However, the diversity of solid tumor antigens and the poor infiltration of CAR-T cells significantly hinder the efficacy of CAR-T therapies against tumors. Here, a spatially distributed microneedle system (SDMNS) is developed that leverages bioorthogonal reactions to activate and guide endogenous T cells to tumors for effective destruction.
View Article and Find Full Text PDFCatecholamines, as important neurotransmitter and clinical drugs, have a wide range of regulatory roles in physiological activities. The recognition of catecholamine enantiomer (CE) and the elucidation of recognition mechanism are of great significance for the in-depth understanding of biomolecular interactions. This work reveals the molecular recognition mechanism of cyclodextrin (CD) towards CEs through experimental measurements of ion mobility spectrometry (IMS) and theoretical studies including molecular dynamics (MD) simulation and quantum chemical (QC) calculation.
View Article and Find Full Text PDFWe study the transport property through the serially coupled double quantum dots (DQDs) system with Kondo resonance based on the dissipation equation of motion theory. A nonlinear behavior of the transport current is exhibited due to the competition between the interdot coupling strength of the two QDs and the Kondo effect. With the increase in interdot coupling strength, the transport current first increases at low interdot couplings and then decreases with the strong interdot couplings.
View Article and Find Full Text PDFPerovskite quantum dots (PQDs) have garnered significant attention in the display industry as high-performance luminescent materials in recent years. However, in outdoor applications, it is highly challenging to maintain the luminescent performance of PQDs while simultaneously ensuring superhydrophobicity and self-cleaning functionality in rainy weather conditions. Here, we report a luminescent pixel array fabricated using superhydrophobic PQDs with a photoluminescence quantum yield (PLQY) of 32%.
View Article and Find Full Text PDFHighly effective and efficient remediation of hazardous Ni waste from electroless electroplating wastewater remains a significant challenge. However, rather than regarding it as hazardous waste, Ni-electroplating wastewater can instead be considered a huge resource of Ni. Herein, we report a convenient hydrothermal strategy for upcycling Ni from nickel-electroplating wastewater into a carbon-doped Ni-P alloy (denoted as C/Ni-P) electrocatalyst for the oxidation of glycerol to formate.
View Article and Find Full Text PDFETV6::RUNX1 is the most common fusion gene in childhood acute lymphoblastic leukemia (ALL) associated with favorable prognosis, but the optimal therapy for this subtype remains unclear. Profiling the genomic and pharmacological landscape of 194 pediatric ETV6::RUNX1 ALL cases, we uncover two transcriptomic clusters, C1 (61%) and C2 (39%). Compared to C1, the C2 subtype features higher white blood cell counts and younger age at diagnosis, as well as better early treatment responses.
View Article and Find Full Text PDFWe sought to test the hypothesis that adult folate biomarker concentrations are negatively associated with the risk and severity of periodontitis. Data were pooled from the National Health and Nutrition Examination Survey (NHANES) 2009 to 2014. A total of 9252 dentate adult subjects aged 30 years and older who received a periodontal examination and had complete folate biomarker data were included in the analysis.
View Article and Find Full Text PDFBackground: Patients with vertebral compression fractures may experience unpredictable residual pain following vertebral augmentation. Clinical prediction models have shown potential for early prevention and intervention of such residual pain. However, studies focusing on the quality and accuracy of these prediction models are lacking.
View Article and Find Full Text PDFAs the vital the biomacromolecule in eukaryotic cells, tubulin protein is essential for preserving cell shape, facilitating cell division, and cell viability. Tubulin has been approved as promising target for anticancer, and antifungal therapy. However, there are still many gaps in tubulin-targeted fungicidal discovery.
View Article and Find Full Text PDFAcentric crystalline materials are the cornerstone of numerous cutting-edge technologies and have been highly sought-after, but they are difficult to construct controllably. Herein, by introducing a new p-block element to break the symmetrical environment of the d transition metal in the centric matrix TiTeO, a novel acentric tellurite sulfate, namely Ti(TeO)(SO), was successfully constructed. In its structure, two types of p-block element-centered oxo-anionic groups, [TeO] and [SO], endow [TiO] with an out-of-center distortion along the local C[111] direction, which is rare in titanium oxides containing a lone-pair cation.
View Article and Find Full Text PDFBackground: Segmentation of the cochlea in temporal bone computed tomography (CT) is the basis for image-guided otologic surgery. Manual segmentation is time-consuming and laborious.
Purpose: To assess the utility of deep learning analysis in automatic segmentation of the cochleae in temporal bone CT to differentiate abnormal images from normal images.
The direct dehydrogenation of alkanes to olefins under mild conditions is challenging due to the inert nature of alkyl C─H bonds. Herein, an efficient photocatalytic system is developed for propane direct dehydrogenation (PDH) to propylene, consisting of ≈1.30 nm sized PtO clusters immobilized on a layered double hydroxide -derived ZnO/AlO support (LD-Pt).
View Article and Find Full Text PDFPoly(triazine imide) (PTI) materials, a class of layered graphitic carbon nitrides, have garnered significant attention for their unique electronic, thermal, and catalytic properties. These properties can be adjusted through postsynthesis treatments. However, the influence of these treatments on the layer stacking modes and local structures within PTI remains largely unexplored.
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