[Spatial distribution characteristics and influencing factors of eco-environmental quality based on RS and GIS in Shiyang River Basin, China.].

Based on RS and GIS, 11 indexes from three aspects including natural capital, social pressure and economic supports were selected. The natural capital index (NCI), social pressure index (SPI), economic support index (ESI), and environment quality evaluation index (EQEI) were constructed by using spatial principal component analysis, variation coefficient method, and analytic hierarchy process. The spatial distribution characteristics and influencing factor of the environmental quality in Shiyang River Basin were analyzed.

[Preparation and Photoluminescent Properties of Ce³⁺-Activated LaPO₄ Nanocrystals and Core/Shell Structure].

Hydrophobic, monodisperse LaPO₄: Ce³⁺ nanoparticles, LaPO₄:Ce³⁺/LaPO₄ and LaPO₄:Ce³⁺/LaPO₄: Ce³⁺/ LaPO₄ core/shell structure nanocrystals were synthesized via a high-temperature organic solution approach. The as-synthesized samples were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR) and photoluminescence spectroscopy (PL). The results show that: all the samples are a monoclinic phase, Because of the size small nanoparticles, the diffraction peaks of the sample occurs width phenomenon.

Identification of Novel Breast Cancer Subtype-Specific Biomarkers by Integrating Genomics Analysis of DNA Copy Number Aberrations and miRNA-mRNA Dual Expression Profiling.

Breast cancer is a heterogeneous disease with well-defined molecular subtypes. Currently, comparative genomic hybridization arrays (aCGH) techniques have been developed rapidly, and recent evidences in studies of breast cancer suggest that tumors within gene expression subtypes share similar DNA copy number aberrations (CNA) which can be used to further subdivide subtypes. Moreover, subtype-specific miRNA expression profiles are also proposed as novel signatures for breast cancer classification.

Cross talk between vascular smooth muscle cells and monocytes through interleukin-1β/interleukin-18 signaling promotes vein graft thickening.

Objective: Interleukin (IL)-1β and IL-18 are key proinflammatory cytokines that play important roles in the pathophysiology of vein graft remodeling. However, the mechanism of IL-1β/IL-18 production and its role in the development of graft remodeling remain unclear.

Approach And Results: IL-1β/IL-18 were rapidly expressed in venous interposition grafts.

Positive regulation of hepatic miR-122 expression by HNF4α.

Background & Aims: miR-122 is the most abundant microRNA in the liver and regulates metabolic pathways including cholesterol biosynthesis, fatty acid synthesis, and oxidation. However, little is known about mechanisms that regulate the expression of miR-122 in the liver. The aim of this study was to identify key transcriptional regulators for miR-122 expression through intensively studying its primary transcript and promoter region.

Alteration of microRNA expression correlates to fatty acid-mediated insulin resistance in mouse myoblasts.

As new regulators at the post-transcriptional level, microRNAs (miRNAs) are non-coding 19-22 nucleotide RNA molecules that are believed to regulate the expression of thousands of genes. Since the monounsaturated fatty acid oleate can reverse insulin resistance induced by the saturated fatty acid palmitate, we carried out microarray analysis to determine differences in miRNA expression profiles in mouse muscle C2C12 cells that were treated with palmitate and palmitate plus oleate. Among the altered miRNAs, the expression levels of miR-7a, miR-194, miR-337-3p, miR-361, miR-466i, miR-706 and miR-711 were up- or down-regulated by palmitate, but restored to their original level by oleate.

A novel analog of antimicrobial peptide Polybia-MPI, with thioamide bond substitution, exhibits increased therapeutic efficacy against cancer and diminished toxicity in mice.

Polybia-MPI (MPI), a short cationic α-helical antimicrobial peptide, exhibited excellent anticancer activity and selectivity in vitro in our previous studies. To improve its in vivo application, we synthesized an analog (MPI-1) of MPI by replacing the C terminal amide -[CO-NH(2)] with thioamide -ψ[CS-NH(2)]. Although there is just one atom difference, the MPI-1 exhibited some surprising properties.

[Measurement on bone density of children's mandible by quantitative computed tomography].

Objective: To explore the change of bone density of children's mandible measured by quantitative computed tomography (QCT).

Methods: 71 children aged between 10-16 years were measured by QCT in left mandible angle, middle of mandible and right mandible angle. The differences were analyzed according to the age and sex respectively.

Competition between ferromagnetism and antiferromagnetism: origin of large magnetoresistance in polycrystalline SrRu(1-x)Mn(x)O(3) (0≤x≤1).

Polycrystalline SrRu(1-x)Mn(x)O(3) (0≤x≤1) perovskite oxides have been prepared by a conventional solid-state reaction technique. Magnetic and magnetotransport properties are measured using a superconducting quantum interference device (SQUID, Quantum Design MPMS) over a temperature range of 4-300 K. The substitution of Mn ions for Ru drives the system from a ferromagnetic state, SrRuO(3), to an antiferromagnetic state, SrMnO(3), which is basically similar to observations in single-crystal SrRu(1-x)Mn(x)O(3) (Cao et al 2005 Phys.

Insights into mechanism of NMD: digging from the NMD-related protein complexes.

Nonsense-mediated RNA decay (NMD), an mRNA quality control mechanism, triggers degradation of mRNAs that contain premature termination codon (PTC) within their coding regions. NMD is a relatively conservative process that involves many trans-acting factors. The key domains for their function in NMD are conserved in evolution.