The brain targeting efficiency following nasally applied MPEG-PLA nanoparticles in rats.

The aim of this study was to encapsulate nimodipine (NM) within methoxy poly(ethylene glycol)-poly(lactic acid) (MPEG-PLA) nanoparticles and to investigate its brain targeting efficiency following intranasal administration. NM-loaded nanoparticles, prepared through an emulsion/solvent evaporation technique, were characterized in terms of size, zeta potential, NM loading and in vitro release. The nanoparticles were administered intranasally to rats, and the concentrations of NM in blood, cerebrospinal fluid (CSF) and brain tissues were monitored.

Enhancement of systemic and CNS delivery of meptazinol hydrochloride by intranasal administration to rats.

Aim: To investigate the extent of systemic absorption and uptake of meptazinol (MEP) hydrochloride in cerebrospinal fluid (CSF) after intranasal administration on rats and compare with oral administration.

Methods: CSF samples were collected by a serial sampling method. The concentration of MEP in the biological samples was measured by HPLC with fluorescence detector.

Effects of intranasal administration of nimodipine on cerebral hemodynamics of dogs.

Aim: To investigate the effect of nimodipine (NM) on cerebral blood flow (CBF) in dogs following intranasal administration.

Methods: NM solution was administered intranasally, intravenously (i.v.