Publications by authors named "Zhen-lin Liu"
Article Synopsis
- Ulcerative colitis (UC) is an inflammatory bowel disease that may be worsened by cellular senescence, although their relationship is not fully understood.
- New research shows that the compound Tedizolid Phosphate (TED) can combat senescence in colon cells affected by the UC inducer dextran sulfate sodium (DSS).
- TED not only alleviated UC symptoms and colon senescence in mice but also worked by restoring AMPK signaling, suggesting that targeting senescence might be a promising treatment strategy for UC.
Genistein, a potent antioxidant compound, protects dopaminergic neurons in a mouse model of Parkinson's disease. However, the mechanism underlying this action remains unknown. This study investigated human SH-SY5Y cells overexpressing the A53T mutant of α-synuclein.
View Article and Find Full Text PDFThe anti-inflammatory and antioxidant effects of exendin-4 (Ex-4) have been reported previously. However, whether (Ex-4) has anti-inflammatory and antioxidant effects on high-altitude cerebral edema (HACE) remains poorly understood. In this study, two rat models of HACE were established by placing rats in a hypoxic environment with a simulated altitude of either 6000- or 7000-m above sea level (MASL) for 72 hours.
View Article and Find Full Text PDFBackground: Carotid stenosis is one of the common reasons for patients with ischemic stroke, and the two invasive options carotid endarterectomy (CEA) and carotid artery stenting (CAS) are the most popular treatments. But the relative efficacy and safety of the methods are not clear.
Methods: About 521 articles related to CAS and CEA for carotid stenosis published in 1995 - 2011 were retrieved from MEDLINE, Cochrane Library (CL), and China National Knowledge Infrastructure (CNKI) China Journal Full-Test database.
Objective: To explore if folic acid/polyamide-amine (FA/PAMAM) enhances the therapeutic effect of miR-7gene therapy for glioma in vivo.
Methods: The miR-7 gene was transfected into U251 glioma cells by FA/PAMAM. The efficiency of gene transfection was assessed by fluorescence microscopy.
[Ion chromatography for determination of ammonia sampled by silica gel in air of workplace].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
February 2012
Objective: To establish an ion chromatography (IC) method for determination of ammonia in air of workplace.
Methods: Ammonia in workplace air was collected in silica gel tube, desorbed with 10 mmol/L methanesulfonic acid by ultrasonic for 10 min, determined by IC.
Results: The linearity range was 0.
Objective: To explore the role and function of stromal cell-derived factor-1 (SDF-1) in stem cells migrating into injured brain area.
Methods: Rat-derived nerve stem cells (NSCs) were isolated and cultured routinely. Transwell system was used to observe the migration ability of NSCs into injured nerve cells.
Objective: To promote stem cells differentiation into neurons and enhance neuromotor function after brain injury through brain-derived neurotrophic factor (BDNF) induction.
Methods: Recombinant adenovirus vector was applied to the transfection of BDNF into human-derived umbilical cord mesenchymal stem cells (UCMSCs). Enzyme linked immunosorbent assay (ELISA) was used to determine the secretion phase of BDNF.