Publications by authors named "Zhen-hai Zhou"
Background: Adolescent idiopathic scoliosis (AIS) is common deformity with unknown cause. Previous studies have suggested the abnormal serum leptin and ghrelin level in AIS girls. The aim of present study was to evaluate whether the serum leptin and ghrelin level could serve as risk factor in predicting the curve progression in AIS girls.
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- The study was a retrospective analysis aiming to evaluate the outcomes of different surgical approaches (posterior only, anterior only, and combined) for treating adults with thoracic tuberculosis over a minimum of five years.
- A total of 184 patient records were analyzed, revealing that the posterior-only approach had significantly lower operative time, blood loss, and complications compared to the other methods, while also achieving good correction rates.
- The findings suggest that the anterior-only approach should be used sparingly, as the combined anterior and posterior approach, although adequate, involves more trauma than the posterior-only method.
Article Synopsis
- The study investigates why primary chondrocytes from girls with adolescent idiopathic scoliosis (AIS) have low metabolic activity and how this relates to leptin signaling, which is crucial for bone growth and chondrocyte function.
- AIS patients showed similar serum leptin levels to controls but had reduced phosphorylation of JAK2 and STAT3, along with lower cartilage matrix synthesis and Ob-R expression on their cell membranes.
- Researchers found that inhibiting lysosomes increased total Ob-R but did not impact its membrane expression, while knocking down clathrin heavy chain (CHC) improved membrane Ob-R levels and boosted the effects of leptin, suggesting the dysfunction stems from the balance of Ob-R endocytosis and new receptor synthesis
Article Synopsis
- The study compares outcomes of two surgical techniques (anterior-posterior vs. posterior-only) for treating thoracolumbar tuberculosis in children aged 5 to 14 years from 2005 to 2009.
- A retrospective review of 47 children reveals that the posterior approach resulted in shorter operative time, less blood loss, and fewer complications compared to the anterior-posterior method, while both approaches effectively treated the disease.
- The findings suggest that the posterior approach may be preferable, especially for children with poorer health or early stages of bone destruction.
Purpose: We present a retrospective study of patients with multilevel contiguous tuberculous spondylitis of thoracic region that underwent single-stage posterolateral debridement and fusion and following posterior instrumentation.
Methods: From June 2000 to March 2009, 870 consecutive spinal tubercular patients including 36 patients who were diagnosed and treated as multilevel contiguous thoracic spinal tuberculosis in our institution. Apart from five patients being treated conservatively, the 31 cases received surgery by single-stage posterolateral debridement, fusion, following posterior instrumentation and postural drainage.
[Distribution and activation of dendritic cells in immune thrombocytopenia patients].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2013
Defective dendritic cell (DC) functions have been implicated in ITP. The purpose of this study was to investigate the distribution and activation of dendritic cells in immune thrombocytopenia (ITP) patients. ITP patients were divided into 3 groups: the newly diagnosed, refractory and effective treatment group.
View Article and Find Full Text PDF[BAFF level in bone marrow and expression of BAFF receptor on B cells in multiple myeloma patients].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
October 2012
This study was purposed to investigate the B cell-activating factor belonging to the TNF family (BAFF) and a proliferation-inducing ligand (APRIL) levels in bone marrow, and the BAFF receptor expression level on B cells in multiple myeloma (MM) patients, in order to explore the characteristics of B cells in bone marrow of MM patients. MM patients were studied before treatment (newly diagnosed group, 19 patients) and after treatment with improvement (stable group, 17 patients), 10 non-hematologic patients were selected as control (control group). The BAFF receptors (BAFF-R) and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) on B cell (CD19(+)), naive B cell (CD19(+)IgD(+)) and memory B cell (CD19(+)CD27(+)) of bone marrow in all groups were detected by flow cytometry.
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- The study aimed to examine the rate of HIV sero-conversion among men who have sex with men (MSM) in Beijing and identify related risk factors.
- A cohort of 809 sero-negative MSM was monitored over 18 months, with follow-ups revealing varying HIV incidence rates: 5.47, 12.37, and 6.86 per 100 person-years at 6, 12, and 18 months, respectively.
- Key risk factors for increased HIV incidence included being younger than 25, having multiple partners, lower income, and certain health conditions, highlighting the need for enhanced prevention strategies in this demographic.
[Incidence and risk factors of HIV and syphilis seroconversion among men who have sex with men in Beijing].
Zhonghua Yu Fang Yi Xue Za Zhi
February 2011
Objective: To study the incidence and risk factors of HIV and syphilis seroconversion among men who have sex with men (MSM) in Beijing.
Methods: A total of 550 MSM were recruited on the basis of community and followed up after 6 and 12 months in Beijing. Each subject was investigated by only one investigator at one time to collect information on demographics and behaviors.
Objective: To explore the clinical features of infection in multiple myeloma (MM) undergoing autologous hematopoietic stem cell transplantation (ASCT).
Methods: Thirty-seven patients with MM undergoing ASCT were retrospectively analyzed for type and time of infection, pathogen, and outcome.
Results: Fifty-nine cases of infectious complications occurred in 33 patients (89.
[Correlation of CD19 positive cell counts in bone marrow with therapeutic efficacy in patients with multiple myeloma].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
February 2011
This study was aimed to analyze the correlation of CD19 positive cell counts in bone marrow of multiple myeloma(MM) patients with therapeutic efficacy and investigate the characteristics of CD19 cell change in MM bone marrow. The CD19(+) and CD38(++)CD45(-), CD38(++)CD45(-)CD56(+) cells in bone marrow of 63 MM patients were detected by flow cytometry. The difference of CD19(+), CD38(++)CD45(-), CD38(++)CD45(-)CD56(+) cell counts at different stages and types, as well as their relation with results of 4 course of VADM or VD chemotherapy were analyzed.
View Article and Find Full Text PDFObjective: To explore the characteristics of B cell-activating factor (BAFF) secreted by peripheral blood monocyte-derived dendritic cell (MoDC) in chronic idiopathic thrombocytopenic purpura (cITP) and the function of MoDC on B cell proliferation.
Methods: Ten cITP patients were studied dynamically before and after treatment. The BAFF levels in serum and the supernatant of LPS stimulated MoDC were tested with ELISA.
Objective: To study the prevalence and risk factors of human immunodeficiency virus (HIV) among men who have sex with men (MSM) in Beijing.
Methods: A sample of 550 MSM was recruited between March and June in 2008 in Beijing. Interviewer-administered interviews were conducted to collect information on demographics and behaviors.
Background And Objective: Vascular endothelial growth factor (VEGF) is the most important angiogenic factor of multiple myeloma (MM). This study was to investigate the effect of transfection of human soluble vascular endothelial growth factor receptor-1 (sFlt-1) gene on the proliferation of human MM cell line RPMI8226.
Methods: The recombinant plasmid pcDNA3-sFlt-1 was constructed and transfected into RPMI8226 cells.
Objective: Bence Jones protein (BJP) plays an important role in multiple myeloma (MM) renal lesion, we try to study the relation between the characteristics of BJP variable gene and the function of renal tubular-epithelial cell (TEC).
Methods: MM patients whose function of TEC was abnormal at diagnosis constituted a group damage and patients whose function of TEC was normal for a long period a group normal. We also collected MM patients and divided them into a group BJPkappa and a group BJPlambda.
Background & Objective: More and more studies indicated that microenvironment plays a major role in growth, survival, and drug resistance of myeloma cells. Thalidomide is one of agents targeting the bone marrow microenvironment. This study was conducted to investigate the mechanism of thalidomide by observation of influence of thalidomide on bone marrow microenvironment in refractory and relapsed multiple myeloma.
View Article and Find Full Text PDFBackground & Objectives: The efficiency of rituximab (Mabthera) is related to CD20 expression density on cell membrane. It is not yet to be solved how to heighten expression level of CD20 on multiple myeloma (MM) cell membrane and to increase the efficacy of Mabthera to MM. This study was designed to observe whether thalidomide could promote the effect of Mabthera on suppressing myeloma cells in vitro and its possible mechanism.
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