Publications by authors named "Zhen-cheng Yan"
Article Synopsis
- This study examines the relationship between metabolic syndrome and chronic venous disorders in the lower extremities, particularly focusing on how cardiometabolic risk factors affect this condition.* -
- It finds that women are more likely to develop early chronic venous disorder compared to men, and highlights specific risk factors such as higher blood pressure in men and elevated fasting glucose levels in women.* -
- Diabetic patients with early chronic venous disorder show worse outcomes in terms of blood sugar levels and macrovascular complications, with age and fasting plasma glucose identified as key independent risk factors for women.*
[Evaluation of visceral adipose in abdominal obesity and its clinical application].
Zhonghua Yi Xue Za Zhi
September 2008
Objective: To compare the values of measurements of obesity, including body mass index(BMI), waist circumference (WC), waist-to-hip ratio (WHR), bioelectrical impedance analyzer(BIA) (fat mass and FAT%), ultrasonography (US) (subcutaneous fat distance and intraabdominal fat distance), and computed tomography (CT) in predicting the quantification of visceral adipose in abdominal obesity, and to evaluate the best cut-off point, sensitivity and specificity of these methods.
Methods: 4,301 inpatients with hypertension, 2,155 males and 2,146 females, aged (56.4 +/- 13.
Objective: To explore the relationship of different types of abdominal obesity to risk of metabolic syndrome (MS).
Methods: Visceral fat area (VA) and substantial fat area (SA) were assessed by CT in 846 patients, 470 males and 376 females, aged 55 +/- 12, who suffered from at least one cardiometabolic risk factor and divided into 4 groups according to their VA and waist circumference (WC): non-obesity, masked visceral fat obesity (VFO), pseudo-VFO, and VFO groups. Blood pressure, fasting blood glucose, fasting serum insulin, and lipid profile were also measured.
[Relationship between abdominal obesity and left ventricular weight/function].
Zhonghua Xin Xue Guan Bing Za Zhi
February 2007
Objective: To observe the relationship between abdominal obesity and left ventricular weight/function.
Methods: A total of 495 patients [265 males, mean age (55 +/- 12) years] with hypertension (139), diabetes (65), metabolic syndrome (285), diabetes complicated with hypertension (11) were enrolled in this study. Visceral adipose area (VA), the subcutaneous adipose (SA), the total abdominal adipose (TA) were measured by computerized tomography (CT) and left ventricular weight and function were obtained by echocardiography.
We tested the hypothesis that activation of transient receptor potential vanilloid type-1 (TRPV1) by capsaicin prevents adipogenesis. TRPV1 channels in 3T3-L1-preadipocytes and visceral adipose tissue from mice and humans were detected by immunoblotting and quantitative real-time RT-PCR. The effect of TRPV1 on cytosolic calcium was determined fluorometrically in 3T3-L1-preadipocytes and in human visceral fat tissue.
View Article and Find Full Text PDFObesity is one major cardiovascular risk factor. We tested effects of endurance exercise on cannabinoid receptor type 1 (CB1) and peroxisome proliferator-activated receptor-delta (PPAR-delta)-dependent pathways in adipose tissue. Male Wistar rats were randomly assigned to standard laboratory chow or a high-fat diet without and with regular endurance exercise.
View Article and Find Full Text PDFObjective: To investigate the relationship between PPARdelta + 294T/C gene polymorphism and lipid profile, obesity and left ventricular hypertrophy (LVH) in patients with metabolic syndrome (MS).
Methods: This study was conducted in 300 patients with MS and 174 patients with essential hypertension (EH) and 143 patients with type 2 diabetes mellitus (T2DM). MS was diagnosed according to 1999 WHO criteria.
Objective: To assess the relationship between PPAR gamma C161-T polymorphism and Carotid Atherosclerosis in metabolic Syndrome (MS).
Methods: Polymerase chain reaction-restricted fragments length polymorphism was used to study the distribution of the PPAR gamma C161-T polymorphism in 248 metabolism syndrome, 163 essential hypertension (EH) and 115 type 2 diabetes mellitus (DM) patients and 121 normal controls. Fasting insulin (FINS), fasting blood glucose (FBG), uric Acid (UA), plasma lipids and ultrasonography for carotid artery were examined.