Publications by authors named "Zhen-Zheng Wang"
Article Synopsis
- Cytochrome P450 (CYP) 3A4 is crucial for metabolizing corticosteroids, and the study investigates how the herbal remedy epimedium affects this enzyme and its interaction with corticosteroids.
- Epimedium was found to inhibit CYP3A4 activity in a dose-dependent manner and reduced CYP3A4 mRNA expression, while dexamethasone increased its expression but was suppressed by epimedium.
- The active compound kaempferol from epimedium showed significant inhibition of pro-inflammatory cytokines, IL-8 and TNF-α, enhancing anti-inflammatory effects while also inhibiting CYP3A4 activity.
Objective: To investigate the clinicopathological characteristics, diagnosis and differential diagnosis, and treatment of xeroderma pigmentosum associated with keratoacanthoma in an infant.
Methods: The clinical manifestations of xeroderma pigmentosum associated with keratoacanthoma were assessed in an 18-month old boy. The morphological and histological features of the lesions were examined by light microscopy.
[Clinical and pathological features of adult patients with acquired rubella].
Zhonghua Gan Zang Bing Za Zhi
July 2009
Objective: To explore the clinical and pathological features of liver injury in adults with acquired rubella.
Methods: Thirty-six adult patients with acquired rubella (AAR) were enrolled in this study, the liver functions were dynamically analyzed, liver biopsy was done in two patients.
Results: Liver injury was found in 77.