Publications by authors named "Zhen-Zhen Wang"
Article Synopsis
- - Berberine (BBR), a small molecule, effectively inhibits HIV infection in cervical cancer cells (specifically HeLa-derived TZM-bl cells) by blocking key viral processes like HIV RNA expression and reverse transcriptase secretion.
- - BBR not only reduces HIV-induced cancer cell viability and clustering but also prevents migration and invasion of infected cervical cancer cells, suggesting it may help control the progression of both cervical cancer and HIV.
- - Molecular studies reveal that BBR interacts with HIV Tat protein, pointing to its potential as a therapeutic agent against HIV infection and its associated cervical cancer complications.
Article Synopsis
- Pulmonary sarcomatoid carcinoma (PSC) is a rare and challenging subtype of non-small cell lung cancer that complicates diagnosis and treatment.
- A case study of a male patient with advanced PSC showed high PD-L1 levels, suggesting he might benefit from immune checkpoint inhibitors, but his cancer progressed quickly despite treatment.
- Following progression, the combination of tislelizumab and anlotinib resulted in near-partial remission; however, the patient ultimately suffered from fatal hemoptysis, highlighting the importance of monitoring for this serious complication in similar cases.
Article Synopsis
- Collagenases are enzymes that break down collagen and are important for tissue repair and medical treatments; this review explores their variety, structure, and mechanisms.
- It discusses the critical biochemical properties of collagen and how collagenases are sourced, especially from microbes, with applications in tissue engineering and food processing.
- The review also covers methods for measuring collagenase activity for research and clinical purposes, while highlighting future research opportunities for using collagenases to enhance wound healing and address issues like scar tissue and fibrosis.
Article Synopsis
- Food allergies affect nearly 30 million people in the U.S., and managing them primarily involves avoiding allergens due to limited treatment options; this study explores the small molecule compound formononetin as a potential therapeutic alternative.* -
- The study findings reveal that formononetin significantly reduces IgE production and prevents mast cell degranulation in laboratory tests, indicating its potential effectiveness in treating food allergies.* -
- Formononetin impacts multiple targets related to food allergies and other diseases, and pathway analyses suggest it might influence processes involving B cell proliferation, primary immunodeficiency, and cancer pathways.*
Article Synopsis
- The study focused on the fungus Stereum hirsutum, leading to the extraction of 12 isopentenyl benzene derivatives, including six new compounds named stereuins A-F.
- The structures of these compounds were confirmed using NMR and mass spectrometry, with stereuins A-C being benzoate derivatives that include fatty acid components.
- Stereuin A showed potential for promoting nerve cell growth in vitro, while compounds D-F demonstrated antibacterial properties against Staphylococcus aureus, with stereuin F being nearly as effective as penicillin G.
Article Synopsis
- - The article discusses heat stress (HS) in mammals, which disrupts their thermal balance and negatively impacts the development of oocytes and embryos, resulting in economic losses in the livestock industry.
- - It outlines the mechanisms by which HS affects embryonic development, including the generation of reactive oxygen species, endocrine disruption, and molecular changes.
- - The article also explores strategies to mitigate HS effects, such as using antioxidants, enhancing mitochondrial function, gene editing, and improving the animals' rearing environment.
Article Synopsis
- Carboxylesterase 1 (CES1) is an enzyme that plays a key role in metabolizing various substances in mammals, and its inhibition could help in treating metabolic disorders like obesity and fatty liver disease.
- The study aimed to identify effective inhibitors of CES1 from synthetic pyrazolones, finding that compounds 25, 26, and 27 showed varying types of inhibition against CES1 in lab tests.
- These compounds also demonstrated the ability to prevent fat accumulation in mouse adipose cells, suggesting their potential for developing treatments for hyperlipidemia and related conditions.
Article Synopsis
- The study investigates the effect of Ganoderic Acid C1 (GAC1), a compound from a traditional Chinese medicine formula (ASHMI), on severe, steroid-resistant asthma characterized by high levels of neutrophils in a mouse model.
- Results indicated that GAC1 significantly reduced airway inflammation and neutrophil levels, while also lowering specific cytokines associated with inflammation.
- Additionally, GAC1 demonstrated potential in reducing harmful cell responses in human lung cells, and computational analysis suggested its strong binding to TNF-α, indicating a mechanism for its therapeutic effects in asthma management.
Article Synopsis
- Endoscopy is crucial for detecting esophageal squamous cell carcinoma and precancerous lesions, but improving detection rates is still a challenge.
- A new system using deep convolutional neural networks (CNNs) was developed and tested to enhance the detection of high-risk esophageal lesions (HrELs) during endoscopy, and showed significant improvement in detection rates.
- In a clinical trial with over 3,100 patients, the CNN-assisted endoscopy group had a HrEL detection rate of 1.8%, compared to 0.9% in the control group, demonstrating greater sensitivity, specificity, and accuracy without any adverse events.
Article Synopsis
- - Depression is a common chronic mental illness that varies in response to stress among individuals, with some showing resilience while others display negative psychological effects, possibly linked to molecular mechanisms involving connexin 43 (Cx43) in the brain.
- - Dysfunction of Cx43 in the prefrontal cortex (PFC) is associated with depressive behaviors, and stress exposure notably reduces Cx43 protein levels in susceptible mice but not in resilient ones, as observed in behavioral tests.
- - The study indicates that inflammation is prevalent in central nervous system dysfunction and suggests that understanding the role of Cx43 and inflammatory signals may help develop therapeutic strategies to enhance resilience against stress-related disorders.
Article Synopsis
- * The structures of these compounds were determined using advanced spectroscopic methods, including NMR and mass spectrometry.
- * The new compounds demonstrated significant inhibitory effects on HepG2 cancer cells, with IC values comparable to the positive control cisplatin, indicating potential for cancer treatment.
Article Synopsis
- * Within 48 hours, the transplanted tissue develops its own blood supply and forms thyroid follicles similar to a natural gland, integrating well with surrounding splenic tissue.
- * This method not only successfully restores hormone regulation but also performs better than traditional levothyroxine therapy, offering new possibilities for treating thyroid disorders.
Article Synopsis
- Kai-Xin-San (KXS), a traditional Chinese herbal remedy, is commonly used to treat depression through various mechanisms.
- A systematic study was conducted to evaluate the effectiveness and safety of KXS in animal models of depression, reviewing literature up to June 2022.
- The findings from 24 studies involving 608 animals revealed that KXS significantly improved depressive-like behaviors in tested animals, suggesting its potential as a treatment for depression.
Article Synopsis
- * Advanced techniques like IR, NMR, and ECD calculations were used to determine the structures of these compounds.
- * The compounds were tested for their effects on cancer cell growth, revealing that some, particularly compounds 7 and 15, had strong inhibitory effects on A549 cells, while others showed varying levels of activity against H1299 and HepG2 cancer cells.
TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways.
Hepatobiliary Pancreat Dis Int
April 2024
Article Synopsis
- - The study investigates the role of γ-tubulin (TuBG1) in hepatocellular cancer (HCC) and its association with clinical parameters and patient survival, using bioinformatics and experimental methods to analyze and validate findings.
- - Researchers found that TuBG1 is highly expressed in HCC tissues, and silencing its expression led to inhibited cell proliferation and invasion, and increased apoptosis, indicating its potential as a therapeutic target.
- - An immune prognosis model based on TuBG1-related immune genes was developed, showing that higher TuBG1 levels correlate with poorer overall survival in HCC patients, which may help in evaluating patient prognosis.
Overview and Current Advances in Dapsone Hypersensitivity Syndrome.
Curr Allergy Asthma Rep
November 2023
Article Synopsis
- Dapsone is an antibacterial agent primarily used to treat leprosy and has anti-inflammatory effects that make it suitable for various immune diseases, but it can cause serious side effects, particularly dapsone hypersensitivity syndrome.
- This syndrome is marked by a combination of skin eruptions, fever, and organ issues, which limits the drug's use.
- Recent research explores the genetic and immune factors contributing to dapsone hypersensitivity, aiming to improve diagnosis, prevention, and treatment for affected patients.
Article Synopsis
- Research indicates that IFN-λ has tumor-suppressive roles but also exhibits potential tumor-promoting effects, especially in certain cancer types.
- A comprehensive analysis showed that higher endogenous IFN-λ expression correlates with poor prognosis in cancer patients, identifying genes like IFN-λ2 and IFN-λ3 as independent prognostic markers.
- The study found that while IFN-λ influences immune cell infiltration and modifies immune checkpoints, this does not enhance survival, likely due to T-cell dysfunction and an inflammatory environment in tumors.
Article Synopsis
- * There is an urgent need for cost-effective and accurate methods for early GC detection, with DNA methylation showing promise as a potential marker for this purpose.
- * Most existing DNA methylation markers for GC are still in the early discovery phase, primarily tested on tissue samples. Future research should focus on identifying GC-specific markers and developing non-invasive diagnostic assays validated across diverse populations.
[Inhibitory Effect of Resveratrol on the Proliferation of Multiple Myeloma Cells and the Underlying Mechanism].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
August 2023
Article Synopsis
- * RSV treatment resulted in reduced MM cell proliferation and increased apoptosis in a time- and dose-dependent manner.
- * The study found that RSV inhibits the expression of miR-21, leading to cell cycle alterations and promoting apoptosis, suggesting it could be a potential therapeutic agent for MM.
Article Synopsis
- Eight new lanostane triterpenoids and nine previously known ones were discovered in the fruiting bodies of *Ganoderma lingzhi*, with their structures determined using spectroscopy and quantum chemical methods.
- The compound ganoderane GL-1 is notable for being the first identified member of the lanostane nor-triterpenoid group, containing a unique hydrogenated tetramethyls-phenanthraquinone structure.
- Biologically, ganoderanes GL-2 and GL-3 show effective inhibition of nitric oxide production in macrophage cells, while ganoderanes GL-4 and GL-8 demonstrate both anti-proliferative and anti-inflammatory properties.
Article Synopsis
- Connexin 43 (Cx43) is primarily found in mammals, particularly in the cardiovascular and nervous systems, and its function is heavily influenced by phosphorylation, which is regulated by multiple kinases and phosphatases.
- The phosphorylation status of Cx43 alters its synthesis, assembly, and functionality of gap junctions (GJs), impacting important cellular functions like permeability and intercellular communication.
- The review highlights Cx43's role in various diseases and proposes it as a potential drug target for improving outcomes in cardiac and neurological protection.