Zimberelimab plus chemotherapy as the first-line treatment of malignant peritoneal mesothelioma: A case report and review of literature.

Background: Malignant peritoneal mesothelioma (MPeM) is a rare cancer with a poor prognosis at advanced stage, and the standard first-line treatment for inoperable patients is chemotherapy. Although combining programmed cell death 1 (PD-1) inhibitors with chemotherapy is generally considered safe and effective in several malignant solid tumors, there are few reports regarding initial immunochemotherapy in advanced MPeM.

Case Summary: Here, to our knowledge, we present the first case of a patient with epithelioid subtype MPeM, who was treatment-naïve and benefited from initial PD-1 inhibitor plus standard chemotherapy with a prolonged progression-free survival (PFS) and good tolerance.

Spectral analyses of Dy/Sr: LaF and Dy/Ca: LaF mixed crystals for laser applications.

Mixed crystals of Dy/Sr: LaF and Dy/Ca: LaF were grown by Bridgman technique and their spectral properties were investigated. Spectra broadening and peak shifts were observed, indicating the co-doping of Sr/Ca brings about a more disordered local symmetry of Dy, which makes both crystals favorable for tunable lasing action. Low-temperature high resolution excitation and emission spectra were carried out for exploring the types of luminescent center of Dy in crystals.

Ultrasensitive nonlinear absorption response of large-size topological insulator and application in low-threshold bulk pulsed lasers.

Dirac-like topological insulators have attracted strong interest in optoelectronic application because of their unusual and startling properties. Here we report for the first time that the pure topological insulator Bi2Te3 exhibited a naturally ultrasensitive nonlinear absorption response to photoexcitation. The Bi2Te3 sheets with lateral size up to a few micrometers showed extremely low saturation absorption intensities of only 1.

Analyzing the differentially expressed genes and pathway cross-talk in aggressive breast cancer.

Aim: The aim of this study was to explore the genes and pathways involved in the aggressive breast cancer cells.

Methods: The gene expression profiles of GSE40057, including four aggressive breast cell lines and six less aggressive cell lines, were downloaded from the Gene Expression Omnibus (GEO) database. The gene differential expression analysis was carried out with limma software with the method of Bayes for multiple tests.

Self-Q-switched, orthogonally polarized, dual-wavelength laser using long-lifetime Yb³⁺ crystal as both gain medium and saturable absorber.

A novel self-Q-switched and orthogonally polarized dual-wavelength laser has been investigated with Yb³⁺-doped CGB disordered crystals. By slightly inclining output coupler to introduce the Fresnel loss, we realized simultaneously dual-wavelength laser operation at 1052.6 nm in E//b polarization and 1057.

Radiosensitivity of prostate cancer cells is enhanced by EGFR inhibitor C225.

Purpose: To determine the direct effects of the epidermal growth factor receptor (EGFR) inhibitor C225 on the radiosensitivity of human prostate cancer cells.

Experimental Design: Human prostate cancer DU145 cells were irradiated with (60)Co (1.953 Gy/min) at various doses in the presence or absence of C225.

[Study on the growth and spectral characteristics of LiNbO3:Cr:ZnO crystal].

The LiNbO3:Cr:ZnO crystals with the size up to phi20 mm x 50 mm were grown by the Czochralski technique. The absorption spectrum shows that there are two strong absorption wideband peaks and one weak absorption peak of to Cr3+ ion in the crystal. The peak values of the two strong absorption wideband peaks are 480 and 660 nm, which correspond to 4A2-->4 T1 and 4A2-->4 T2 transitions, respectively.

[Study on the growth and spectral characteristics of Cr3+: Al2 (WO4)3 crystal].

Cr3+:Al2(WO4)3 Crystal was grown from the Na2WO4 solvent system by using the TSSG method. The absorption spectrum shows that there are two strong absorption wideband peaks and one we ak absorption peak belonging to Cr3+ ion in the crystal. The peak values of two strong absorption wideband peaks are at 422 and 595 nm, respectively.