Publications by authors named "Zhen-Yu Wu"

The development of advanced catalysts frequently employs trial-and-error methods and is lack of highly controlled synthesis, resulting in unsatisfactory development efficiency and performance. Here we propose a data-driven prediction coupled with precise synthesis strategy to accelerate the development of single-atom catalysts (SACs) for efficient water purification. The data-driven approach enables the rapid screening and prediction of high-performance SACs from 43 metals-N structures comprising transition and main group metal elements, followed by validation and structural modulation for improved performance through a highly controllable hard-template method.

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Ammonia (NH) is widely recognized as a crucial raw material for nitrogen-based fertilizer production and eco-friendly hydrogen-rich fuels. Currently, the Haber-Bosch process still dominates the worldwide industrial NH production, which consumes substantial energy and contributes to enormous CO emission. As an alternative NH synthesis route, electrocatalytic reduction of NO species (NO , NO , and NO) to NH has gained considerable attention due to its advantages such as flexibility, low power consumption, sustainability, and environmental friendliness.

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Radiotherapy resistance is the main cause of treatment failure among patients with nasopharyngeal carcinoma (NPC). Recently, increasing evidence has linked the presence of intratumoral Fusobacterium nucleatum (Fn) with the malignant progression and therapeutic resistance of multiple tumor types, but its influence on NPC has remained largely unknown. We found that Fn is prevalent in the tumor tissue of patients with NPC and is associated with radioresistance.

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Converting solar energy into fuels is pursued as an attractive route to reduce dependence on fossil fuel. In this context, photothermal catalysis is a very promising approach through converting photons into heat to drive catalytic reactions. There are mainly three key factors that govern the photothermal catalysis performance: maximized solar absorption, minimized thermal emission and excellent catalytic property of catalyst.

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The oxygen evolution reaction (OER) performance of ruthenium-based oxides strongly correlates with the electronic structures of Ru. However, the widely adopted monometal doping method unidirectionally regulates only the electronic structures, often failing to balance the activity and stability. Here, we propose an "elastic electron transfer" strategy to achieve bidirectional optimization of the electronic structures of Sr, Cr codoped RuO catalysts for acidic OER.

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Background: Pegylated liposomal doxorubicin (PLD) is a liposome-encapsulated form of doxorubicin with equivalent efficacy and less cardiotoxicity. This phase 2 study evaluated the efficacy and safety of the PLD-containing CHOP regimen in newly diagnosed patients with aggressive peripheral T-cell lymphomas (PTCL).

Methods: Patients received PLD, cyclophosphamide, vincristine/vindesine, plus prednisone every 3 weeks for up to 6 cycles.

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Colorectal cancer (CRC) remains a significant global health concern, as characterized by its high mortality rate ranking second among all the leading causes of death. The liver serves as the primary site of CRC metastasis, and the occurrence of liver metastasis is a significant contributor to mortality among patients diagnosed with CRC. The survival rate of patients with colorectal liver metastasis has significantly increased with the advancement of comprehensive tumor therapy.

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Background: Upper gastrointestinal neoplasia mainly includes esophageal cancer and gastric cancer, both of which have high morbidity and mortality. Lymph node metastasis (LNM), as the most common metastasis mode of both diseases, is an important factor affecting tumor stage, treatment strategy and clinical prognosis. As a new fusion technology, endoscopic ultrasound (EUS) is becoming increasingly used in the diagnosis and treatment of digestive system diseases, but its use in detecting LNM in clinical practice remains limited.

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Oxytocin (OXT) is secreted in a large amount during the middle and late pregnancy. Except for the regulation of functions related to childbirth, OXT is involved in the regulation of cognition, social behavior, addiction, pain and so on. Our aim is to confirm the increase of OXT content in mice in late pregnancy is the main cause of itch during pregnancy and observe whether exogenously administered OXT can induce or increase itch sensitivity.

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Electrochemical carbon-capture technologies, with renewable electricity as the energy input, are promising for carbon management but still suffer from low capture rates, oxygen sensitivity or system complexity. Here we demonstrate a continuous electrochemical carbon-capture design by coupling oxygen/water (O/HO) redox couple with a modular solid-electrolyte reactor. By performing oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) redox electrolysis, our device can efficiently absorb dilute carbon dioxide (CO) molecules at the high-alkaline cathode-membrane interface to form carbonate ions, followed by a neutralization process through the proton flux from the anode to continuously output a high-purity (>99%) CO stream from the middle solid-electrolyte layer.

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Background/aims: The involvement of long noncoding RNAs in the carcinogenesis of hepatocellular carcinoma (HCC) has been well documented by substantial evidence. However, whether cytoskeleton regulator RNA (CYTOR) could affect the progression of HCC remains unclear.

Methods: The relative expression of CYTOR, miR-125a-5p and HS1-associated protein X-1 (HAX-1) mRNA in HCC cells were determined via quantitative real-time polymerase chain reaction.

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Article Synopsis
  • - Iridium-based catalysts are currently the best option for proton exchange membrane (PEM) water electrolysis but are expensive and scarce, leading researchers to seek alternatives.
  • - The study introduces a nickel-stabilized ruthenium dioxide (Ni-RuO) catalyst, which shows significantly improved activity and durability compared to traditional RuO in acidic environments.
  • - With over 1,000 hours of stability during operation, the Ni-RuO catalyst has potential for practical use in PEM water electrolysis and its effectiveness is supported by advanced theoretical and experimental analyses.
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Background: Under the condition of stress, the hypothalamic-pituitary-adrenal axis (HPA axis) is activated and causes the secretion of corticotropin-releasing factor (CRF). Previous studies have demonstrated that CRF is involved in the regulation of pain and itch. Thus, it remains worthy to explore whether the desensitization of pain and itch under high-intensity acute stress (such as high fear and tension) is related to the sharp increase of CRF.

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Article Synopsis
  • An increasing number of reports suggest a link between breast implants, especially textured ones, and a rare form of lymphoma, raising concerns about their safety.
  • A study reviewed outcomes of 590 breast cancer patients who received either smooth or textured implants and matched 138 to 276 patients for comparison.
  • Results showed no significant differences in recurrence rates or survival outcomes between the two groups, indicating that both types of implants may have similar safety profiles regarding cancer recurrence.
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Background: Cholecystitis with incarcerated gallstones (CIG) is a type of acute abdomen in the field of hepatobiliary surgery. Whether gallbladder-preserving surgery (GPS) can be performed to treat it, however, depends on the improvement of gallbladder contractile function. The present study aimed to investigate the changes in gallbladder contractile function and its influencing factors after minimally invasive GPS for CIG.

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Electro-catalyzed oxygen reduction reaction (ORR), as the positive electrode reaction, is significant to the performance of fuel cells and metal-air batteries. Toward ORR, ultra-small Pt@Mn core-shell nanoparticles catalysts supported on Ketjen black are synthesized by a simple one-pot hydrothermal method. TEM results show that the Pt@Mn/C nanoparticles with an average size of 3∼4 nm are uniformly distributed on the carbon surface.

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Article Synopsis
  • The study investigates whether smoking is an independent risk factor for postoperative cognitive impairment in patients undergoing general anesthesia.
  • It involved 112 patients undergoing painless gastroscopy where baseline cognitive scores were measured, and changes were observed immediately after anesthesia and three days post-op.
  • Results showed significant cognitive differences immediately after anesthesia between smokers and non-smokers, with smoking linked to increased postoperative cough and potentially contributing to cognitive dysfunction in early postoperative recovery.
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Electrochemical oxygen reduction to hydrogen peroxide (HO) in acidic media, especially in proton exchange membrane (PEM) electrode assembly reactors, suffers from low selectivity and the lack of low-cost catalysts. Here we present a cation-regulated interfacial engineering approach to promote the HO selectivity (over 80%) under industrial-relevant generation rates (over 400 mA cm) in strong acidic media using just carbon black catalyst and a small number of alkali metal cations, representing a 25-fold improvement compared to that without cation additives. Our density functional theory simulation suggests a "shielding effect" of alkali metal cations which squeeze away the catalyst/electrolyte interfacial protons and thus prevent further reduction of generated HO to water.

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Electrochemical water oxidation reaction (WOR) to hydrogen peroxide (HO) via a 2e pathway provides a sustainable HO synthetic route, but is challenged by the traditional 4e counterpart of oxygen evolution. Here we report a CO/carbonate mediation approach to steering the WOR pathway from 4e to 2e. Using fluorine-doped tin oxide electrode in carbonate solutions, we achieved high HO selectivity of up to 87%, and delivered unprecedented HO partial currents of up to 1.

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Electrochemically converting nitrate ions, a widely distributed nitrogen source in industrial wastewater and polluted groundwater, into ammonia represents a sustainable route for both wastewater treatment and ammonia generation. However, it is currently hindered by low catalytic activities, especially under low nitrate concentrations. Here we report a high-performance Ru-dispersed Cu nanowire catalyst that delivers an industrial-relevant nitrate reduction current of 1 A cm while maintaining a high NH Faradaic efficiency of 93%.

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Article Synopsis
  • * Out of 1,696 patients reviewed, 128 had local recurrence; 21 of these (16%) experienced some form of reconstruction loss, with rates higher for autologous reconstructions compared to implant-based ones.
  • * Key factors linked to increased reconstruction loss included tumor size greater than 2 cm and multifocal recurrence; older age (50+) at the time of recurrence was also significant for complete loss of reconstruction. Regular follow-up imaging is suggested for early detection of recurrence.
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Background: Minimal change disease (MCD) is a common cause of the nephrotic syndrome. Several studies have shown an increased incidence of cancer in patients with MCD. However, there are no reports on the association between MCD and gastrointestinal stromal tumor (GIST).

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Background And Purpose: The European Society for Radiotherapy and Oncology (ESTRO) recently defined delineation guidelines for the clinical target volume for postmastectomy radiation therapy (PMRT) after immediate implant-based reconstruction for early-stage breast cancer. We analyzed the three-dimensional location and pattern of local recurrence in accordance with the reconstruction type and ESTRO-target volume.

Materials And Methods: This retrospective study involved patients who had undergone mastectomy with implant reconstruction between 2010 and 2019 and who had local recurrence as the first event.

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The pathogenesis of temporal lobe epilepsy (TLE) was originally considered to be acquired. However, some reports showed that TLE was clustered in some families, indicating a genetic etiology. With the popularity of genetic testing technology, eleven different types of familial TLE (FTLE), including ETL1-ETL11, have been reported, of which ETL9-ETL11 had not yet been included in the OMIM database.

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Central sensitization is essential in maintaining chronic pain induced by chronic pancreatitis (CP), but cortical modulation of painful CP remains elusive. Here, we examined the role of the anterior cingulate cortex (ACC) in the pathogenesis of abdominal hyperalgesia in a rat model of CP induced by intraductal administration of trinitrobenzene sulfonic acid (TNBS). TNBS treatment resulted in long-term abdominal hyperalgesia and anxiety in rats.

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